Meta-Analysis on Associations of RGS1 and IL12A Polymorphisms with Celiac Disease Risk
The pathogenesis of celiac disease (CD) has been related to polymorphisms in the regulator of G-protein signaling 1 (RGS1) and interleukin-12 A (IL12A) genes, but the existing findings are inconsistent. Our aim is to investigate the associations of two single-nucleotide polymorphisms (SNPs) (rs28163...
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MDPI AG
2016-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/17/4/457 |
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| author | Cong-Cong Guo Man Wang Feng-Di Cao Wei-Huang Huang Di Xiao Xing-Guang Ye Mei-Ling Ou Na Zhang Bao-Huan Zhang Yang Liu Guang Yang Chun-Xia Jing |
| author_facet | Cong-Cong Guo Man Wang Feng-Di Cao Wei-Huang Huang Di Xiao Xing-Guang Ye Mei-Ling Ou Na Zhang Bao-Huan Zhang Yang Liu Guang Yang Chun-Xia Jing |
| author_sort | Cong-Cong Guo |
| collection | DOAJ |
| description | The pathogenesis of celiac disease (CD) has been related to polymorphisms in the regulator of G-protein signaling 1 (RGS1) and interleukin-12 A (IL12A) genes, but the existing findings are inconsistent. Our aim is to investigate the associations of two single-nucleotide polymorphisms (SNPs) (rs2816316 in RGS1 and rs17810546 in IL12A) with CD risk using meta-analysis. We searched PubMed and Web of Science on RGS1 rs2816316 and IL12A rs17810546 with CD risk. Odds ratio (OR) and 95% confidence interval (CI) of each SNP were estimated. All statistical analyses were performed on Stata 12.0. A total of seven studies were retrieved and analyzed. The available data indicated the minor allele C of rs2816316 was negatively associated with CD (C vs. A: OR = 0.77, 95% CI = 0.74–0.80), and a positive association was found for the minor allele G of rs17810546 (G vs. A: OR = 1.37, 95% CI = 1.31–1.43). The co-dominant model of genotype effect confirmed the significant associations between RGS1 rs2816316/IL12A rs17810546 and CD. No evidence of publication bias was observed. Our meta-analysis supports the associations of RGS1 and IL12A with CD and strongly calls for further studies to better understand the roles of RGS1 and IL12A in the pathogenesis of CD. |
| first_indexed | 2024-04-13T05:15:57Z |
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| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-13T05:15:57Z |
| publishDate | 2016-03-01 |
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| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0d2d05010e8a4a3f8db88773f4fae69b2022-12-22T03:00:54ZengMDPI AGInternational Journal of Molecular Sciences1422-00672016-03-0117445710.3390/ijms17040457ijms17040457Meta-Analysis on Associations of RGS1 and IL12A Polymorphisms with Celiac Disease RiskCong-Cong Guo0Man Wang1Feng-Di Cao2Wei-Huang Huang3Di Xiao4Xing-Guang Ye5Mei-Ling Ou6Na Zhang7Bao-Huan Zhang8Yang Liu9Guang Yang10Chun-Xia Jing11Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, ChinaDepartment of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, ChinaDepartment of Stomatology of the First Affiliated Hospital of Jinan University, Guangzhou 510632, ChinaDepartment of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, ChinaDepartment of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, ChinaDepartment of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, ChinaDepartment of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, ChinaDepartment of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, ChinaDepartment of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, ChinaDepartment of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, ChinaDepartment of Parasitology, School of Medicine, Jinan University, Guangzhou 510632, ChinaDepartment of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, ChinaThe pathogenesis of celiac disease (CD) has been related to polymorphisms in the regulator of G-protein signaling 1 (RGS1) and interleukin-12 A (IL12A) genes, but the existing findings are inconsistent. Our aim is to investigate the associations of two single-nucleotide polymorphisms (SNPs) (rs2816316 in RGS1 and rs17810546 in IL12A) with CD risk using meta-analysis. We searched PubMed and Web of Science on RGS1 rs2816316 and IL12A rs17810546 with CD risk. Odds ratio (OR) and 95% confidence interval (CI) of each SNP were estimated. All statistical analyses were performed on Stata 12.0. A total of seven studies were retrieved and analyzed. The available data indicated the minor allele C of rs2816316 was negatively associated with CD (C vs. A: OR = 0.77, 95% CI = 0.74–0.80), and a positive association was found for the minor allele G of rs17810546 (G vs. A: OR = 1.37, 95% CI = 1.31–1.43). The co-dominant model of genotype effect confirmed the significant associations between RGS1 rs2816316/IL12A rs17810546 and CD. No evidence of publication bias was observed. Our meta-analysis supports the associations of RGS1 and IL12A with CD and strongly calls for further studies to better understand the roles of RGS1 and IL12A in the pathogenesis of CD.http://www.mdpi.com/1422-0067/17/4/457celiac diseaseIL12Ameta-analysispolymorphismRGS1 |
| spellingShingle | Cong-Cong Guo Man Wang Feng-Di Cao Wei-Huang Huang Di Xiao Xing-Guang Ye Mei-Ling Ou Na Zhang Bao-Huan Zhang Yang Liu Guang Yang Chun-Xia Jing Meta-Analysis on Associations of RGS1 and IL12A Polymorphisms with Celiac Disease Risk International Journal of Molecular Sciences celiac disease IL12A meta-analysis polymorphism RGS1 |
| title | Meta-Analysis on Associations of RGS1 and IL12A Polymorphisms with Celiac Disease Risk |
| title_full | Meta-Analysis on Associations of RGS1 and IL12A Polymorphisms with Celiac Disease Risk |
| title_fullStr | Meta-Analysis on Associations of RGS1 and IL12A Polymorphisms with Celiac Disease Risk |
| title_full_unstemmed | Meta-Analysis on Associations of RGS1 and IL12A Polymorphisms with Celiac Disease Risk |
| title_short | Meta-Analysis on Associations of RGS1 and IL12A Polymorphisms with Celiac Disease Risk |
| title_sort | meta analysis on associations of rgs1 and il12a polymorphisms with celiac disease risk |
| topic | celiac disease IL12A meta-analysis polymorphism RGS1 |
| url | http://www.mdpi.com/1422-0067/17/4/457 |
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