Non-healing Scalp Ulcer Accompanying Chronic Arsenicosis: A Case Report
Arsenic, an environmental toxin, significantly contributes to the development of several health problems. Epidemiological studies done across the globe have reported that a prolonged arsenic exposure has been associated with characteristic skin lesions, neuropathy and an increased risk of skin, lu...
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JCDR Research and Publications Private Limited
2014-05-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/4377/7471_CE(Ra)_E(C)_F(H)_PF1(PAK)_PFA(P)_PF2(PP)_PF2(PN).pdf |
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| author | AGNIK PAL INDRANIL BANERJEE SUKANTA SEN SANTANU KUMAR TRIPATHI |
| author_facet | AGNIK PAL INDRANIL BANERJEE SUKANTA SEN SANTANU KUMAR TRIPATHI |
| author_sort | AGNIK PAL |
| collection | DOAJ |
| description | Arsenic, an environmental toxin, significantly contributes to the development of several health problems. Epidemiological studies done
across the globe have reported that a prolonged arsenic exposure has been associated with characteristic skin lesions, neuropathy and
an increased risk of skin, lung, liver (angiosarcoma), bladder, kidney and colon cancers. In present study, we are reporting a case of a 60-
year-old male, who presented with a large (5cm x 4cm) painless ulcer in fronto-parietal area of scalp, with occasional oozing of blood. X-ray
of skull (AP and lateral view) revealed granular well-outlined osteolytic lesions in right fronto-parietal skull vault, which raised a suspicion
of malignancy. An incisional biopsy was taken and histopathology revealed no evidence of malignancy. A benign, non-healing skin ulcer is
rarely seen in a setting of chronic arsenicosis. His skin examination showed characteristic fine freckles of spotted pigmentary changes i.e.
classic rain-drop pigmentations which were present all over the body, particularly on trunk, palms and soles. Arsenic levels seen in hair and
nail of the patient were 1.23 micrograms/gram and 3.26 micrograms/gram respectively, which were in accordance with WHO suggested
diagnostic criteria of chronic arsenicosis. |
| first_indexed | 2024-12-21T19:54:29Z |
| format | Article |
| id | doaj.art-0d28e51b25bd45169942ba6679620ba2 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-21T19:54:29Z |
| publishDate | 2014-05-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-0d28e51b25bd45169942ba6679620ba22022-12-21T18:52:08ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2014-05-0185YD01YD0210.7860/JCDR/2014/7471.4377Non-healing Scalp Ulcer Accompanying Chronic Arsenicosis: A Case ReportAGNIK PAL0INDRANIL BANERJEE1SUKANTA SEN2SANTANU KUMAR TRIPATHI3Post-Graduate Student, Department of Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata, West Bengal, India.Post-Doctoral Student, Department of Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata, West Bengal, India.Post-Doctoral Student, Department of Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata, West Bengal, India.Professor and Head, Department of Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata, West Bengal, India.Arsenic, an environmental toxin, significantly contributes to the development of several health problems. Epidemiological studies done across the globe have reported that a prolonged arsenic exposure has been associated with characteristic skin lesions, neuropathy and an increased risk of skin, lung, liver (angiosarcoma), bladder, kidney and colon cancers. In present study, we are reporting a case of a 60- year-old male, who presented with a large (5cm x 4cm) painless ulcer in fronto-parietal area of scalp, with occasional oozing of blood. X-ray of skull (AP and lateral view) revealed granular well-outlined osteolytic lesions in right fronto-parietal skull vault, which raised a suspicion of malignancy. An incisional biopsy was taken and histopathology revealed no evidence of malignancy. A benign, non-healing skin ulcer is rarely seen in a setting of chronic arsenicosis. His skin examination showed characteristic fine freckles of spotted pigmentary changes i.e. classic rain-drop pigmentations which were present all over the body, particularly on trunk, palms and soles. Arsenic levels seen in hair and nail of the patient were 1.23 micrograms/gram and 3.26 micrograms/gram respectively, which were in accordance with WHO suggested diagnostic criteria of chronic arsenicosis.https://jcdr.net/articles/PDF/4377/7471_CE(Ra)_E(C)_F(H)_PF1(PAK)_PFA(P)_PF2(PP)_PF2(PN).pdfrain-drop pigmentationarsenicosis |
| spellingShingle | AGNIK PAL INDRANIL BANERJEE SUKANTA SEN SANTANU KUMAR TRIPATHI Non-healing Scalp Ulcer Accompanying Chronic Arsenicosis: A Case Report Journal of Clinical and Diagnostic Research rain-drop pigmentation arsenicosis |
| title | Non-healing Scalp Ulcer Accompanying Chronic Arsenicosis: A Case Report |
| title_full | Non-healing Scalp Ulcer Accompanying Chronic Arsenicosis: A Case Report |
| title_fullStr | Non-healing Scalp Ulcer Accompanying Chronic Arsenicosis: A Case Report |
| title_full_unstemmed | Non-healing Scalp Ulcer Accompanying Chronic Arsenicosis: A Case Report |
| title_short | Non-healing Scalp Ulcer Accompanying Chronic Arsenicosis: A Case Report |
| title_sort | non healing scalp ulcer accompanying chronic arsenicosis a case report |
| topic | rain-drop pigmentation arsenicosis |
| url | https://jcdr.net/articles/PDF/4377/7471_CE(Ra)_E(C)_F(H)_PF1(PAK)_PFA(P)_PF2(PP)_PF2(PN).pdf |
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