The Underlying Role of the Glymphatic System and Meningeal Lymphatic Vessels in Cerebral Small Vessel Disease
There is a growing prevalence of vascular cognitive impairment (VCI) worldwide, and most research has suggested that cerebral small vessel disease (CSVD) is the main contributor to VCI. Several potential physiopathologic mechanisms have been proven to be involved in the process of CSVD, such as bloo...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/6/748 |
| _version_ | 1797489574240321536 |
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| author | Yu Tian Mengxi Zhao Yiyi Chen Mo Yang Yilong Wang |
| author_facet | Yu Tian Mengxi Zhao Yiyi Chen Mo Yang Yilong Wang |
| author_sort | Yu Tian |
| collection | DOAJ |
| description | There is a growing prevalence of vascular cognitive impairment (VCI) worldwide, and most research has suggested that cerebral small vessel disease (CSVD) is the main contributor to VCI. Several potential physiopathologic mechanisms have been proven to be involved in the process of CSVD, such as blood-brain barrier damage, small vessels stiffening, venous collagenosis, cerebral blood flow reduction, white matter rarefaction, chronic ischaemia, neuroinflammation, myelin damage, and subsequent neurodegeneration. However, there still is a limited overall understanding of the sequence and the relative importance of these mechanisms. The glymphatic system (GS) and meningeal lymphatic vessels (mLVs) are the analogs of the lymphatic system in the central nervous system (CNS). As such, these systems play critical roles in regulating cerebrospinal fluid (CSF) and interstitial fluid (ISF) transport, waste clearance, and, potentially, neuroinflammation. Accumulating evidence has suggested that the glymphatic and meningeal lymphatic vessels played vital roles in animal models of CSVD and patients with CSVD. Given the complexity of CSVD, it was significant to understand the underlying interaction between glymphatic and meningeal lymphatic transport with CSVD. Here, we provide a novel framework based on new advances in main four aspects, including vascular risk factors, potential mechanisms, clinical subtypes, and cognition, which aims to explain how the glymphatic system and meningeal lymphatic vessels contribute to the progression of CSVD and proposes a comprehensive insight into the novel therapeutic strategy of CSVD. |
| first_indexed | 2024-03-10T00:18:33Z |
| format | Article |
| id | doaj.art-0d2dfb723a874f28b1e4408df2723c8e |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T00:18:33Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-0d2dfb723a874f28b1e4408df2723c8e2023-11-23T15:46:14ZengMDPI AGBiomolecules2218-273X2022-05-0112674810.3390/biom12060748The Underlying Role of the Glymphatic System and Meningeal Lymphatic Vessels in Cerebral Small Vessel DiseaseYu Tian0Mengxi Zhao1Yiyi Chen2Mo Yang3Yilong Wang4Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, ChinaThere is a growing prevalence of vascular cognitive impairment (VCI) worldwide, and most research has suggested that cerebral small vessel disease (CSVD) is the main contributor to VCI. Several potential physiopathologic mechanisms have been proven to be involved in the process of CSVD, such as blood-brain barrier damage, small vessels stiffening, venous collagenosis, cerebral blood flow reduction, white matter rarefaction, chronic ischaemia, neuroinflammation, myelin damage, and subsequent neurodegeneration. However, there still is a limited overall understanding of the sequence and the relative importance of these mechanisms. The glymphatic system (GS) and meningeal lymphatic vessels (mLVs) are the analogs of the lymphatic system in the central nervous system (CNS). As such, these systems play critical roles in regulating cerebrospinal fluid (CSF) and interstitial fluid (ISF) transport, waste clearance, and, potentially, neuroinflammation. Accumulating evidence has suggested that the glymphatic and meningeal lymphatic vessels played vital roles in animal models of CSVD and patients with CSVD. Given the complexity of CSVD, it was significant to understand the underlying interaction between glymphatic and meningeal lymphatic transport with CSVD. Here, we provide a novel framework based on new advances in main four aspects, including vascular risk factors, potential mechanisms, clinical subtypes, and cognition, which aims to explain how the glymphatic system and meningeal lymphatic vessels contribute to the progression of CSVD and proposes a comprehensive insight into the novel therapeutic strategy of CSVD.https://www.mdpi.com/2218-273X/12/6/748cerebral small vessel diseaseglymphatic systemmeningeal lymphatic vesselcerebrospinal fluid |
| spellingShingle | Yu Tian Mengxi Zhao Yiyi Chen Mo Yang Yilong Wang The Underlying Role of the Glymphatic System and Meningeal Lymphatic Vessels in Cerebral Small Vessel Disease Biomolecules cerebral small vessel disease glymphatic system meningeal lymphatic vessel cerebrospinal fluid |
| title | The Underlying Role of the Glymphatic System and Meningeal Lymphatic Vessels in Cerebral Small Vessel Disease |
| title_full | The Underlying Role of the Glymphatic System and Meningeal Lymphatic Vessels in Cerebral Small Vessel Disease |
| title_fullStr | The Underlying Role of the Glymphatic System and Meningeal Lymphatic Vessels in Cerebral Small Vessel Disease |
| title_full_unstemmed | The Underlying Role of the Glymphatic System and Meningeal Lymphatic Vessels in Cerebral Small Vessel Disease |
| title_short | The Underlying Role of the Glymphatic System and Meningeal Lymphatic Vessels in Cerebral Small Vessel Disease |
| title_sort | underlying role of the glymphatic system and meningeal lymphatic vessels in cerebral small vessel disease |
| topic | cerebral small vessel disease glymphatic system meningeal lymphatic vessel cerebrospinal fluid |
| url | https://www.mdpi.com/2218-273X/12/6/748 |
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