HAV infection in Brazilian men who have sex with men: The importance of surveillance to avoid outbreaks.
<h4>Background</h4>Hepatitis A is a fecal-oral infection caused by hepatitis A virus (HAV). Men who have sex with men (MSM) and transgender women (TW) have been reported as target groups for HAV infection. This study aimed to determine the seroprevalence, risk factors, and circulating st...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0256818 |
| _version_ | 1818460504216043520 |
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| author | Lisie Souza Castro Grazielli Rocha de Rezende Fernanda Rodas Pires Fernandes Larissa Melo Bandeira Gabriela Alves Cesar Barbara Vieira do Lago Michele Soares Gomes Gouvêa Ana R C Motta-Castro |
| author_facet | Lisie Souza Castro Grazielli Rocha de Rezende Fernanda Rodas Pires Fernandes Larissa Melo Bandeira Gabriela Alves Cesar Barbara Vieira do Lago Michele Soares Gomes Gouvêa Ana R C Motta-Castro |
| author_sort | Lisie Souza Castro |
| collection | DOAJ |
| description | <h4>Background</h4>Hepatitis A is a fecal-oral infection caused by hepatitis A virus (HAV). Men who have sex with men (MSM) and transgender women (TW) have been reported as target groups for HAV infection. This study aimed to determine the seroprevalence, risk factors, and circulating strains associated with HAV infection among MSM and TW in Central Brazil.<h4>Methods</h4>A cross-sectional study was conducted from November 2011 to September 2013. Serum samples were collected from 425 individuals for anti-HAV antibody testing and HAV molecular characterization. Of them, 149 (35.1%) participants were self-identified as transgender women. Statistical analysis was performed to evaluate the risk factors of HAV seropositivity.<h4>Results</h4>The seroprevalence of HAV exposure was 69.7% (95% Confidence Interval: 65.3-74.0%). Serological evidence of HAV was significantly higher in participants who self-identified as transgender women (83.2%) than MSM (62.3%). Increasing age, non-white race, and lower monthly household income were independently associated with HAV exposure among MSM. Only lower monthly household income was independently associated with HAV exposure among TW. One anti-HAV IgM positive sample, from a transgender woman (0.2%), was detected and classified as subgenotype IA.<h4>Conclusions</h4>High HAV prevalence was observed, markedly among TW. Considering the risky sexual behaviors this population is exposed to, HAV vaccination and prevention programs targeting this population should be considered to prevent outbreaks and the burden of the disease. |
| first_indexed | 2024-12-14T23:31:18Z |
| format | Article |
| id | doaj.art-0d39b1f485c947ae802561939af6610d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T23:31:18Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0d39b1f485c947ae802561939af6610d2022-12-21T22:43:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01169e025681810.1371/journal.pone.0256818HAV infection in Brazilian men who have sex with men: The importance of surveillance to avoid outbreaks.Lisie Souza CastroGrazielli Rocha de RezendeFernanda Rodas Pires FernandesLarissa Melo BandeiraGabriela Alves CesarBarbara Vieira do LagoMichele Soares Gomes GouvêaAna R C Motta-Castro<h4>Background</h4>Hepatitis A is a fecal-oral infection caused by hepatitis A virus (HAV). Men who have sex with men (MSM) and transgender women (TW) have been reported as target groups for HAV infection. This study aimed to determine the seroprevalence, risk factors, and circulating strains associated with HAV infection among MSM and TW in Central Brazil.<h4>Methods</h4>A cross-sectional study was conducted from November 2011 to September 2013. Serum samples were collected from 425 individuals for anti-HAV antibody testing and HAV molecular characterization. Of them, 149 (35.1%) participants were self-identified as transgender women. Statistical analysis was performed to evaluate the risk factors of HAV seropositivity.<h4>Results</h4>The seroprevalence of HAV exposure was 69.7% (95% Confidence Interval: 65.3-74.0%). Serological evidence of HAV was significantly higher in participants who self-identified as transgender women (83.2%) than MSM (62.3%). Increasing age, non-white race, and lower monthly household income were independently associated with HAV exposure among MSM. Only lower monthly household income was independently associated with HAV exposure among TW. One anti-HAV IgM positive sample, from a transgender woman (0.2%), was detected and classified as subgenotype IA.<h4>Conclusions</h4>High HAV prevalence was observed, markedly among TW. Considering the risky sexual behaviors this population is exposed to, HAV vaccination and prevention programs targeting this population should be considered to prevent outbreaks and the burden of the disease.https://doi.org/10.1371/journal.pone.0256818 |
| spellingShingle | Lisie Souza Castro Grazielli Rocha de Rezende Fernanda Rodas Pires Fernandes Larissa Melo Bandeira Gabriela Alves Cesar Barbara Vieira do Lago Michele Soares Gomes Gouvêa Ana R C Motta-Castro HAV infection in Brazilian men who have sex with men: The importance of surveillance to avoid outbreaks. PLoS ONE |
| title | HAV infection in Brazilian men who have sex with men: The importance of surveillance to avoid outbreaks. |
| title_full | HAV infection in Brazilian men who have sex with men: The importance of surveillance to avoid outbreaks. |
| title_fullStr | HAV infection in Brazilian men who have sex with men: The importance of surveillance to avoid outbreaks. |
| title_full_unstemmed | HAV infection in Brazilian men who have sex with men: The importance of surveillance to avoid outbreaks. |
| title_short | HAV infection in Brazilian men who have sex with men: The importance of surveillance to avoid outbreaks. |
| title_sort | hav infection in brazilian men who have sex with men the importance of surveillance to avoid outbreaks |
| url | https://doi.org/10.1371/journal.pone.0256818 |
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