Nanotechnology in Bladder Cancer: Diagnosis and Treatment
Bladder cancer (BC) is the second most common cancer of the urinary tract in men and the fourth most common cancer in women, and its incidence rises with age. There are many conventional methods for diagnosis and treatment of BC. There are some current biomarkers and clinical tests for the diagnosis...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/9/2214 |
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| author | Mahmood Barani Seyedeh Maryam Hosseinikhah Abbas Rahdar Leila Farhoudi Rabia Arshad Magali Cucchiarini Sadanand Pandey |
| author_facet | Mahmood Barani Seyedeh Maryam Hosseinikhah Abbas Rahdar Leila Farhoudi Rabia Arshad Magali Cucchiarini Sadanand Pandey |
| author_sort | Mahmood Barani |
| collection | DOAJ |
| description | Bladder cancer (BC) is the second most common cancer of the urinary tract in men and the fourth most common cancer in women, and its incidence rises with age. There are many conventional methods for diagnosis and treatment of BC. There are some current biomarkers and clinical tests for the diagnosis and treatment of BC. For example, radiotherapy combined with chemotherapy and surgical, but residual tumor cells mostly cause tumor recurrence. In addition, chemotherapy after transurethral resection causes high side effects, and lack of selectivity, and low sensitivity in sensing. Therefore, it is essential to improve new procedures for the diagnosis and treatment of BC. Nanotechnology has recently sparked an interest in a variety of areas, including medicine, chemistry, physics, and biology. Nanoparticles (NP) have been used in tumor therapies as appropriate tools for enhancing drug delivery efficacy and enabling therapeutic performance. It is noteworthy, nanomaterial could be reduced the limitation of conventional cancer diagnosis and treatments. Since, the major disadvantages of therapeutic drugs are their insolubility in an aqueous solvent, for instance, paclitaxel (PTX) is one of the important therapeutic agents utilized to treating BC, due to its ability to prevent cancer cell growth. However, its major problem is the poor solubility, which has confirmed to be a challenge when improving stable formulations for BC treatment. In order to reduce this challenge, anti-cancer drugs can be loaded into NPs that can improve water solubility. In our review, we state several nanosystem, which can effective and useful for the diagnosis, treatment of BC. We investigate the function of metal NPs, polymeric NPs, liposomes, and exosomes accompanied therapeutic agents for BC Therapy, and then focused on the potential of nanotechnology to improve conventional approaches in sensing. |
| first_indexed | 2024-03-10T11:41:04Z |
| format | Article |
| id | doaj.art-0d3c3d6fa35e42c7a23940b1f8c678ce |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T11:41:04Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-0d3c3d6fa35e42c7a23940b1f8c678ce2023-11-21T18:26:52ZengMDPI AGCancers2072-66942021-05-01139221410.3390/cancers13092214Nanotechnology in Bladder Cancer: Diagnosis and TreatmentMahmood Barani0Seyedeh Maryam Hosseinikhah1Abbas Rahdar2Leila Farhoudi3Rabia Arshad4Magali Cucchiarini5Sadanand Pandey6Department of Chemistry, Shahid Bahonar University of Kerman, Kerman 76169-14111, IranNanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 91886-17871, IranDepartment of Physics, Faculty of Science, University of Zabol, Zabol 98613-35856, IranNanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 91886-17871, IranDepartment of Pharmacy, Quaid-I-Azam University, Islamabad 45320, PakistanCenter of Experimental Orthopaedics, Saarland University Medical Center, 66421 Homburg/Saar, GermanyDepartment of Chemistry, College of Natural Science, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, KoreaBladder cancer (BC) is the second most common cancer of the urinary tract in men and the fourth most common cancer in women, and its incidence rises with age. There are many conventional methods for diagnosis and treatment of BC. There are some current biomarkers and clinical tests for the diagnosis and treatment of BC. For example, radiotherapy combined with chemotherapy and surgical, but residual tumor cells mostly cause tumor recurrence. In addition, chemotherapy after transurethral resection causes high side effects, and lack of selectivity, and low sensitivity in sensing. Therefore, it is essential to improve new procedures for the diagnosis and treatment of BC. Nanotechnology has recently sparked an interest in a variety of areas, including medicine, chemistry, physics, and biology. Nanoparticles (NP) have been used in tumor therapies as appropriate tools for enhancing drug delivery efficacy and enabling therapeutic performance. It is noteworthy, nanomaterial could be reduced the limitation of conventional cancer diagnosis and treatments. Since, the major disadvantages of therapeutic drugs are their insolubility in an aqueous solvent, for instance, paclitaxel (PTX) is one of the important therapeutic agents utilized to treating BC, due to its ability to prevent cancer cell growth. However, its major problem is the poor solubility, which has confirmed to be a challenge when improving stable formulations for BC treatment. In order to reduce this challenge, anti-cancer drugs can be loaded into NPs that can improve water solubility. In our review, we state several nanosystem, which can effective and useful for the diagnosis, treatment of BC. We investigate the function of metal NPs, polymeric NPs, liposomes, and exosomes accompanied therapeutic agents for BC Therapy, and then focused on the potential of nanotechnology to improve conventional approaches in sensing.https://www.mdpi.com/2072-6694/13/9/2214bladder cancernanoparticlestherapydiagnosis |
| spellingShingle | Mahmood Barani Seyedeh Maryam Hosseinikhah Abbas Rahdar Leila Farhoudi Rabia Arshad Magali Cucchiarini Sadanand Pandey Nanotechnology in Bladder Cancer: Diagnosis and Treatment Cancers bladder cancer nanoparticles therapy diagnosis |
| title | Nanotechnology in Bladder Cancer: Diagnosis and Treatment |
| title_full | Nanotechnology in Bladder Cancer: Diagnosis and Treatment |
| title_fullStr | Nanotechnology in Bladder Cancer: Diagnosis and Treatment |
| title_full_unstemmed | Nanotechnology in Bladder Cancer: Diagnosis and Treatment |
| title_short | Nanotechnology in Bladder Cancer: Diagnosis and Treatment |
| title_sort | nanotechnology in bladder cancer diagnosis and treatment |
| topic | bladder cancer nanoparticles therapy diagnosis |
| url | https://www.mdpi.com/2072-6694/13/9/2214 |
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