Exploring the current molecular landscape and management of multiple myeloma patients with the t(11;14) translocation

Exploring the current molecular landscape and management of multiple myeloma patients with the t(11;14) translocation

Multiple myeloma (MM) is a genetically complex disease. The key myeloma-initiating genetic events are hyperdiploidy and translocations involving the immunoglobulin heavy chain (IgH) enhancer on chromosome 14, which leads to the activation of oncogenes (e.g., CCND1, CCND3, MAF, and MMSET). The t(11;1...

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Bibliographic Details
Main Authors: Michael D. Diamantidis, Sofia Papadaki, Evdoxia Hatjiharissi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
Keywords: translocation t(11;14)
multiple myeloma
precision medicine
BCL-2
venetoclax
genetic abnormalities
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.934008/full

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