Anti-Allergic Properties of Propolis: Evidence From Preclinical and Clinical Studies
Allergic diseases are a global health burden with increasing prevalence. Side effects of available medications (antihistamines and steroids), lack of patients’ perceived effectiveness and high cost of biologic therapies (omalizumab) are challenges to the clinical management of allergic diseases. As...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-01-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.785371/full |
| _version_ | 1818954348766429184 |
|---|---|
| author | Kong Yen Liew Nurain Irdayani Kamise Hui Ming Ong Poi Yi Aw Yong Fahmida Islam Ji Wei Tan Chau Ling Tham |
| author_facet | Kong Yen Liew Nurain Irdayani Kamise Hui Ming Ong Poi Yi Aw Yong Fahmida Islam Ji Wei Tan Chau Ling Tham |
| author_sort | Kong Yen Liew |
| collection | DOAJ |
| description | Allergic diseases are a global health burden with increasing prevalence. Side effects of available medications (antihistamines and steroids), lack of patients’ perceived effectiveness and high cost of biologic therapies (omalizumab) are challenges to the clinical management of allergic diseases. As allergy symptoms persist for a long time, complementary and alternative medicine (CAM) such as propolis may be considered a potential prophylactic or therapeutic option to avoid long-term medication use. Propolis is a natural resinous substance produced by bees. Although propolis is well known to possess antioxidant, antimicrobial, and anticancer properties, its anti-allergic potential is not fully explored. Several preclinical studies demonstrated the therapeutic effects of propolis extracts against allergic inflammation, asthma, allergic rhinitis, atopic dermatitis, and food allergy, which may be partly attributed to their inhibitory effects on the activation of mast cells and basophils. Clinically, the consumption of propolis as a supplement or an adjunct therapy is safe and attenuates various pathological conditions in asthma. Such an approach may be adopted for atopic dermatitis and allergic rhinitis. Although flavonoids (chrysin, kaempferol, galangin, and pinocembrin) and cinnamic acid derivatives (artepillin C and caffeic acid phenethyl ester) can contribute to the anti-allergic activities, they may not be present in all propolis samples due to variations in the chemical composition. Future studies should relate the anti-allergic activity of propolis with its chemical contents. This mini-review summarizes and discusses existing preclinical and clinical studies reporting the anti-allergic activities of propolis to provide insights into its potential applications in allergic diseases. |
| first_indexed | 2024-12-20T10:20:45Z |
| format | Article |
| id | doaj.art-0d35952912c64b77bbafc5dd445cddc6 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-20T10:20:45Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-0d35952912c64b77bbafc5dd445cddc62022-12-21T19:43:56ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-01-011210.3389/fphar.2021.785371785371Anti-Allergic Properties of Propolis: Evidence From Preclinical and Clinical StudiesKong Yen Liew0Nurain Irdayani Kamise1Hui Ming Ong2Poi Yi Aw Yong3Fahmida Islam4Ji Wei Tan5Chau Ling Tham6Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, MalaysiaDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, MalaysiaDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, MalaysiaSchool of Science, Monash University Malaysia, Subang Jaya, MalaysiaSchool of Science, Monash University Malaysia, Subang Jaya, MalaysiaSchool of Science, Monash University Malaysia, Subang Jaya, MalaysiaDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, MalaysiaAllergic diseases are a global health burden with increasing prevalence. Side effects of available medications (antihistamines and steroids), lack of patients’ perceived effectiveness and high cost of biologic therapies (omalizumab) are challenges to the clinical management of allergic diseases. As allergy symptoms persist for a long time, complementary and alternative medicine (CAM) such as propolis may be considered a potential prophylactic or therapeutic option to avoid long-term medication use. Propolis is a natural resinous substance produced by bees. Although propolis is well known to possess antioxidant, antimicrobial, and anticancer properties, its anti-allergic potential is not fully explored. Several preclinical studies demonstrated the therapeutic effects of propolis extracts against allergic inflammation, asthma, allergic rhinitis, atopic dermatitis, and food allergy, which may be partly attributed to their inhibitory effects on the activation of mast cells and basophils. Clinically, the consumption of propolis as a supplement or an adjunct therapy is safe and attenuates various pathological conditions in asthma. Such an approach may be adopted for atopic dermatitis and allergic rhinitis. Although flavonoids (chrysin, kaempferol, galangin, and pinocembrin) and cinnamic acid derivatives (artepillin C and caffeic acid phenethyl ester) can contribute to the anti-allergic activities, they may not be present in all propolis samples due to variations in the chemical composition. Future studies should relate the anti-allergic activity of propolis with its chemical contents. This mini-review summarizes and discusses existing preclinical and clinical studies reporting the anti-allergic activities of propolis to provide insights into its potential applications in allergic diseases.https://www.frontiersin.org/articles/10.3389/fphar.2021.785371/fullpropolisallergyasthmaallergic rhinitisatopic dermatitiseczema |
| spellingShingle | Kong Yen Liew Nurain Irdayani Kamise Hui Ming Ong Poi Yi Aw Yong Fahmida Islam Ji Wei Tan Chau Ling Tham Anti-Allergic Properties of Propolis: Evidence From Preclinical and Clinical Studies Frontiers in Pharmacology propolis allergy asthma allergic rhinitis atopic dermatitis eczema |
| title | Anti-Allergic Properties of Propolis: Evidence From Preclinical and Clinical Studies |
| title_full | Anti-Allergic Properties of Propolis: Evidence From Preclinical and Clinical Studies |
| title_fullStr | Anti-Allergic Properties of Propolis: Evidence From Preclinical and Clinical Studies |
| title_full_unstemmed | Anti-Allergic Properties of Propolis: Evidence From Preclinical and Clinical Studies |
| title_short | Anti-Allergic Properties of Propolis: Evidence From Preclinical and Clinical Studies |
| title_sort | anti allergic properties of propolis evidence from preclinical and clinical studies |
| topic | propolis allergy asthma allergic rhinitis atopic dermatitis eczema |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.785371/full |
| work_keys_str_mv | AT kongyenliew antiallergicpropertiesofpropolisevidencefrompreclinicalandclinicalstudies AT nurainirdayanikamise antiallergicpropertiesofpropolisevidencefrompreclinicalandclinicalstudies AT huimingong antiallergicpropertiesofpropolisevidencefrompreclinicalandclinicalstudies AT poiyiawyong antiallergicpropertiesofpropolisevidencefrompreclinicalandclinicalstudies AT fahmidaislam antiallergicpropertiesofpropolisevidencefrompreclinicalandclinicalstudies AT jiweitan antiallergicpropertiesofpropolisevidencefrompreclinicalandclinicalstudies AT chaulingtham antiallergicpropertiesofpropolisevidencefrompreclinicalandclinicalstudies |