Particulate matter exposure and neurodegenerative diseases: A comprehensive update on toxicity and mechanisms
Exposure to particulate matter (PM) has been associated with a range of health impacts, including neurological abnormalities that affect neurodevelopment, neuroplasticity, and behavior. Recently, there has been growing interest in investigating the possible relationship between PM exposure and the o...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323010692 |
| _version_ | 1797643575161257984 |
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| author | Jeongmin Lee Poornima D.E. Weerasinghe-Mudiyanselage Bohye Kim Sohi Kang Joong-Sun Kim Changjong Moon |
| author_facet | Jeongmin Lee Poornima D.E. Weerasinghe-Mudiyanselage Bohye Kim Sohi Kang Joong-Sun Kim Changjong Moon |
| author_sort | Jeongmin Lee |
| collection | DOAJ |
| description | Exposure to particulate matter (PM) has been associated with a range of health impacts, including neurological abnormalities that affect neurodevelopment, neuroplasticity, and behavior. Recently, there has been growing interest in investigating the possible relationship between PM exposure and the onset and progression of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and multiple sclerosis. However, the precise mechanism by which PM affects neurodegeneration is still unclear, even though several epidemiological and animal model studies have provided mechanistic insights. This article presents a review of the current research on the neurotoxicity of PM and its impact on neurodegenerative diseases. This review summarizes findings from epidemiological and animal model studies collected through searches in Google Scholar, PubMed, Web of Science, and Scopus. This review paper also discusses the reported effects of PM exposure on the central nervous system and highlights research gaps and future directions. The information presented in this review may inform public health policies aimed at reducing PM exposure and may contribute to the development of new treatments for neurodegenerative diseases. Further mechanistic and therapeutic research will be needed to fully understand the relationship between PM exposure and neurodegenerative diseases. |
| first_indexed | 2024-03-11T14:16:48Z |
| format | Article |
| id | doaj.art-0d3fbc267d7c47a0a2dc31f401446c6e |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-03-11T14:16:48Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-0d3fbc267d7c47a0a2dc31f401446c6e2023-11-01T04:45:54ZengElsevierEcotoxicology and Environmental Safety0147-65132023-11-01266115565Particulate matter exposure and neurodegenerative diseases: A comprehensive update on toxicity and mechanismsJeongmin Lee0Poornima D.E. Weerasinghe-Mudiyanselage1Bohye Kim2Sohi Kang3Joong-Sun Kim4Changjong Moon5Department of Veterinary Anatomy and Animal Behavior, College of Veterinary Medicine and BK21 FOUR program, Chonnam National University, Gwangju 61186, South KoreaDepartment of Veterinary Anatomy and Animal Behavior, College of Veterinary Medicine and BK21 FOUR program, Chonnam National University, Gwangju 61186, South KoreaDepartment of Veterinary Anatomy and Animal Behavior, College of Veterinary Medicine and BK21 FOUR program, Chonnam National University, Gwangju 61186, South KoreaDepartment of Veterinary Anatomy and Animal Behavior, College of Veterinary Medicine and BK21 FOUR program, Chonnam National University, Gwangju 61186, South KoreaDepartment of Veterinary Anatomy and Animal Behavior, College of Veterinary Medicine and BK21 FOUR program, Chonnam National University, Gwangju 61186, South KoreaCorrespondence to: Department of Veterinary Anatomy, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, South Korea.; Department of Veterinary Anatomy and Animal Behavior, College of Veterinary Medicine and BK21 FOUR program, Chonnam National University, Gwangju 61186, South KoreaExposure to particulate matter (PM) has been associated with a range of health impacts, including neurological abnormalities that affect neurodevelopment, neuroplasticity, and behavior. Recently, there has been growing interest in investigating the possible relationship between PM exposure and the onset and progression of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and multiple sclerosis. However, the precise mechanism by which PM affects neurodegeneration is still unclear, even though several epidemiological and animal model studies have provided mechanistic insights. This article presents a review of the current research on the neurotoxicity of PM and its impact on neurodegenerative diseases. This review summarizes findings from epidemiological and animal model studies collected through searches in Google Scholar, PubMed, Web of Science, and Scopus. This review paper also discusses the reported effects of PM exposure on the central nervous system and highlights research gaps and future directions. The information presented in this review may inform public health policies aimed at reducing PM exposure and may contribute to the development of new treatments for neurodegenerative diseases. Further mechanistic and therapeutic research will be needed to fully understand the relationship between PM exposure and neurodegenerative diseases.http://www.sciencedirect.com/science/article/pii/S0147651323010692Central nervous systemNeurodegenerative diseasesNeurotoxicityParticulate matterPublic healthTherapeutic development |
| spellingShingle | Jeongmin Lee Poornima D.E. Weerasinghe-Mudiyanselage Bohye Kim Sohi Kang Joong-Sun Kim Changjong Moon Particulate matter exposure and neurodegenerative diseases: A comprehensive update on toxicity and mechanisms Ecotoxicology and Environmental Safety Central nervous system Neurodegenerative diseases Neurotoxicity Particulate matter Public health Therapeutic development |
| title | Particulate matter exposure and neurodegenerative diseases: A comprehensive update on toxicity and mechanisms |
| title_full | Particulate matter exposure and neurodegenerative diseases: A comprehensive update on toxicity and mechanisms |
| title_fullStr | Particulate matter exposure and neurodegenerative diseases: A comprehensive update on toxicity and mechanisms |
| title_full_unstemmed | Particulate matter exposure and neurodegenerative diseases: A comprehensive update on toxicity and mechanisms |
| title_short | Particulate matter exposure and neurodegenerative diseases: A comprehensive update on toxicity and mechanisms |
| title_sort | particulate matter exposure and neurodegenerative diseases a comprehensive update on toxicity and mechanisms |
| topic | Central nervous system Neurodegenerative diseases Neurotoxicity Particulate matter Public health Therapeutic development |
| url | http://www.sciencedirect.com/science/article/pii/S0147651323010692 |
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