Programmed death ligand-1 and CD8 tumor-infiltrating lymphocytes (TILs) as prognostic predictors in ovarian high-grade serous carcinoma (HGSC)
Abstract Background P D-L1 is expressed in tumor cells and plays a crucial role in tumor immune escape. Tumor-infiltrating lymphocytes (TILs) as CD8 T cells contribute to reduced tumor growth. Few studies investigated the prognostic effect of PD-L1 and CD8 TILs in ovarian high-grade serous carcinoma...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2021-07-01
|
| Series: | Journal of the Egyptian National Cancer Institute |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43046-021-00073-5 |
| _version_ | 1818859583941115904 |
|---|---|
| author | Mayada Saad Farrag Khaled Abdelwahab Nesrine Saad Farrag Waleed Elsayed Elrefaie Ziad Emarah |
| author_facet | Mayada Saad Farrag Khaled Abdelwahab Nesrine Saad Farrag Waleed Elsayed Elrefaie Ziad Emarah |
| author_sort | Mayada Saad Farrag |
| collection | DOAJ |
| description | Abstract Background P D-L1 is expressed in tumor cells and plays a crucial role in tumor immune escape. Tumor-infiltrating lymphocytes (TILs) as CD8 T cells contribute to reduced tumor growth. Few studies investigated the prognostic effect of PD-L1 and CD8 TILs in ovarian high-grade serous carcinoma (HGSC). In the present study, we analyzed the expression of PD-L1 and CD8 TILs in HGSC by immunohistochemistry, and results were correlated to prognosis. It was carried on 54 cases of ovarian HGSC who attended the Oncology Centre, Mansoura University, Egypt, from 2012 till 2019. Results Nearly 60% of cases showed positive PD-L1 expression in tumor cells. Regarding the clinicopathological characteristics, higher PD-L1 expression was found among patients with residual tumor (82.4%) compared to patients with no residual tumor (54.5%), with marginal statistical significance (p 0.07). PD-L1 was significantly associated with CD8 TILs expression. Higher PD-L1 expression was found among tumors with low expression of CD8 TILs with statistically significant difference (p≤0.001). Disease-free survival (DFS) was significantly lower among the group with positive expression of PD-L1 compared to the group with negative expression of PD-L1 (p 0.01), while overall survival (OS) was not associated with PD-L1 expression. On the other hand, the overall survival (OS) in patients with high CD8 expression was significantly higher than patients with low CD8 expression (p 0.043), while DFS was not significantly different among both CD8 TILS groups. Conclusions PD-L1 and CD8 TILs may become a promising therapeutic target for patients with ovarian HGSC. More studies are needed to further validate their prognostic effect. Precise identification of patients who will benefit from PD-L1 checkpoint blockade and TILs adaptive immunotherapy is mandatory. |
| first_indexed | 2024-12-19T09:14:30Z |
| format | Article |
| id | doaj.art-0d45f8825ea94bb88de08d467b6cef83 |
| institution | Directory Open Access Journal |
| issn | 2589-0409 |
| language | English |
| last_indexed | 2024-12-19T09:14:30Z |
| publishDate | 2021-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of the Egyptian National Cancer Institute |
| spelling | doaj.art-0d45f8825ea94bb88de08d467b6cef832022-12-21T20:28:07ZengSpringerOpenJournal of the Egyptian National Cancer Institute2589-04092021-07-0133111010.1186/s43046-021-00073-5Programmed death ligand-1 and CD8 tumor-infiltrating lymphocytes (TILs) as prognostic predictors in ovarian high-grade serous carcinoma (HGSC)Mayada Saad Farrag0Khaled Abdelwahab1Nesrine Saad Farrag2Waleed Elsayed Elrefaie3Ziad Emarah4Department of Pathology, Faculty of Medicine, Port Said UniversityDepartment of Surgical Oncology, Mansoura Oncology Center, Mansoura UniversityDepartment of Community Medicine and Public Health, Faculty of Medicine, Mansoura UniversityDepartment of Obstetrics and Gynecology, Port Said Faculty of Medicine, Port Said UniversityDepartment of Medical Oncology, Mansoura Oncology Center, Mansoura UniversityAbstract Background P D-L1 is expressed in tumor cells and plays a crucial role in tumor immune escape. Tumor-infiltrating lymphocytes (TILs) as CD8 T cells contribute to reduced tumor growth. Few studies investigated the prognostic effect of PD-L1 and CD8 TILs in ovarian high-grade serous carcinoma (HGSC). In the present study, we analyzed the expression of PD-L1 and CD8 TILs in HGSC by immunohistochemistry, and results were correlated to prognosis. It was carried on 54 cases of ovarian HGSC who attended the Oncology Centre, Mansoura University, Egypt, from 2012 till 2019. Results Nearly 60% of cases showed positive PD-L1 expression in tumor cells. Regarding the clinicopathological characteristics, higher PD-L1 expression was found among patients with residual tumor (82.4%) compared to patients with no residual tumor (54.5%), with marginal statistical significance (p 0.07). PD-L1 was significantly associated with CD8 TILs expression. Higher PD-L1 expression was found among tumors with low expression of CD8 TILs with statistically significant difference (p≤0.001). Disease-free survival (DFS) was significantly lower among the group with positive expression of PD-L1 compared to the group with negative expression of PD-L1 (p 0.01), while overall survival (OS) was not associated with PD-L1 expression. On the other hand, the overall survival (OS) in patients with high CD8 expression was significantly higher than patients with low CD8 expression (p 0.043), while DFS was not significantly different among both CD8 TILS groups. Conclusions PD-L1 and CD8 TILs may become a promising therapeutic target for patients with ovarian HGSC. More studies are needed to further validate their prognostic effect. Precise identification of patients who will benefit from PD-L1 checkpoint blockade and TILs adaptive immunotherapy is mandatory.https://doi.org/10.1186/s43046-021-00073-5CD8HGSCImmunotherapyPD-L1TILs |
| spellingShingle | Mayada Saad Farrag Khaled Abdelwahab Nesrine Saad Farrag Waleed Elsayed Elrefaie Ziad Emarah Programmed death ligand-1 and CD8 tumor-infiltrating lymphocytes (TILs) as prognostic predictors in ovarian high-grade serous carcinoma (HGSC) Journal of the Egyptian National Cancer Institute CD8 HGSC Immunotherapy PD-L1 TILs |
| title | Programmed death ligand-1 and CD8 tumor-infiltrating lymphocytes (TILs) as prognostic predictors in ovarian high-grade serous carcinoma (HGSC) |
| title_full | Programmed death ligand-1 and CD8 tumor-infiltrating lymphocytes (TILs) as prognostic predictors in ovarian high-grade serous carcinoma (HGSC) |
| title_fullStr | Programmed death ligand-1 and CD8 tumor-infiltrating lymphocytes (TILs) as prognostic predictors in ovarian high-grade serous carcinoma (HGSC) |
| title_full_unstemmed | Programmed death ligand-1 and CD8 tumor-infiltrating lymphocytes (TILs) as prognostic predictors in ovarian high-grade serous carcinoma (HGSC) |
| title_short | Programmed death ligand-1 and CD8 tumor-infiltrating lymphocytes (TILs) as prognostic predictors in ovarian high-grade serous carcinoma (HGSC) |
| title_sort | programmed death ligand 1 and cd8 tumor infiltrating lymphocytes tils as prognostic predictors in ovarian high grade serous carcinoma hgsc |
| topic | CD8 HGSC Immunotherapy PD-L1 TILs |
| url | https://doi.org/10.1186/s43046-021-00073-5 |
| work_keys_str_mv | AT mayadasaadfarrag programmeddeathligand1andcd8tumorinfiltratinglymphocytestilsasprognosticpredictorsinovarianhighgradeserouscarcinomahgsc AT khaledabdelwahab programmeddeathligand1andcd8tumorinfiltratinglymphocytestilsasprognosticpredictorsinovarianhighgradeserouscarcinomahgsc AT nesrinesaadfarrag programmeddeathligand1andcd8tumorinfiltratinglymphocytestilsasprognosticpredictorsinovarianhighgradeserouscarcinomahgsc AT waleedelsayedelrefaie programmeddeathligand1andcd8tumorinfiltratinglymphocytestilsasprognosticpredictorsinovarianhighgradeserouscarcinomahgsc AT ziademarah programmeddeathligand1andcd8tumorinfiltratinglymphocytestilsasprognosticpredictorsinovarianhighgradeserouscarcinomahgsc |