MRNIP condensates promote DNA double-strand break sensing and end resection
The MRN complex is a critical sensor and processor of DNA double-strand breaks (DSBs). Here, the authors show that MRNIP forms liquid-like condensates to accelerate the MRN-mediated sensing and end resection of DSB, thereby promoting DSB repair.
Bibliographic Details
| Main Authors: |
Yun-Long Wang,
Wan-Wen Zhao,
Shao-Mei Bai,
Li-Li Feng,
Shu-Ying Bie,
Li Gong,
Fang Wang,
Ming-Biao Wei,
Wei-Xing Feng,
Xiao-Lin Pang,
Cao-Litao Qin,
Xin-Ke Yin,
Ying-Nai Wang,
Weihua Zhou,
Daniel R. Wahl,
Quentin Liu,
Ming Chen,
Mien-Chie Hung,
Xiang-Bo Wan |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-30303-w
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