Extracellular Vesicles from Adipose Tissue Stem Cells in Diabetes and Associated Cardiovascular Disease; Pathobiological Impact and Therapeutic Potential
Adipose tissue-derived stem cells (ADSCs) are pluripotent mesenchymal stem cells found in relatively high percentages in the adipose tissue and able to self-renew and differentiate into many different types of cells. “Extracellular vesicles (EVs), small membrane vesicular structures released during...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/24/9598 |
| _version_ | 1797544452034658304 |
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| author | Alina Constantin Alexandru Filippi Nicoleta Alexandru Miruna Nemecz Adriana Georgescu |
| author_facet | Alina Constantin Alexandru Filippi Nicoleta Alexandru Miruna Nemecz Adriana Georgescu |
| author_sort | Alina Constantin |
| collection | DOAJ |
| description | Adipose tissue-derived stem cells (ADSCs) are pluripotent mesenchymal stem cells found in relatively high percentages in the adipose tissue and able to self-renew and differentiate into many different types of cells. “Extracellular vesicles (EVs), small membrane vesicular structures released during cell activation, senescence, or apoptosis, act as mediators for long distance communication between cells, transferring their specific bioactive molecules into host target cells”. There is a general consensus on how to define and isolate ADSCs, however, multiple separation and characterization protocols are being used in the present which complicate the results’ integration in a single theory on ADSCs’ and their derived factors’ way of action. Metabolic syndrome and type 2 diabetes mellitus (T2DM) are mainly caused by abnormal adipose tissue size, distribution and metabolism and so ADSCs and their secretory factors such as EVs are currently investigated as therapeutics in these diseases. Moreover, due to their relatively easy isolation and propagation in culture and their differentiation ability, ADSCs are being employed in preclinical studies of implantable devices or prosthetics. This review aims to provide a comprehensive summary of the current knowledge on EVs secreted from ADSCs both as diagnostic biomarkers and therapeutics in diabetes and associated cardiovascular disease, the molecular mechanisms involved, as well as on the use of ADSC differentiation potential in cardiovascular tissue repair and prostheses. |
| first_indexed | 2024-03-10T14:00:42Z |
| format | Article |
| id | doaj.art-0d2705041e0c46d595d244ca2d8752c1 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T14:00:42Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0d2705041e0c46d595d244ca2d8752c12023-11-21T01:08:39ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-12-012124959810.3390/ijms21249598Extracellular Vesicles from Adipose Tissue Stem Cells in Diabetes and Associated Cardiovascular Disease; Pathobiological Impact and Therapeutic PotentialAlina Constantin0Alexandru Filippi1Nicoleta Alexandru2Miruna Nemecz3Adriana Georgescu4Institute of Cellular Biology and Pathology “Nicolae Simionescu” of Romanian Academy, 050568 Bucharest, RomaniaInstitute of Cellular Biology and Pathology “Nicolae Simionescu” of Romanian Academy, 050568 Bucharest, RomaniaInstitute of Cellular Biology and Pathology “Nicolae Simionescu” of Romanian Academy, 050568 Bucharest, RomaniaInstitute of Cellular Biology and Pathology “Nicolae Simionescu” of Romanian Academy, 050568 Bucharest, RomaniaInstitute of Cellular Biology and Pathology “Nicolae Simionescu” of Romanian Academy, 050568 Bucharest, RomaniaAdipose tissue-derived stem cells (ADSCs) are pluripotent mesenchymal stem cells found in relatively high percentages in the adipose tissue and able to self-renew and differentiate into many different types of cells. “Extracellular vesicles (EVs), small membrane vesicular structures released during cell activation, senescence, or apoptosis, act as mediators for long distance communication between cells, transferring their specific bioactive molecules into host target cells”. There is a general consensus on how to define and isolate ADSCs, however, multiple separation and characterization protocols are being used in the present which complicate the results’ integration in a single theory on ADSCs’ and their derived factors’ way of action. Metabolic syndrome and type 2 diabetes mellitus (T2DM) are mainly caused by abnormal adipose tissue size, distribution and metabolism and so ADSCs and their secretory factors such as EVs are currently investigated as therapeutics in these diseases. Moreover, due to their relatively easy isolation and propagation in culture and their differentiation ability, ADSCs are being employed in preclinical studies of implantable devices or prosthetics. This review aims to provide a comprehensive summary of the current knowledge on EVs secreted from ADSCs both as diagnostic biomarkers and therapeutics in diabetes and associated cardiovascular disease, the molecular mechanisms involved, as well as on the use of ADSC differentiation potential in cardiovascular tissue repair and prostheses.https://www.mdpi.com/1422-0067/21/24/9598adipose tissue-derived stem cellsextracellular vesiclesdiabetescardiovascular disease |
| spellingShingle | Alina Constantin Alexandru Filippi Nicoleta Alexandru Miruna Nemecz Adriana Georgescu Extracellular Vesicles from Adipose Tissue Stem Cells in Diabetes and Associated Cardiovascular Disease; Pathobiological Impact and Therapeutic Potential International Journal of Molecular Sciences adipose tissue-derived stem cells extracellular vesicles diabetes cardiovascular disease |
| title | Extracellular Vesicles from Adipose Tissue Stem Cells in Diabetes and Associated Cardiovascular Disease; Pathobiological Impact and Therapeutic Potential |
| title_full | Extracellular Vesicles from Adipose Tissue Stem Cells in Diabetes and Associated Cardiovascular Disease; Pathobiological Impact and Therapeutic Potential |
| title_fullStr | Extracellular Vesicles from Adipose Tissue Stem Cells in Diabetes and Associated Cardiovascular Disease; Pathobiological Impact and Therapeutic Potential |
| title_full_unstemmed | Extracellular Vesicles from Adipose Tissue Stem Cells in Diabetes and Associated Cardiovascular Disease; Pathobiological Impact and Therapeutic Potential |
| title_short | Extracellular Vesicles from Adipose Tissue Stem Cells in Diabetes and Associated Cardiovascular Disease; Pathobiological Impact and Therapeutic Potential |
| title_sort | extracellular vesicles from adipose tissue stem cells in diabetes and associated cardiovascular disease pathobiological impact and therapeutic potential |
| topic | adipose tissue-derived stem cells extracellular vesicles diabetes cardiovascular disease |
| url | https://www.mdpi.com/1422-0067/21/24/9598 |
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