The Expression of Prolactin Receptors in Benign Breast Tumors Is Not Associated with Serum Prolactin Level
The role of prolactin (PRL) and its receptors in the initiation and development of benign breast tumors (BBT) has not been sufficiently studied. An imbalance in the system of hormone homeostasis is crucial in the development of BBT. In particular, an association between elevated prolactin levels and...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/24/5866 |
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| author | Olena Kolomiiets Oleksandr Yazykov Artem Piddubnyi Mykola Lyndin Ivan Lukavenko Volodymyr Andryushchenko Anatolii Romaniuk Roman Moskalenko |
| author_facet | Olena Kolomiiets Oleksandr Yazykov Artem Piddubnyi Mykola Lyndin Ivan Lukavenko Volodymyr Andryushchenko Anatolii Romaniuk Roman Moskalenko |
| author_sort | Olena Kolomiiets |
| collection | DOAJ |
| description | The role of prolactin (PRL) and its receptors in the initiation and development of benign breast tumors (BBT) has not been sufficiently studied. An imbalance in the system of hormone homeostasis is crucial in the development of BBT. In particular, an association between elevated prolactin levels and the development of BBT has been reported. Our study showed no significant differences between PRL receptor (PRL-R) expression in BBT tissue under normal and elevated serum PRL levels. There was also no significant correlation between age, PRL-R expression in BBT tissue, intact tissue, and PRL level in the serum. There was a strong significant correlation (<i>p</i> < 0.01; r = 0.92) between PRL-R expression in BBT samples and intact breast tissue, which did not depend on the serum PRL level. There was also no significant difference in the expression of the proliferative marker Ki-67 in BBT tissues from women with normal and elevated levels of serum PRL (<i>p</i> > 0.05). No signs of PRL and its receptors were detected in the BBT cystic fluid women with elevated serum PRL levels. In summary, our prospective study showed that the expression of PRL-R in the tissue of BBT and physiological breast tissue does not depend on the level of serum PRL. |
| first_indexed | 2024-03-10T03:50:24Z |
| format | Article |
| id | doaj.art-0d2869772ba44df9b11a66ad19e0d767 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T03:50:24Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-0d2869772ba44df9b11a66ad19e0d7672023-11-23T08:57:23ZengMDPI AGJournal of Clinical Medicine2077-03832021-12-011024586610.3390/jcm10245866The Expression of Prolactin Receptors in Benign Breast Tumors Is Not Associated with Serum Prolactin LevelOlena Kolomiiets0Oleksandr Yazykov1Artem Piddubnyi2Mykola Lyndin3Ivan Lukavenko4Volodymyr Andryushchenko5Anatolii Romaniuk6Roman Moskalenko7Department of Pathology, Sumy State University, 40022 Sumy, UkrainePrivate Clinic “MRIYA”, 40004 Sumy, UkraineDepartment of Pathology, Sumy State University, 40022 Sumy, UkraineDepartment of Pathology, Sumy State University, 40022 Sumy, UkrainePrivate Clinic “MRIYA”, 40004 Sumy, UkrainePrivate Clinic “MRIYA”, 40004 Sumy, UkraineDepartment of Pathology, Sumy State University, 40022 Sumy, UkraineDepartment of Pathology, Sumy State University, 40022 Sumy, UkraineThe role of prolactin (PRL) and its receptors in the initiation and development of benign breast tumors (BBT) has not been sufficiently studied. An imbalance in the system of hormone homeostasis is crucial in the development of BBT. In particular, an association between elevated prolactin levels and the development of BBT has been reported. Our study showed no significant differences between PRL receptor (PRL-R) expression in BBT tissue under normal and elevated serum PRL levels. There was also no significant correlation between age, PRL-R expression in BBT tissue, intact tissue, and PRL level in the serum. There was a strong significant correlation (<i>p</i> < 0.01; r = 0.92) between PRL-R expression in BBT samples and intact breast tissue, which did not depend on the serum PRL level. There was also no significant difference in the expression of the proliferative marker Ki-67 in BBT tissues from women with normal and elevated levels of serum PRL (<i>p</i> > 0.05). No signs of PRL and its receptors were detected in the BBT cystic fluid women with elevated serum PRL levels. In summary, our prospective study showed that the expression of PRL-R in the tissue of BBT and physiological breast tissue does not depend on the level of serum PRL.https://www.mdpi.com/2077-0383/10/24/5866prolactinprolactin receptorsbenign breast tumors |
| spellingShingle | Olena Kolomiiets Oleksandr Yazykov Artem Piddubnyi Mykola Lyndin Ivan Lukavenko Volodymyr Andryushchenko Anatolii Romaniuk Roman Moskalenko The Expression of Prolactin Receptors in Benign Breast Tumors Is Not Associated with Serum Prolactin Level Journal of Clinical Medicine prolactin prolactin receptors benign breast tumors |
| title | The Expression of Prolactin Receptors in Benign Breast Tumors Is Not Associated with Serum Prolactin Level |
| title_full | The Expression of Prolactin Receptors in Benign Breast Tumors Is Not Associated with Serum Prolactin Level |
| title_fullStr | The Expression of Prolactin Receptors in Benign Breast Tumors Is Not Associated with Serum Prolactin Level |
| title_full_unstemmed | The Expression of Prolactin Receptors in Benign Breast Tumors Is Not Associated with Serum Prolactin Level |
| title_short | The Expression of Prolactin Receptors in Benign Breast Tumors Is Not Associated with Serum Prolactin Level |
| title_sort | expression of prolactin receptors in benign breast tumors is not associated with serum prolactin level |
| topic | prolactin prolactin receptors benign breast tumors |
| url | https://www.mdpi.com/2077-0383/10/24/5866 |
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