Altered expression of microRNAs in the myocardium of rats with acute myocardial infarction
<p>Abstract</p> <p>Background</p> <p>MicroRNAs(miRNAs) are important cellular components and their dysfunction is associated with various diseases. Acute myocardial infarction (AMI) is one of the most serious cardiovascular diseases. Although several miRNAs are reported...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-03-01
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| Series: | BMC Cardiovascular Disorders |
| Online Access: | http://www.biomedcentral.com/1471-2261/10/11 |
| _version_ | 1818753908048134144 |
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| author | Guo Yanhong Shi Bing Wang Juan Gao Wei |
| author_facet | Guo Yanhong Shi Bing Wang Juan Gao Wei |
| author_sort | Guo Yanhong |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>MicroRNAs(miRNAs) are important cellular components and their dysfunction is associated with various diseases. Acute myocardial infarction (AMI) is one of the most serious cardiovascular diseases. Although several miRNAs are reported to be associated with AMI, more novel miRNAs are needed to further investigate and improve certainty</p> <p>Methods</p> <p>We applied a well-established acute myocardial infarction rat model and performed miRNAs microarray experiments upon the myocardium tissue of rats with AMI and under sham control. We identified the differentially expressed miRNAs and analyzed the function of miRNA targets, transcription factors, and host genes based on bioinformatics.</p> <p>Results</p> <p>As a result, the levels of expression of seventeen miRNAs significantly deregulated, of which four miRNAs were further validated by qRT-PCR. In addition, we observed that the transcription factors, targets, and host genes of these deregulated miRNAs are enriched in cardiovascular-related functions.</p> <p>Conclusion</p> <p>We found that the miRNAs expression level altered in rats with AMI and differentially expressed miRNAs may be novel biomarkers of AMI.</p> |
| first_indexed | 2024-12-18T05:14:49Z |
| format | Article |
| id | doaj.art-0d36ef405a9a4863930a4a1846670f0a |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-18T05:14:49Z |
| publishDate | 2010-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-0d36ef405a9a4863930a4a1846670f0a2022-12-21T21:19:48ZengBMCBMC Cardiovascular Disorders1471-22612010-03-011011110.1186/1471-2261-10-11Altered expression of microRNAs in the myocardium of rats with acute myocardial infarctionGuo YanhongShi BingWang JuanGao Wei<p>Abstract</p> <p>Background</p> <p>MicroRNAs(miRNAs) are important cellular components and their dysfunction is associated with various diseases. Acute myocardial infarction (AMI) is one of the most serious cardiovascular diseases. Although several miRNAs are reported to be associated with AMI, more novel miRNAs are needed to further investigate and improve certainty</p> <p>Methods</p> <p>We applied a well-established acute myocardial infarction rat model and performed miRNAs microarray experiments upon the myocardium tissue of rats with AMI and under sham control. We identified the differentially expressed miRNAs and analyzed the function of miRNA targets, transcription factors, and host genes based on bioinformatics.</p> <p>Results</p> <p>As a result, the levels of expression of seventeen miRNAs significantly deregulated, of which four miRNAs were further validated by qRT-PCR. In addition, we observed that the transcription factors, targets, and host genes of these deregulated miRNAs are enriched in cardiovascular-related functions.</p> <p>Conclusion</p> <p>We found that the miRNAs expression level altered in rats with AMI and differentially expressed miRNAs may be novel biomarkers of AMI.</p>http://www.biomedcentral.com/1471-2261/10/11 |
| spellingShingle | Guo Yanhong Shi Bing Wang Juan Gao Wei Altered expression of microRNAs in the myocardium of rats with acute myocardial infarction BMC Cardiovascular Disorders |
| title | Altered expression of microRNAs in the myocardium of rats with acute myocardial infarction |
| title_full | Altered expression of microRNAs in the myocardium of rats with acute myocardial infarction |
| title_fullStr | Altered expression of microRNAs in the myocardium of rats with acute myocardial infarction |
| title_full_unstemmed | Altered expression of microRNAs in the myocardium of rats with acute myocardial infarction |
| title_short | Altered expression of microRNAs in the myocardium of rats with acute myocardial infarction |
| title_sort | altered expression of micrornas in the myocardium of rats with acute myocardial infarction |
| url | http://www.biomedcentral.com/1471-2261/10/11 |
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