Novel Anterior Brainstem Magnetic Resonance Imaging Findings in Non-Small Cell Lung Cancer with Leptomeningeal Carcinomatosis
Leptomeningeal carcinomatosis (LC) is found in around 4% of patients with non-small cell lung cancer (NSCLC). The most common radiological finding of LC is diffuse leptomeningeal enhancement on contrast-enhanced brain magnetic resonance imaging (MRI). Herein, we report a novel brain MRI finding—non-...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fneur.2017.00579/full |
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| author | Chun-Yu Cheng Chun-Yu Cheng Chia-Yu Hsu Chia-Yu Hsu Yuan-Hsiung Tsai Yuan-Hsiung Tsai Kuang-Lin Lin Kuang-Lin Lin Cih-En Huang Cih-En Huang Yi-Hong Fan Yi-Hong Fan Shy-Chyi Chin Shy-Chyi Chin Yen-Chu Huang Yen-Chu Huang |
| author_facet | Chun-Yu Cheng Chun-Yu Cheng Chia-Yu Hsu Chia-Yu Hsu Yuan-Hsiung Tsai Yuan-Hsiung Tsai Kuang-Lin Lin Kuang-Lin Lin Cih-En Huang Cih-En Huang Yi-Hong Fan Yi-Hong Fan Shy-Chyi Chin Shy-Chyi Chin Yen-Chu Huang Yen-Chu Huang |
| author_sort | Chun-Yu Cheng |
| collection | DOAJ |
| description | Leptomeningeal carcinomatosis (LC) is found in around 4% of patients with non-small cell lung cancer (NSCLC). The most common radiological finding of LC is diffuse leptomeningeal enhancement on contrast-enhanced brain magnetic resonance imaging (MRI). Herein, we report a novel brain MRI finding—non-enhanced, band-like, symmetric restricted diffusion along the anterior surface of the brainstem—of LC in four patients with NSCLC. We also identified three additional cases with similar MRI findings in a literature review. We hypothesized that the restricted diffusion along the anterior brainstem was caused by malignant cells concentrating in the cistern around the brainstem and infiltrating into the circumferential perforating arteries along the anterior brainstem surface, which then resulted in microinfarctions. |
| first_indexed | 2024-12-22T04:35:25Z |
| format | Article |
| id | doaj.art-0d2959585ea24c32980f9198bcaf795f |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-22T04:35:25Z |
| publishDate | 2017-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-0d2959585ea24c32980f9198bcaf795f2022-12-21T18:38:54ZengFrontiers Media S.A.Frontiers in Neurology1664-22952017-10-01810.3389/fneur.2017.00579285776Novel Anterior Brainstem Magnetic Resonance Imaging Findings in Non-Small Cell Lung Cancer with Leptomeningeal CarcinomatosisChun-Yu Cheng0Chun-Yu Cheng1Chia-Yu Hsu2Chia-Yu Hsu3Yuan-Hsiung Tsai4Yuan-Hsiung Tsai5Kuang-Lin Lin6Kuang-Lin Lin7Cih-En Huang8Cih-En Huang9Yi-Hong Fan10Yi-Hong Fan11Shy-Chyi Chin12Shy-Chyi Chin13Yen-Chu Huang14Yen-Chu Huang15Department of Neurosurgery, Chang Gung Memorial Hospital, Chiayi, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Neurology, Chang Gung Memorial Hospital, Chiayi, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Pediatric Neurology, Chang Gung Children’s Hospital, Taoyuan, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanDivision of Hematology and Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanDivision of Chest, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Diagnostic Radiology, Chang Gung Memorial Hospital, Taoyuan, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Neurology, Chang Gung Memorial Hospital, Chiayi, TaiwanLeptomeningeal carcinomatosis (LC) is found in around 4% of patients with non-small cell lung cancer (NSCLC). The most common radiological finding of LC is diffuse leptomeningeal enhancement on contrast-enhanced brain magnetic resonance imaging (MRI). Herein, we report a novel brain MRI finding—non-enhanced, band-like, symmetric restricted diffusion along the anterior surface of the brainstem—of LC in four patients with NSCLC. We also identified three additional cases with similar MRI findings in a literature review. We hypothesized that the restricted diffusion along the anterior brainstem was caused by malignant cells concentrating in the cistern around the brainstem and infiltrating into the circumferential perforating arteries along the anterior brainstem surface, which then resulted in microinfarctions.http://journal.frontiersin.org/article/10.3389/fneur.2017.00579/fullbrainstemrestrictive diffusionbrain magnetic resonance imagingleptomeningeal carcinomatosislung cancer |
| spellingShingle | Chun-Yu Cheng Chun-Yu Cheng Chia-Yu Hsu Chia-Yu Hsu Yuan-Hsiung Tsai Yuan-Hsiung Tsai Kuang-Lin Lin Kuang-Lin Lin Cih-En Huang Cih-En Huang Yi-Hong Fan Yi-Hong Fan Shy-Chyi Chin Shy-Chyi Chin Yen-Chu Huang Yen-Chu Huang Novel Anterior Brainstem Magnetic Resonance Imaging Findings in Non-Small Cell Lung Cancer with Leptomeningeal Carcinomatosis Frontiers in Neurology brainstem restrictive diffusion brain magnetic resonance imaging leptomeningeal carcinomatosis lung cancer |
| title | Novel Anterior Brainstem Magnetic Resonance Imaging Findings in Non-Small Cell Lung Cancer with Leptomeningeal Carcinomatosis |
| title_full | Novel Anterior Brainstem Magnetic Resonance Imaging Findings in Non-Small Cell Lung Cancer with Leptomeningeal Carcinomatosis |
| title_fullStr | Novel Anterior Brainstem Magnetic Resonance Imaging Findings in Non-Small Cell Lung Cancer with Leptomeningeal Carcinomatosis |
| title_full_unstemmed | Novel Anterior Brainstem Magnetic Resonance Imaging Findings in Non-Small Cell Lung Cancer with Leptomeningeal Carcinomatosis |
| title_short | Novel Anterior Brainstem Magnetic Resonance Imaging Findings in Non-Small Cell Lung Cancer with Leptomeningeal Carcinomatosis |
| title_sort | novel anterior brainstem magnetic resonance imaging findings in non small cell lung cancer with leptomeningeal carcinomatosis |
| topic | brainstem restrictive diffusion brain magnetic resonance imaging leptomeningeal carcinomatosis lung cancer |
| url | http://journal.frontiersin.org/article/10.3389/fneur.2017.00579/full |
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