CORRELATION BETWEEN BLOOD SERUM PSA LEVEL AND MMP-2 IN PROSTATE ADENOCARCINOMA
Objective: This study aims to prove the correlation between Prostate Specific Antigen (PSA) blood level and Matrix Metalloproteinase-2 (MMP-2) expression in patients with prostate adenocarcinoma. Material & method: Prostate cancer patients’ data from January 2009 to May 2012 were collected at th...
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| Format: | Article |
| Language: | English |
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IKATAN AHLI UROLOGI INDONESIA
2016-09-01
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| Series: | Jurnal Urologi Indonesia |
| Subjects: | |
| Online Access: | http://juri.urologi.or.id/juri/article/view/220 |
| _version_ | 1818948544565870592 |
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| author | Anny Setijo Rahaju Aniek Meidi Gondo Mastutik Sjahjenny Mustokoweni Arifa Mustika |
| author_facet | Anny Setijo Rahaju Aniek Meidi Gondo Mastutik Sjahjenny Mustokoweni Arifa Mustika |
| author_sort | Anny Setijo Rahaju |
| collection | DOAJ |
| description | Objective: This study aims to prove the correlation between Prostate Specific Antigen (PSA) blood level and Matrix Metalloproteinase-2 (MMP-2) expression in patients with prostate adenocarcinoma. Material & method: Prostate cancer patients’ data from January 2009 to May 2012 were collected at the Department of Pathology, Soetomo General Hospital Surabaya. Data collected included patient medical documents, PSA blood examination, and histopathological examination. Histopathology slides and paraffin blocks of needle biopsies, Transurethral Resection of Prostate (TURP) and radical prostatectomy of prostate cancer patients werere-read, then the samples that met the inclusion criteria were stained by immunohistochemistry using antibodies MMP-2. Results: Data collection was done to obtain data samples of prostate cancer patients in 2009 to 2012 comprising as many as 22 patients between the ages of 52-91 years. Prostate adenocarcinoma in age of 70-79 was found in 8 patients, with a mean age of 68 years. PSA values obtained from medical documents were between 8.6-594.41 ng/ml. Spearman's test performed in this study showed a positive correlation (one-tailed) (correlation coefficient (r) 0431, p < 0.05) between blood PSA level and MMP-2 expression in patients with prostate adenocarcinoma. Conclusion: Blood PSA level correlates positively with MMP-2 expression in prostate adenocarcinoma. |
| first_indexed | 2024-12-20T08:48:29Z |
| format | Article |
| id | doaj.art-0d33564df12b454881ca69750b1a8737 |
| institution | Directory Open Access Journal |
| issn | 0853-442X 2355-1402 |
| language | English |
| last_indexed | 2024-12-20T08:48:29Z |
| publishDate | 2016-09-01 |
| publisher | IKATAN AHLI UROLOGI INDONESIA |
| record_format | Article |
| series | Jurnal Urologi Indonesia |
| spelling | doaj.art-0d33564df12b454881ca69750b1a87372022-12-21T19:46:12ZengIKATAN AHLI UROLOGI INDONESIAJurnal Urologi Indonesia0853-442X2355-14022016-09-0123210.32421/juri.v23i2.220220CORRELATION BETWEEN BLOOD SERUM PSA LEVEL AND MMP-2 IN PROSTATE ADENOCARCINOMAAnny Setijo Rahaju0Aniek Meidi1Gondo Mastutik2Sjahjenny Mustokoweni3Arifa Mustika4Department of Anatomic Pathology, Faculty of Medicine/Universitas Airlangga, Soetomo General Hospital Surabaya.Department of Anatomic Pathology, Faculty of Medicine/Universitas Airlangga, Soetomo General Hospital Surabaya.Department of Anatomic Pathology, Faculty of Medicine/Universitas Airlangga, Soetomo General Hospital Surabaya.Department of Anatomic Pathology, Faculty of Medicine/Universitas Airlangga, Soetomo General Hospital Surabaya.Department of Pharmacology, Faculty of Medicine/Universitas Airlangga, Soetomo General Hospital Surabaya.Objective: This study aims to prove the correlation between Prostate Specific Antigen (PSA) blood level and Matrix Metalloproteinase-2 (MMP-2) expression in patients with prostate adenocarcinoma. Material & method: Prostate cancer patients’ data from January 2009 to May 2012 were collected at the Department of Pathology, Soetomo General Hospital Surabaya. Data collected included patient medical documents, PSA blood examination, and histopathological examination. Histopathology slides and paraffin blocks of needle biopsies, Transurethral Resection of Prostate (TURP) and radical prostatectomy of prostate cancer patients werere-read, then the samples that met the inclusion criteria were stained by immunohistochemistry using antibodies MMP-2. Results: Data collection was done to obtain data samples of prostate cancer patients in 2009 to 2012 comprising as many as 22 patients between the ages of 52-91 years. Prostate adenocarcinoma in age of 70-79 was found in 8 patients, with a mean age of 68 years. PSA values obtained from medical documents were between 8.6-594.41 ng/ml. Spearman's test performed in this study showed a positive correlation (one-tailed) (correlation coefficient (r) 0431, p < 0.05) between blood PSA level and MMP-2 expression in patients with prostate adenocarcinoma. Conclusion: Blood PSA level correlates positively with MMP-2 expression in prostate adenocarcinoma.http://juri.urologi.or.id/juri/article/view/220Prostate specific antigenmatrix metalloproteinase-2prostate adenocarcinoma |
| spellingShingle | Anny Setijo Rahaju Aniek Meidi Gondo Mastutik Sjahjenny Mustokoweni Arifa Mustika CORRELATION BETWEEN BLOOD SERUM PSA LEVEL AND MMP-2 IN PROSTATE ADENOCARCINOMA Jurnal Urologi Indonesia Prostate specific antigen matrix metalloproteinase-2 prostate adenocarcinoma |
| title | CORRELATION BETWEEN BLOOD SERUM PSA LEVEL AND MMP-2 IN PROSTATE ADENOCARCINOMA |
| title_full | CORRELATION BETWEEN BLOOD SERUM PSA LEVEL AND MMP-2 IN PROSTATE ADENOCARCINOMA |
| title_fullStr | CORRELATION BETWEEN BLOOD SERUM PSA LEVEL AND MMP-2 IN PROSTATE ADENOCARCINOMA |
| title_full_unstemmed | CORRELATION BETWEEN BLOOD SERUM PSA LEVEL AND MMP-2 IN PROSTATE ADENOCARCINOMA |
| title_short | CORRELATION BETWEEN BLOOD SERUM PSA LEVEL AND MMP-2 IN PROSTATE ADENOCARCINOMA |
| title_sort | correlation between blood serum psa level and mmp 2 in prostate adenocarcinoma |
| topic | Prostate specific antigen matrix metalloproteinase-2 prostate adenocarcinoma |
| url | http://juri.urologi.or.id/juri/article/view/220 |
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