Crosstalk between gut microbiota and renal ischemia/reperfusion injury
Renal ischemia-reperfusion injury (IRI) is the main cause of acute kidney injury and the cause of rapid renal dysfunction and high mortality. In recent years, with the gradual deepening of the understanding of the intestinal flora, exploring renal IRI from the perspective of the intestinal flora has...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.1015825/full |
| _version_ | 1798004546205646848 |
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| author | Peng Huang Jianwei Cao Jingyi Chen Yanrong Luo Xiaofang Gong Chengyi Wu Yu Wang |
| author_facet | Peng Huang Jianwei Cao Jingyi Chen Yanrong Luo Xiaofang Gong Chengyi Wu Yu Wang |
| author_sort | Peng Huang |
| collection | DOAJ |
| description | Renal ischemia-reperfusion injury (IRI) is the main cause of acute kidney injury and the cause of rapid renal dysfunction and high mortality. In recent years, with the gradual deepening of the understanding of the intestinal flora, exploring renal IRI from the perspective of the intestinal flora has become a research hotspot. It is well known that the intestinal flora plays an important role in maintaining human health, and dysbiosis is the change in the composition and function of the intestinal tract, which in turn causes intestinal barrier dysfunction. Studies have shown that there are significant differences in the composition of intestinal flora before and after renal IRI, and this difference is closely related to the occurrence and development of renal IRI and affects prognosis. In addition, toxins produced by dysregulated gut microbes enter the bloodstream, which in turn exacerbates kidney damage. This article reviews the research progress of intestinal flora and renal IRI, in order to provide new treatment ideas and strategies for renal IRI. |
| first_indexed | 2024-04-11T12:25:25Z |
| format | Article |
| id | doaj.art-0d3344028612473abda6fdbc47f08a8e |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-11T12:25:25Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-0d3344028612473abda6fdbc47f08a8e2022-12-22T04:23:57ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-09-011210.3389/fcimb.2022.10158251015825Crosstalk between gut microbiota and renal ischemia/reperfusion injuryPeng Huang0Jianwei Cao1Jingyi Chen2Yanrong Luo3Xiaofang Gong4Chengyi Wu5Yu Wang6Department of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, ChinaDepartment of Microscopic Orthopedics of Hand and Foot, Taihe Hospital, Hubei University of Medicine, Shiyan, ChinaDepartment of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, ChinaPhysical examination center, Shiyan Hospital of Integrated Traditional and Western Medicine, Shiyan, ChinaDepartment of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, ChinaDepartment of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, ChinaDepartment of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, ChinaRenal ischemia-reperfusion injury (IRI) is the main cause of acute kidney injury and the cause of rapid renal dysfunction and high mortality. In recent years, with the gradual deepening of the understanding of the intestinal flora, exploring renal IRI from the perspective of the intestinal flora has become a research hotspot. It is well known that the intestinal flora plays an important role in maintaining human health, and dysbiosis is the change in the composition and function of the intestinal tract, which in turn causes intestinal barrier dysfunction. Studies have shown that there are significant differences in the composition of intestinal flora before and after renal IRI, and this difference is closely related to the occurrence and development of renal IRI and affects prognosis. In addition, toxins produced by dysregulated gut microbes enter the bloodstream, which in turn exacerbates kidney damage. This article reviews the research progress of intestinal flora and renal IRI, in order to provide new treatment ideas and strategies for renal IRI.https://www.frontiersin.org/articles/10.3389/fcimb.2022.1015825/fullintestinal microbiotametabolitesrenal ischemia reperfusionintestinal dysbiosisbiomarkers |
| spellingShingle | Peng Huang Jianwei Cao Jingyi Chen Yanrong Luo Xiaofang Gong Chengyi Wu Yu Wang Crosstalk between gut microbiota and renal ischemia/reperfusion injury Frontiers in Cellular and Infection Microbiology intestinal microbiota metabolites renal ischemia reperfusion intestinal dysbiosis biomarkers |
| title | Crosstalk between gut microbiota and renal ischemia/reperfusion injury |
| title_full | Crosstalk between gut microbiota and renal ischemia/reperfusion injury |
| title_fullStr | Crosstalk between gut microbiota and renal ischemia/reperfusion injury |
| title_full_unstemmed | Crosstalk between gut microbiota and renal ischemia/reperfusion injury |
| title_short | Crosstalk between gut microbiota and renal ischemia/reperfusion injury |
| title_sort | crosstalk between gut microbiota and renal ischemia reperfusion injury |
| topic | intestinal microbiota metabolites renal ischemia reperfusion intestinal dysbiosis biomarkers |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.1015825/full |
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