Contribution of Inhibitory Metabolites and Competition for Nutrients to Colonization Resistance against <i>Clostridioides difficile</i> by Commensal <i>Clostridium</i>
<i>Clostridioides difficile</i> is an anaerobic pathogen that causes significant morbidity and mortality. Understanding the mechanisms of colonization resistance against <i>C. difficile</i> is important for elucidating the mechanisms by which <i>C. difficile</i> i...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/9/2/371 |
| Summary: | <i>Clostridioides difficile</i> is an anaerobic pathogen that causes significant morbidity and mortality. Understanding the mechanisms of colonization resistance against <i>C. difficile</i> is important for elucidating the mechanisms by which <i>C. difficile</i> is able to colonize the gut after antibiotics. Commensal <i>Clostridium</i> play a key role in colonization resistance. They are able to modify bile acids which alter the <i>C. difficile</i> life cycle. Commensal <i>Clostridium</i> also produce other inhibitory metabolites including antimicrobials and short chain fatty acids. They also compete with <i>C. difficile</i> for vital nutrients such as proline. Understanding the mechanistic effects that these metabolites have on <i>C. difficile</i> and other gut pathogens is important for the development of new therapeutics against <i>C. difficile</i> infection (CDI), which are urgently needed. |
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| ISSN: | 2076-2607 |