Association between Abdominal Obesity and Incident Colorectal Cancer: A Nationwide Cohort Study in Korea
Background: We investigated the association of w May aist circumference (WC) and abdominal obesity with the incident colorectal cancer risk in Korean adults. Methods: This nationwide population-based cohort study was based on health insurance claims data. We analyzed data from 9,959,605 participants...
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| Format: | Article |
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MDPI AG
2020-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/6/1368 |
| _version_ | 1797566927454863360 |
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| author | Ga Eun Nam Se-Jin Baek Hong Bae Choi Kyungdo Han Jung-Myun Kwak Jin Kim Seon-Hahn Kim |
| author_facet | Ga Eun Nam Se-Jin Baek Hong Bae Choi Kyungdo Han Jung-Myun Kwak Jin Kim Seon-Hahn Kim |
| author_sort | Ga Eun Nam |
| collection | DOAJ |
| description | Background: We investigated the association of w May aist circumference (WC) and abdominal obesity with the incident colorectal cancer risk in Korean adults. Methods: This nationwide population-based cohort study was based on health insurance claims data. We analyzed data from 9,959,605 participants acquired through health check-ups of the Korean National Health Insurance Service in 2009 who were followed up until the end of 2017. We performed multivariable Cox proportional hazards regression analysis. Results: During 8.3 years of follow up, 101,197 cases (1.0%) of colorectal cancer were recorded. After adjusting for potential confounders, there was a positive association between WC and colorectal cancer risk (<i>p</i> for trend <0.001). Abdominal obesity was associated with an increased risk of colorectal (hazard ratio: 1.10, (95% confidence interval: 1.08–1.12)), colon (1.11, 1.09–1.13), and rectal cancer (1.08, 1.05–1.10). These associations were independent of body mass index and were more pronounced in men and elderly individuals. Conclusion: We revealed that higher WC is related to colorectal cancer risk, thus suggesting that abdominal obesity may be a risk factor for colorectal cancer in this East Asian population. |
| first_indexed | 2024-03-10T19:34:21Z |
| format | Article |
| id | doaj.art-0d43f270fc1c4d44b465c839d5858557 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T19:34:21Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-0d43f270fc1c4d44b465c839d58585572023-11-20T01:49:51ZengMDPI AGCancers2072-66942020-05-01126136810.3390/cancers12061368Association between Abdominal Obesity and Incident Colorectal Cancer: A Nationwide Cohort Study in KoreaGa Eun Nam0Se-Jin Baek1Hong Bae Choi2Kyungdo Han3Jung-Myun Kwak4Jin Kim5Seon-Hahn Kim6Department of Family Medicine, College of Medicine, Korea University, Seoul 02841, KoreaDepartment of Surgery, College of Medicine, Korea University, Seoul 02841, KoreaDepartment of Surgery, College of Medicine, Korea University, Seoul 02841, KoreaDepartment of Statistics and Actuarial Science, Soongsil University, Seoul 06978, KoreaDepartment of Surgery, College of Medicine, Korea University, Seoul 02841, KoreaDepartment of Surgery, College of Medicine, Korea University, Seoul 02841, KoreaDepartment of Surgery, College of Medicine, Korea University, Seoul 02841, KoreaBackground: We investigated the association of w May aist circumference (WC) and abdominal obesity with the incident colorectal cancer risk in Korean adults. Methods: This nationwide population-based cohort study was based on health insurance claims data. We analyzed data from 9,959,605 participants acquired through health check-ups of the Korean National Health Insurance Service in 2009 who were followed up until the end of 2017. We performed multivariable Cox proportional hazards regression analysis. Results: During 8.3 years of follow up, 101,197 cases (1.0%) of colorectal cancer were recorded. After adjusting for potential confounders, there was a positive association between WC and colorectal cancer risk (<i>p</i> for trend <0.001). Abdominal obesity was associated with an increased risk of colorectal (hazard ratio: 1.10, (95% confidence interval: 1.08–1.12)), colon (1.11, 1.09–1.13), and rectal cancer (1.08, 1.05–1.10). These associations were independent of body mass index and were more pronounced in men and elderly individuals. Conclusion: We revealed that higher WC is related to colorectal cancer risk, thus suggesting that abdominal obesity may be a risk factor for colorectal cancer in this East Asian population.https://www.mdpi.com/2072-6694/12/6/1368abdominal obesitywaist circumferencecolorectal neoplasmbody mass index |
| spellingShingle | Ga Eun Nam Se-Jin Baek Hong Bae Choi Kyungdo Han Jung-Myun Kwak Jin Kim Seon-Hahn Kim Association between Abdominal Obesity and Incident Colorectal Cancer: A Nationwide Cohort Study in Korea Cancers abdominal obesity waist circumference colorectal neoplasm body mass index |
| title | Association between Abdominal Obesity and Incident Colorectal Cancer: A Nationwide Cohort Study in Korea |
| title_full | Association between Abdominal Obesity and Incident Colorectal Cancer: A Nationwide Cohort Study in Korea |
| title_fullStr | Association between Abdominal Obesity and Incident Colorectal Cancer: A Nationwide Cohort Study in Korea |
| title_full_unstemmed | Association between Abdominal Obesity and Incident Colorectal Cancer: A Nationwide Cohort Study in Korea |
| title_short | Association between Abdominal Obesity and Incident Colorectal Cancer: A Nationwide Cohort Study in Korea |
| title_sort | association between abdominal obesity and incident colorectal cancer a nationwide cohort study in korea |
| topic | abdominal obesity waist circumference colorectal neoplasm body mass index |
| url | https://www.mdpi.com/2072-6694/12/6/1368 |
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