Effects of immobilization and whole-body vibration on rat serum Type I collagen turnover
Objective: The aim of this study was to investigate the effects of short-term, high-magnitude whole-body vibration (WBV) on serum type I collagen turnover in immobilized rats. Materials and Methods: Thirty Wistar albino rats were randomly divided into the following 5 groups: immobilization (IS), imm...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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AVES
2016-08-01
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| Series: | Acta Orthopaedica et Traumatologica Turcica |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1017995X16300207 |
| _version_ | 1797908864693174272 |
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| author | Gürhan Dönmez Mahmut Nedim Doral Şenay Suljevic Mustafa Fevzi Sargon Hasan Bilgili Haydar Ali Demirel |
| author_facet | Gürhan Dönmez Mahmut Nedim Doral Şenay Suljevic Mustafa Fevzi Sargon Hasan Bilgili Haydar Ali Demirel |
| author_sort | Gürhan Dönmez |
| collection | DOAJ |
| description | Objective: The aim of this study was to investigate the effects of short-term, high-magnitude whole-body vibration (WBV) on serum type I collagen turnover in immobilized rats. Materials and Methods: Thirty Wistar albino rats were randomly divided into the following 5 groups: immobilization (IS), immobilization + remobilization (IR), immobilization + WBV (IV), control (C), and WBV control (CV). Immobilization was achieved by casting from the crista iliaca anterior superior to the lower part of the foot for 2 weeks. The applied WBV protocol involved a frequency of 45 Hz and amplitude of 3 mm for 7 days starting a day after the end of the immobilization period. Serum type I collagen turnover markers were measured by using ELISA kits. Results: Serum NH2-terminal propeptide of type I collagen (PINP) levels were significantly lower in the immobilization groups (p < 0.02) compared with the control groups. Although WBV improved PINP levels in the control groups, there were no differences in PINP levels among the immobilization groups. Similarly, serum COOH-terminal telopeptide of type I collagen (CTX) levels were higher in the WBV controls than their own controls (p < 0,05). Immobilization led to deterioration of tendon tissue, as observed by histopathological analysis with a transmission electron microscope. Conclusion: Although 1 week of WBV had a positive effect on type I collagen turnover in controls, it is not an efficient method for repairing tissue damage in the early stage following immobilization. Keywords: Rehabilitation, Immobilization, Whole-body vibration, Collagen, PINP |
| first_indexed | 2024-04-10T10:59:29Z |
| format | Article |
| id | doaj.art-0d2c9835c94c4c74af394c3e5e426f53 |
| institution | Directory Open Access Journal |
| issn | 1017-995X |
| language | English |
| last_indexed | 2024-04-10T10:59:29Z |
| publishDate | 2016-08-01 |
| publisher | AVES |
| record_format | Article |
| series | Acta Orthopaedica et Traumatologica Turcica |
| spelling | doaj.art-0d2c9835c94c4c74af394c3e5e426f532023-02-15T16:19:45ZengAVESActa Orthopaedica et Traumatologica Turcica1017-995X2016-08-01504452457Effects of immobilization and whole-body vibration on rat serum Type I collagen turnoverGürhan Dönmez0Mahmut Nedim Doral1Şenay Suljevic2Mustafa Fevzi Sargon3Hasan Bilgili4Haydar Ali Demirel5Hacettepe University, Dept. of Sports Medicine, Ankara, Turkey; Corresponding author. Hacettepe Üniversitesi, Erişkin Hastanesi Spor Hekimliği AD, Sıhhiye, 06100, Ankara, Turkey. Fax: +90 312 3051347.Hacettepe University, Dept. of Sports Medicine, Ankara, Turkey; Hacettepe University, Dept. of Orthopaedics and Traumatology, Ankara, TurkeyHacettepe University, Faculty of Sport Sciences, Ankara, TurkeyHacettepe University, Dept. of Anatomy, Ankara, TurkeyAnkara University, Dept. of Surgery Faculty of Veterinary Medicine, Ankara, TurkeyHacettepe University, Dept. of Sports Medicine, Ankara, Turkey; Hacettepe University, Faculty of Sport Sciences, Ankara, TurkeyObjective: The aim of this study was to investigate the effects of short-term, high-magnitude whole-body vibration (WBV) on serum type I collagen turnover in immobilized rats. Materials and Methods: Thirty Wistar albino rats were randomly divided into the following 5 groups: immobilization (IS), immobilization + remobilization (IR), immobilization + WBV (IV), control (C), and WBV control (CV). Immobilization was achieved by casting from the crista iliaca anterior superior to the lower part of the foot for 2 weeks. The applied WBV protocol involved a frequency of 45 Hz and amplitude of 3 mm for 7 days starting a day after the end of the immobilization period. Serum type I collagen turnover markers were measured by using ELISA kits. Results: Serum NH2-terminal propeptide of type I collagen (PINP) levels were significantly lower in the immobilization groups (p < 0.02) compared with the control groups. Although WBV improved PINP levels in the control groups, there were no differences in PINP levels among the immobilization groups. Similarly, serum COOH-terminal telopeptide of type I collagen (CTX) levels were higher in the WBV controls than their own controls (p < 0,05). Immobilization led to deterioration of tendon tissue, as observed by histopathological analysis with a transmission electron microscope. Conclusion: Although 1 week of WBV had a positive effect on type I collagen turnover in controls, it is not an efficient method for repairing tissue damage in the early stage following immobilization. Keywords: Rehabilitation, Immobilization, Whole-body vibration, Collagen, PINPhttp://www.sciencedirect.com/science/article/pii/S1017995X16300207 |
| spellingShingle | Gürhan Dönmez Mahmut Nedim Doral Şenay Suljevic Mustafa Fevzi Sargon Hasan Bilgili Haydar Ali Demirel Effects of immobilization and whole-body vibration on rat serum Type I collagen turnover Acta Orthopaedica et Traumatologica Turcica |
| title | Effects of immobilization and whole-body vibration on rat serum Type I collagen turnover |
| title_full | Effects of immobilization and whole-body vibration on rat serum Type I collagen turnover |
| title_fullStr | Effects of immobilization and whole-body vibration on rat serum Type I collagen turnover |
| title_full_unstemmed | Effects of immobilization and whole-body vibration on rat serum Type I collagen turnover |
| title_short | Effects of immobilization and whole-body vibration on rat serum Type I collagen turnover |
| title_sort | effects of immobilization and whole body vibration on rat serum type i collagen turnover |
| url | http://www.sciencedirect.com/science/article/pii/S1017995X16300207 |
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