Effect of Progranulin on Proliferation and Differentiation of Neural Stem/Progenitor Cells after Oxygen/Glucose Deprivation

Effect of Progranulin on Proliferation and Differentiation of Neural Stem/Progenitor Cells after Oxygen/Glucose Deprivation

We previously demonstrated that sivelestat, a selective neutrophil elastase inhibitor, attenuates the cleavage of progranulin (PGRN) and ischemia-induced cell injury in the brain. To obtain further insight into the role of PGRN, in the present study we evaluated the direct effects of sivelestat and...

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Bibliographic Details
Main Authors: Ichiro Horinokita, Hideki Hayashi, Takamasa Nagatomo, Yuna Fushiki, Yui Iwatani, Norio Takagi
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
cerebral ischemia
progranulin
neural stem/progenitor cells
Akt/GSK-3β
neurite outgrowth
Online Access:https://www.mdpi.com/1422-0067/23/4/1949

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