Successful Treatment Using Simeprevir, Sofosbuvir and Rituximab of a Severe Form of Hepatitis C Virus-related Mixed Cryoglobulinemia with Cardiac Involvement
Numerous extrahepatic manifestations have been reported in hepatitis C virus (HCV) infection, particularly mixed cryoglobulinemia (MC). MC generally responds to clearance of HCV under pegylated-interferon plus ribavirin treatment. New direct-acting antiviral agents have been licensed for HCV under d...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SMC MEDIA SRL
2015-11-01
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| Series: | European Journal of Case Reports in Internal Medicine |
| Subjects: | |
| Online Access: | http://ejcrim.com/index.php/EJCRIM/article/view/299 |
| _version_ | 1811240749453279232 |
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| author | Rafael Mahieu Christian Lavigne Geoffrey Urbanski Isabelle Fouchard Hubert Alexandra Ducancelle Françoise Lunel-Fabiani |
| author_facet | Rafael Mahieu Christian Lavigne Geoffrey Urbanski Isabelle Fouchard Hubert Alexandra Ducancelle Françoise Lunel-Fabiani |
| author_sort | Rafael Mahieu |
| collection | DOAJ |
| description | Numerous extrahepatic manifestations have been reported in hepatitis C virus (HCV) infection, particularly mixed cryoglobulinemia (MC). MC generally responds to clearance of HCV under pegylated-interferon plus ribavirin treatment. New direct-acting antiviral agents have been licensed for HCV under different combinations but have not been studied in severe forms of MC. Here, we present a case report describing a life-threatening form of MC with multivisceral involvement, which was successfully treated with concomitant rituximab, sofosbuvir and simeprevir. In light of the rapid clinical remission associated with sustained virological response and the excellent side-effect profile, this treatment should be considered as a first-line therapy in severe forms of MC. |
| first_indexed | 2024-04-12T13:25:46Z |
| format | Article |
| id | doaj.art-0d259d5a9e734356bae2d96e18bd699f |
| institution | Directory Open Access Journal |
| issn | 2284-2594 |
| language | English |
| last_indexed | 2024-04-12T13:25:46Z |
| publishDate | 2015-11-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj.art-0d259d5a9e734356bae2d96e18bd699f2022-12-22T03:31:19ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942015-11-012710.12890/2015_000299126Successful Treatment Using Simeprevir, Sofosbuvir and Rituximab of a Severe Form of Hepatitis C Virus-related Mixed Cryoglobulinemia with Cardiac InvolvementRafael Mahieu0Christian Lavigne1Geoffrey Urbanski2Isabelle Fouchard Hubert3Alexandra Ducancelle4Françoise Lunel-Fabiani5Department of Infectious Diseases, Angers University HospitalDepartment of Internal Medicine, Angers University HospitalDepartment of Internal Medicine, Angers University HospitalDepartment of Hepatology, Angers University HospitalDepartment of Biology of Infectious agents, Angers University Hospital; Laboratory HIFIH UPRES EA 3859 Medical University of AngersDepartment of Biology of Infectious agents, Angers University Hospital; Laboratory HIFIH UPRES EA 3859 Medical University of AngersNumerous extrahepatic manifestations have been reported in hepatitis C virus (HCV) infection, particularly mixed cryoglobulinemia (MC). MC generally responds to clearance of HCV under pegylated-interferon plus ribavirin treatment. New direct-acting antiviral agents have been licensed for HCV under different combinations but have not been studied in severe forms of MC. Here, we present a case report describing a life-threatening form of MC with multivisceral involvement, which was successfully treated with concomitant rituximab, sofosbuvir and simeprevir. In light of the rapid clinical remission associated with sustained virological response and the excellent side-effect profile, this treatment should be considered as a first-line therapy in severe forms of MC.http://ejcrim.com/index.php/EJCRIM/article/view/299Mixed cryoglobulinemiahepatitis C virussofosbuvirsimeprevir |
| spellingShingle | Rafael Mahieu Christian Lavigne Geoffrey Urbanski Isabelle Fouchard Hubert Alexandra Ducancelle Françoise Lunel-Fabiani Successful Treatment Using Simeprevir, Sofosbuvir and Rituximab of a Severe Form of Hepatitis C Virus-related Mixed Cryoglobulinemia with Cardiac Involvement European Journal of Case Reports in Internal Medicine Mixed cryoglobulinemia hepatitis C virus sofosbuvir simeprevir |
| title | Successful Treatment Using Simeprevir, Sofosbuvir and Rituximab of a Severe Form of Hepatitis C Virus-related Mixed Cryoglobulinemia with Cardiac Involvement |
| title_full | Successful Treatment Using Simeprevir, Sofosbuvir and Rituximab of a Severe Form of Hepatitis C Virus-related Mixed Cryoglobulinemia with Cardiac Involvement |
| title_fullStr | Successful Treatment Using Simeprevir, Sofosbuvir and Rituximab of a Severe Form of Hepatitis C Virus-related Mixed Cryoglobulinemia with Cardiac Involvement |
| title_full_unstemmed | Successful Treatment Using Simeprevir, Sofosbuvir and Rituximab of a Severe Form of Hepatitis C Virus-related Mixed Cryoglobulinemia with Cardiac Involvement |
| title_short | Successful Treatment Using Simeprevir, Sofosbuvir and Rituximab of a Severe Form of Hepatitis C Virus-related Mixed Cryoglobulinemia with Cardiac Involvement |
| title_sort | successful treatment using simeprevir sofosbuvir and rituximab of a severe form of hepatitis c virus related mixed cryoglobulinemia with cardiac involvement |
| topic | Mixed cryoglobulinemia hepatitis C virus sofosbuvir simeprevir |
| url | http://ejcrim.com/index.php/EJCRIM/article/view/299 |
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