Influence of marital status on overall survival in patients with ovarian serous carcinoma: finding from the surveillance epidemiology and end results (SEER) database
Abstract Objective This study is to investigate the relationship between marital status and prognosis of patients with ovarian serous carcinoma. Results We performed data analysis from 19,276 patients identified from the SEER database of the National Cancer Center of the United States. 57.8% of the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-12-01
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| Series: | Journal of Ovarian Research |
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| Online Access: | https://doi.org/10.1186/s13048-019-0600-7 |
| _version_ | 1797972633700007936 |
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| author | Pei Luo Jian-Guo Zhou Su-Han Jin Ming-Song Qing Hu Ma |
| author_facet | Pei Luo Jian-Guo Zhou Su-Han Jin Ming-Song Qing Hu Ma |
| author_sort | Pei Luo |
| collection | DOAJ |
| description | Abstract Objective This study is to investigate the relationship between marital status and prognosis of patients with ovarian serous carcinoma. Results We performed data analysis from 19,276 patients identified from the SEER database of the National Cancer Center of the United States. 57.8% of the patients were married, 13.0% unmarried, and 29.2% separated/ divorced/widowed (SDW). The median overall survival time ofthe unmarried group and the married group are 48 months and 52 months respectively. Univariate Cox regression analysis showed that the patients with serous ovarian cancer in the unmarried group resulted in a hazard ratio (HR) of 1.14 (95% CI: 1.08–1.19%; P < 0.001), comparing to SDW group with a HR of 1.02 (95% CI: 0.98–1.19%; P = 0.26). However, the SDW group was not statistically significantly different from the married group. (median 32 vs 52 months). Multivariate Cox regression analysis presented the unmarried group leading to a HR of 1.05 (95% CI: 1.00–1.11%; P = 0.05), and the SDW group was not significant with a HR of 0.99 (95% CI: 0.95–1.03%; P = 0.57). Conclusion Unmarried patients with ovarian serous carcinoma have higherHRof overall survival. After controlling age, race, grade, radiation and year of diagnosis, unmarried patients were found to have a significantly higher risk of OS. Consequently, these patients are suggested to obtain more focused healthcare for the management of ovarian serous carcinoma. |
| first_indexed | 2024-04-11T03:51:35Z |
| format | Article |
| id | doaj.art-0d2aeeca6c624398996c5cf664f130fa |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-11T03:51:35Z |
| publishDate | 2019-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-0d2aeeca6c624398996c5cf664f130fa2023-01-02T01:49:34ZengBMCJournal of Ovarian Research1757-22152019-12-011211810.1186/s13048-019-0600-7Influence of marital status on overall survival in patients with ovarian serous carcinoma: finding from the surveillance epidemiology and end results (SEER) databasePei Luo0Jian-Guo Zhou1Su-Han Jin2Ming-Song Qing3Hu Ma4Department of Oncology, The Second Affiliated Hospital of Zunyi Medical UniversityDepartment of Oncology, The Second Affiliated Hospital of Zunyi Medical UniversityDepartment of Orthodontics, Affiliated Stomatology Hospital of Zunyi Medical UniversityDepartment of Orthopedics, Affiliated Hospital of Zunyi Medical UniversityDepartment of Oncology, The Second Affiliated Hospital of Zunyi Medical UniversityAbstract Objective This study is to investigate the relationship between marital status and prognosis of patients with ovarian serous carcinoma. Results We performed data analysis from 19,276 patients identified from the SEER database of the National Cancer Center of the United States. 57.8% of the patients were married, 13.0% unmarried, and 29.2% separated/ divorced/widowed (SDW). The median overall survival time ofthe unmarried group and the married group are 48 months and 52 months respectively. Univariate Cox regression analysis showed that the patients with serous ovarian cancer in the unmarried group resulted in a hazard ratio (HR) of 1.14 (95% CI: 1.08–1.19%; P < 0.001), comparing to SDW group with a HR of 1.02 (95% CI: 0.98–1.19%; P = 0.26). However, the SDW group was not statistically significantly different from the married group. (median 32 vs 52 months). Multivariate Cox regression analysis presented the unmarried group leading to a HR of 1.05 (95% CI: 1.00–1.11%; P = 0.05), and the SDW group was not significant with a HR of 0.99 (95% CI: 0.95–1.03%; P = 0.57). Conclusion Unmarried patients with ovarian serous carcinoma have higherHRof overall survival. After controlling age, race, grade, radiation and year of diagnosis, unmarried patients were found to have a significantly higher risk of OS. Consequently, these patients are suggested to obtain more focused healthcare for the management of ovarian serous carcinoma.https://doi.org/10.1186/s13048-019-0600-7Marital statusSEEROvarian serous carcinomaOverall survival |
| spellingShingle | Pei Luo Jian-Guo Zhou Su-Han Jin Ming-Song Qing Hu Ma Influence of marital status on overall survival in patients with ovarian serous carcinoma: finding from the surveillance epidemiology and end results (SEER) database Journal of Ovarian Research Marital status SEER Ovarian serous carcinoma Overall survival |
| title | Influence of marital status on overall survival in patients with ovarian serous carcinoma: finding from the surveillance epidemiology and end results (SEER) database |
| title_full | Influence of marital status on overall survival in patients with ovarian serous carcinoma: finding from the surveillance epidemiology and end results (SEER) database |
| title_fullStr | Influence of marital status on overall survival in patients with ovarian serous carcinoma: finding from the surveillance epidemiology and end results (SEER) database |
| title_full_unstemmed | Influence of marital status on overall survival in patients with ovarian serous carcinoma: finding from the surveillance epidemiology and end results (SEER) database |
| title_short | Influence of marital status on overall survival in patients with ovarian serous carcinoma: finding from the surveillance epidemiology and end results (SEER) database |
| title_sort | influence of marital status on overall survival in patients with ovarian serous carcinoma finding from the surveillance epidemiology and end results seer database |
| topic | Marital status SEER Ovarian serous carcinoma Overall survival |
| url | https://doi.org/10.1186/s13048-019-0600-7 |
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