Early Signs of Atherogenic Features in the HDL Lipidomes of Normolipidemic Patients Newly Diagnosed with Type 2 Diabetes
Cardiovascular disease (CVD) is the major cause of death in patients with type-2 diabetes mellitus (T2DM), although the factors that accelerate atherosclerosis in these patients are poorly understood. The identification of the altered quantity and quality of lipoproteins, closely related to atheroge...
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| Format: | Article |
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MDPI AG
2020-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/22/8835 |
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| author | Christina E. Kostara Eleuterio Ferrannini Eleni T. Bairaktari Athanasios Papathanasiou Moses Elisaf Vasilis Tsimihodimos |
| author_facet | Christina E. Kostara Eleuterio Ferrannini Eleni T. Bairaktari Athanasios Papathanasiou Moses Elisaf Vasilis Tsimihodimos |
| author_sort | Christina E. Kostara |
| collection | DOAJ |
| description | Cardiovascular disease (CVD) is the major cause of death in patients with type-2 diabetes mellitus (T2DM), although the factors that accelerate atherosclerosis in these patients are poorly understood. The identification of the altered quantity and quality of lipoproteins, closely related to atherogenesis, is limited in routine to a pattern of high triglycerides and low HDL-cholesterol (HDL-C) and in research as dysfunctional HDLs. We used the emerging NMR-based lipidomic technology to investigate compositional features of the HDLs of healthy individuals with normal coronary arteries, drug-naïve; recently diagnosed T2DM patients with normal coronary arteries; and patients with recent acute coronary syndrome. Patients with T2DM and normal serum lipid profiles even at diagnosis presented significant lipid alterations in HDL, characterized by higher triglycerides, lysophosphatidylcholine and saturated fatty acids; and lower cholesterol, phosphatidylcholine, phosphatidylethanolamine, sphingomyelin, plasmalogens and polyunsaturated fatty acids, an atherogenic pattern that may be involved in the pathogenesis of atherosclerosis. These changes are qualitatively similar to those found, more profoundly, in normolipidemic patients with established Coronary Heart Disease (CHD). We also conclude that NMR-based lipidomics offer a novel holistic exploratory approach for identifying and quantifying lipid species in biological matrixes in physiological processes and disease states or in disease biomarker discovery. |
| first_indexed | 2024-03-10T14:39:35Z |
| format | Article |
| id | doaj.art-0d360d04a3ef4b2089ad184922297737 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T14:39:35Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0d360d04a3ef4b2089ad1849222977372023-11-20T21:54:42ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-012122883510.3390/ijms21228835Early Signs of Atherogenic Features in the HDL Lipidomes of Normolipidemic Patients Newly Diagnosed with Type 2 DiabetesChristina E. Kostara0Eleuterio Ferrannini1Eleni T. Bairaktari2Athanasios Papathanasiou3Moses Elisaf4Vasilis Tsimihodimos5Laboratory of Clinical Chemistry, Faculty of Medicine, University of Ioannina, 45110 Ioannina, GreeceInstitute of Clinical Physiology, National Research Council, 56124 Pisa, ItalyLaboratory of Clinical Chemistry, Faculty of Medicine, University of Ioannina, 45110 Ioannina, GreeceDepartment of Internal Medicine, Faculty of Medicine, University of Ioannina, 45110 Ioannina, GreeceDepartment of Internal Medicine, Faculty of Medicine, University of Ioannina, 45110 Ioannina, GreeceDepartment of Internal Medicine, Faculty of Medicine, University of Ioannina, 45110 Ioannina, GreeceCardiovascular disease (CVD) is the major cause of death in patients with type-2 diabetes mellitus (T2DM), although the factors that accelerate atherosclerosis in these patients are poorly understood. The identification of the altered quantity and quality of lipoproteins, closely related to atherogenesis, is limited in routine to a pattern of high triglycerides and low HDL-cholesterol (HDL-C) and in research as dysfunctional HDLs. We used the emerging NMR-based lipidomic technology to investigate compositional features of the HDLs of healthy individuals with normal coronary arteries, drug-naïve; recently diagnosed T2DM patients with normal coronary arteries; and patients with recent acute coronary syndrome. Patients with T2DM and normal serum lipid profiles even at diagnosis presented significant lipid alterations in HDL, characterized by higher triglycerides, lysophosphatidylcholine and saturated fatty acids; and lower cholesterol, phosphatidylcholine, phosphatidylethanolamine, sphingomyelin, plasmalogens and polyunsaturated fatty acids, an atherogenic pattern that may be involved in the pathogenesis of atherosclerosis. These changes are qualitatively similar to those found, more profoundly, in normolipidemic patients with established Coronary Heart Disease (CHD). We also conclude that NMR-based lipidomics offer a novel holistic exploratory approach for identifying and quantifying lipid species in biological matrixes in physiological processes and disease states or in disease biomarker discovery.https://www.mdpi.com/1422-0067/21/22/8835HDLtype 2 diabetescoronary heart diseaselipidomics |
| spellingShingle | Christina E. Kostara Eleuterio Ferrannini Eleni T. Bairaktari Athanasios Papathanasiou Moses Elisaf Vasilis Tsimihodimos Early Signs of Atherogenic Features in the HDL Lipidomes of Normolipidemic Patients Newly Diagnosed with Type 2 Diabetes International Journal of Molecular Sciences HDL type 2 diabetes coronary heart disease lipidomics |
| title | Early Signs of Atherogenic Features in the HDL Lipidomes of Normolipidemic Patients Newly Diagnosed with Type 2 Diabetes |
| title_full | Early Signs of Atherogenic Features in the HDL Lipidomes of Normolipidemic Patients Newly Diagnosed with Type 2 Diabetes |
| title_fullStr | Early Signs of Atherogenic Features in the HDL Lipidomes of Normolipidemic Patients Newly Diagnosed with Type 2 Diabetes |
| title_full_unstemmed | Early Signs of Atherogenic Features in the HDL Lipidomes of Normolipidemic Patients Newly Diagnosed with Type 2 Diabetes |
| title_short | Early Signs of Atherogenic Features in the HDL Lipidomes of Normolipidemic Patients Newly Diagnosed with Type 2 Diabetes |
| title_sort | early signs of atherogenic features in the hdl lipidomes of normolipidemic patients newly diagnosed with type 2 diabetes |
| topic | HDL type 2 diabetes coronary heart disease lipidomics |
| url | https://www.mdpi.com/1422-0067/21/22/8835 |
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