High Mortality of HLH in ICU Regardless Etiology or Treatment

High Mortality of HLH in ICU Regardless Etiology or Treatment

Background: Adult hemophagocytic lymphohistiocytosis (HLH) is highly lethal in the ICU. The diagnostic and therapeutic emergency that HLH represents is compounded by its unknown pathophysiological mechanisms. Here, we report on a large cohort of adult HLH in the ICU (ICU-HLH). We analyzed prognostic...

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Main Authors: Amandine Bichon, Jérémy Bourenne, Jérôme Allardet-Servent, Laurent Papazian, Sami Hraiech, Christophe Guervilly, Vanessa Pauly, Gilles Kaplanski, Djamel Mokart, Marc Gainnier, Julien Carvelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Medicine
Subjects:
hemophagocytic lymphohistiocytosis
macrophage activation syndrome
hemophagocytosis
cytokine storm
intensive care unit
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.735796/full

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