Adverse Childhood Experiences and Methylation of the <i>FKBP5</i> Gene in Patients with Psychotic Disorders
Altered methylation of the <i>FKBP5</i> gene has been observed in various mental disorders and attributed to the effects of adverse childhood experiences (ACEs). However, the level of <i>FKBP5</i> methylation has not been investigated in patients with psychotic disorders. The...
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MDPI AG
2020-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/12/3792 |
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| author | Błażej Misiak Paweł Karpiński Elżbieta Szmida Tomasz Grąźlewski Marcin Jabłoński Katarzyna Cyranka Joanna Rymaszewska Patryk Piotrowski Kamila Kotowicz Dorota Frydecka |
| author_facet | Błażej Misiak Paweł Karpiński Elżbieta Szmida Tomasz Grąźlewski Marcin Jabłoński Katarzyna Cyranka Joanna Rymaszewska Patryk Piotrowski Kamila Kotowicz Dorota Frydecka |
| author_sort | Błażej Misiak |
| collection | DOAJ |
| description | Altered methylation of the <i>FKBP5</i> gene has been observed in various mental disorders and attributed to the effects of adverse childhood experiences (ACEs). However, the level of <i>FKBP5</i> methylation has not been investigated in patients with psychotic disorders. Therefore, in this study we aimed to determine the <i>FKBP5</i> methylation in patients with psychosis and controls, taking into account the effects of ACEs. Participants were 85 patients with psychotic disorders, including first-episode psychosis (FEP) patients and acutely relapsed schizophrenia (SCZ-AR) patients, as well as 56 controls. The level of four CpG sites at the <i>FKBP5</i> gene was determined in the peripheral blood leukocytes using pyrosequencing. After controlling for potential confounding factors, the level of <i>FKBP5</i> methylation at one out of four tested CpG sites was significantly lower in FEP patients compared to other groups of participants. Significant main effects of parental antipathy and sexual abuse on the level of <i>FKBP5</i> methylation were observed at the differentially methylated CpG site. Participants reporting this category of ACEs had significantly lower levels of <i>FKBP5</i> methylation at this CpG site. Lower levels of <i>FKBP5</i> methylation were associated with better cognitive performance and higher functional capacity in patients with psychosis. In controls, lower methylation of <i>FKBP5</i> was related to worse performance of immediate memory and language skills. Our findings suggest that hypomethylation of the <i>FKBP5</i> appears at early stages of psychosis and might be associated with a history of ACEs as well as less severe clinical manifestation. |
| first_indexed | 2024-03-10T14:36:33Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T14:36:33Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-0d3f1e6e90684f93815b5fd0c13d99e02023-11-20T22:04:52ZengMDPI AGJournal of Clinical Medicine2077-03832020-11-01912379210.3390/jcm9123792Adverse Childhood Experiences and Methylation of the <i>FKBP5</i> Gene in Patients with Psychotic DisordersBłażej Misiak0Paweł Karpiński1Elżbieta Szmida2Tomasz Grąźlewski3Marcin Jabłoński4Katarzyna Cyranka5Joanna Rymaszewska6Patryk Piotrowski7Kamila Kotowicz8Dorota Frydecka9Department of Psychiatry, Wroclaw Medical University, Pasteura 10 Street, 50-367 Wroclaw, PolandDepartment of Genetics, Wroclaw Medical University, Marcinkowskiego 1 Street, 50-368 Wroclaw, PolandDepartment of Genetics, Wroclaw Medical University, Marcinkowskiego 1 Street, 50-368 Wroclaw, PolandDepartment of Psychiatry, Pomeranian Medical University, Broniewskiego 26 Street, 71-460 Szczecin, PolandDepartment of Psychiatry, Pomeranian Medical University, Broniewskiego 26 Street, 71-460 Szczecin, PolandDepartment of Psychiatry, Jagiellonian University, Kopernika 21a Street, 31-501 Cracow, PolandDepartment of Psychiatry, Wroclaw Medical University, Pasteura 10 Street, 50-367 Wroclaw, PolandDepartment of Psychiatry, Wroclaw Medical University, Pasteura 10 Street, 50-367 Wroclaw, PolandDepartment of Psychiatry, Wroclaw Medical University, Pasteura 10 Street, 50-367 Wroclaw, PolandDepartment of Psychiatry, Wroclaw Medical University, Pasteura 10 Street, 50-367 Wroclaw, PolandAltered methylation of the <i>FKBP5</i> gene has been observed in various mental disorders and attributed to the effects of adverse childhood experiences (ACEs). However, the level of <i>FKBP5</i> methylation has not been investigated in patients with psychotic disorders. Therefore, in this study we aimed to determine the <i>FKBP5</i> methylation in patients with psychosis and controls, taking into account the effects of ACEs. Participants were 85 patients with psychotic disorders, including first-episode psychosis (FEP) patients and acutely relapsed schizophrenia (SCZ-AR) patients, as well as 56 controls. The level of four CpG sites at the <i>FKBP5</i> gene was determined in the peripheral blood leukocytes using pyrosequencing. After controlling for potential confounding factors, the level of <i>FKBP5</i> methylation at one out of four tested CpG sites was significantly lower in FEP patients compared to other groups of participants. Significant main effects of parental antipathy and sexual abuse on the level of <i>FKBP5</i> methylation were observed at the differentially methylated CpG site. Participants reporting this category of ACEs had significantly lower levels of <i>FKBP5</i> methylation at this CpG site. Lower levels of <i>FKBP5</i> methylation were associated with better cognitive performance and higher functional capacity in patients with psychosis. In controls, lower methylation of <i>FKBP5</i> was related to worse performance of immediate memory and language skills. Our findings suggest that hypomethylation of the <i>FKBP5</i> appears at early stages of psychosis and might be associated with a history of ACEs as well as less severe clinical manifestation.https://www.mdpi.com/2077-0383/9/12/3792epigeneticsearly-life stresschildhood traumachildhood maltreatmentcortisol |
| spellingShingle | Błażej Misiak Paweł Karpiński Elżbieta Szmida Tomasz Grąźlewski Marcin Jabłoński Katarzyna Cyranka Joanna Rymaszewska Patryk Piotrowski Kamila Kotowicz Dorota Frydecka Adverse Childhood Experiences and Methylation of the <i>FKBP5</i> Gene in Patients with Psychotic Disorders Journal of Clinical Medicine epigenetics early-life stress childhood trauma childhood maltreatment cortisol |
| title | Adverse Childhood Experiences and Methylation of the <i>FKBP5</i> Gene in Patients with Psychotic Disorders |
| title_full | Adverse Childhood Experiences and Methylation of the <i>FKBP5</i> Gene in Patients with Psychotic Disorders |
| title_fullStr | Adverse Childhood Experiences and Methylation of the <i>FKBP5</i> Gene in Patients with Psychotic Disorders |
| title_full_unstemmed | Adverse Childhood Experiences and Methylation of the <i>FKBP5</i> Gene in Patients with Psychotic Disorders |
| title_short | Adverse Childhood Experiences and Methylation of the <i>FKBP5</i> Gene in Patients with Psychotic Disorders |
| title_sort | adverse childhood experiences and methylation of the i fkbp5 i gene in patients with psychotic disorders |
| topic | epigenetics early-life stress childhood trauma childhood maltreatment cortisol |
| url | https://www.mdpi.com/2077-0383/9/12/3792 |
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