Liver injury in COVID-19: an insight into pathobiology and roles of risk factors
Abstract COVID-19 is a complex disease that can lead to fatal respiratory failure with extrapulmonary complications, either as a direct result of viral invasion in multiple organs or secondary to oxygen supply shortage. Liver is susceptible to many viral pathogens, and due to its versatile functions...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-03-01
|
| Series: | Virology Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12985-024-02332-y |
| _version_ | 1797259472220979200 |
|---|---|
| author | Abbas Tazarghi Sahar Bazoq Mohammad Hosein Taziki Balajelini Mohsen Ebrahimi Seyed Mehran Hosseini Hadi Razavi Nikoo |
| author_facet | Abbas Tazarghi Sahar Bazoq Mohammad Hosein Taziki Balajelini Mohsen Ebrahimi Seyed Mehran Hosseini Hadi Razavi Nikoo |
| author_sort | Abbas Tazarghi |
| collection | DOAJ |
| description | Abstract COVID-19 is a complex disease that can lead to fatal respiratory failure with extrapulmonary complications, either as a direct result of viral invasion in multiple organs or secondary to oxygen supply shortage. Liver is susceptible to many viral pathogens, and due to its versatile functions in the body, it is of great interest to determine how hepatocytes may interact with SARS-CoV-2 in COVID-19 patients. Liver injury is a major cause of death, and SARS-CoV-2 is suspected to contribute significantly to hepatopathy. Owing to the lack of knowledge in this field, further research is required to address these ambiguities. Therefore, we aimed to provide a comprehensive insight into host-virus interactions, underlying mechanisms, and associated risk factors by collecting results from epidemiological analyses and relevant laboratory experiments. Backed by an avalanche of recent studies, our findings support that liver injury is a sequela of severe COVID-19, and certain pre-existing liver conditions can also intensify the morbidity of SARS-CoV-2 infection in synergy. Notably, age, sex, lifestyle, dietary habits, coinfection, and particular drug regimens play a decisive role in the final outcome and prognosis as well. Taken together, our goal was to unravel these complexities concerning the development of novel diagnostic, prophylactic, and therapeutic approaches with a focus on prioritizing high-risk groups. |
| first_indexed | 2024-04-24T23:09:58Z |
| format | Article |
| id | doaj.art-0d4698238cc44aa08a270a6d331461e6 |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-04-24T23:09:58Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-0d4698238cc44aa08a270a6d331461e62024-03-17T12:14:25ZengBMCVirology Journal1743-422X2024-03-0121111310.1186/s12985-024-02332-yLiver injury in COVID-19: an insight into pathobiology and roles of risk factorsAbbas Tazarghi0Sahar Bazoq1Mohammad Hosein Taziki Balajelini2Mohsen Ebrahimi3Seyed Mehran Hosseini4Hadi Razavi Nikoo5Department of Microbiology, Faculty of Medicine, Golestan University of Medical SciencesDepartment of Microbiology, Faculty of Medicine, Golestan University of Medical SciencesDepartment of Otorhinolaryngology, Neuroscience Research Center, School of Medicine, Golestan University of Medical SciencesNeonatal and Children’s Health Research Center, Golestan University of Medical SciencesDepartment of Physiology, School of Medicine, Neuroscience Research Center, Golestan University of Medical SciencesDepartment of Microbiology, Faculty of Medicine, Golestan University of Medical SciencesAbstract COVID-19 is a complex disease that can lead to fatal respiratory failure with extrapulmonary complications, either as a direct result of viral invasion in multiple organs or secondary to oxygen supply shortage. Liver is susceptible to many viral pathogens, and due to its versatile functions in the body, it is of great interest to determine how hepatocytes may interact with SARS-CoV-2 in COVID-19 patients. Liver injury is a major cause of death, and SARS-CoV-2 is suspected to contribute significantly to hepatopathy. Owing to the lack of knowledge in this field, further research is required to address these ambiguities. Therefore, we aimed to provide a comprehensive insight into host-virus interactions, underlying mechanisms, and associated risk factors by collecting results from epidemiological analyses and relevant laboratory experiments. Backed by an avalanche of recent studies, our findings support that liver injury is a sequela of severe COVID-19, and certain pre-existing liver conditions can also intensify the morbidity of SARS-CoV-2 infection in synergy. Notably, age, sex, lifestyle, dietary habits, coinfection, and particular drug regimens play a decisive role in the final outcome and prognosis as well. Taken together, our goal was to unravel these complexities concerning the development of novel diagnostic, prophylactic, and therapeutic approaches with a focus on prioritizing high-risk groups.https://doi.org/10.1186/s12985-024-02332-ySARS-CoV-2COVID-19Liver injuryRisk factorsPathobiology mechanisms |
| spellingShingle | Abbas Tazarghi Sahar Bazoq Mohammad Hosein Taziki Balajelini Mohsen Ebrahimi Seyed Mehran Hosseini Hadi Razavi Nikoo Liver injury in COVID-19: an insight into pathobiology and roles of risk factors Virology Journal SARS-CoV-2 COVID-19 Liver injury Risk factors Pathobiology mechanisms |
| title | Liver injury in COVID-19: an insight into pathobiology and roles of risk factors |
| title_full | Liver injury in COVID-19: an insight into pathobiology and roles of risk factors |
| title_fullStr | Liver injury in COVID-19: an insight into pathobiology and roles of risk factors |
| title_full_unstemmed | Liver injury in COVID-19: an insight into pathobiology and roles of risk factors |
| title_short | Liver injury in COVID-19: an insight into pathobiology and roles of risk factors |
| title_sort | liver injury in covid 19 an insight into pathobiology and roles of risk factors |
| topic | SARS-CoV-2 COVID-19 Liver injury Risk factors Pathobiology mechanisms |
| url | https://doi.org/10.1186/s12985-024-02332-y |
| work_keys_str_mv | AT abbastazarghi liverinjuryincovid19aninsightintopathobiologyandrolesofriskfactors AT saharbazoq liverinjuryincovid19aninsightintopathobiologyandrolesofriskfactors AT mohammadhoseintazikibalajelini liverinjuryincovid19aninsightintopathobiologyandrolesofriskfactors AT mohsenebrahimi liverinjuryincovid19aninsightintopathobiologyandrolesofriskfactors AT seyedmehranhosseini liverinjuryincovid19aninsightintopathobiologyandrolesofriskfactors AT hadirazavinikoo liverinjuryincovid19aninsightintopathobiologyandrolesofriskfactors |