Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology
With the increase of life expectancy, neurodegenerative disorders are becoming not only a health but also a social burden worldwide. However, due to the multitude of pathophysiological disease states, current treatments fail to meet the desired outcomes. Therefore, there is a need for new therapeuti...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/7/1350 |
| _version_ | 1818479342962868224 |
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| author | Rui S. Rodrigues Diogo M. Lourenço Sara L. Paulo Joana M. Mateus Miguel F. Ferreira Francisco M. Mouro João B. Moreira Filipa F. Ribeiro Ana M. Sebastião Sara Xapelli |
| author_facet | Rui S. Rodrigues Diogo M. Lourenço Sara L. Paulo Joana M. Mateus Miguel F. Ferreira Francisco M. Mouro João B. Moreira Filipa F. Ribeiro Ana M. Sebastião Sara Xapelli |
| author_sort | Rui S. Rodrigues |
| collection | DOAJ |
| description | With the increase of life expectancy, neurodegenerative disorders are becoming not only a health but also a social burden worldwide. However, due to the multitude of pathophysiological disease states, current treatments fail to meet the desired outcomes. Therefore, there is a need for new therapeutic strategies focusing on more integrated, personalized and effective approaches. The prospect of using neural stem cells (NSC) as regenerative therapies is very promising, however several issues still need to be addressed. In particular, the potential actions of pharmacological agents used to modulate NSC activity are highly relevant. With the ongoing discussion of cannabinoid usage for medical purposes and reports drawing attention to the effects of cannabinoids on NSC regulation, there is an enormous, and yet, uncovered potential for cannabinoids as treatment options for several neurological disorders, specifically when combined with stem cell therapy. In this manuscript, we review in detail how cannabinoids act as potent regulators of NSC biology and their potential to modulate several neurogenic features in the context of pathophysiology. |
| first_indexed | 2024-12-10T11:09:20Z |
| format | Article |
| id | doaj.art-0d48ce5ecb2b492c99ff1ec4799cabea |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-10T11:09:20Z |
| publishDate | 2019-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-0d48ce5ecb2b492c99ff1ec4799cabea2022-12-22T01:51:27ZengMDPI AGMolecules1420-30492019-04-01247135010.3390/molecules24071350molecules24071350Cannabinoid Actions on Neural Stem Cells: Implications for PathophysiologyRui S. Rodrigues0Diogo M. Lourenço1Sara L. Paulo2Joana M. Mateus3Miguel F. Ferreira4Francisco M. Mouro5João B. Moreira6Filipa F. Ribeiro7Ana M. Sebastião8Sara Xapelli9Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Lisboa, 1649-028 Lisboa, PortugalInstituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Lisboa, 1649-028 Lisboa, PortugalInstituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Lisboa, 1649-028 Lisboa, PortugalInstituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Lisboa, 1649-028 Lisboa, PortugalInstituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Lisboa, 1649-028 Lisboa, PortugalInstituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Lisboa, 1649-028 Lisboa, PortugalInstituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Lisboa, 1649-028 Lisboa, PortugalInstituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Lisboa, 1649-028 Lisboa, PortugalInstituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Lisboa, 1649-028 Lisboa, PortugalInstituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Lisboa, 1649-028 Lisboa, PortugalWith the increase of life expectancy, neurodegenerative disorders are becoming not only a health but also a social burden worldwide. However, due to the multitude of pathophysiological disease states, current treatments fail to meet the desired outcomes. Therefore, there is a need for new therapeutic strategies focusing on more integrated, personalized and effective approaches. The prospect of using neural stem cells (NSC) as regenerative therapies is very promising, however several issues still need to be addressed. In particular, the potential actions of pharmacological agents used to modulate NSC activity are highly relevant. With the ongoing discussion of cannabinoid usage for medical purposes and reports drawing attention to the effects of cannabinoids on NSC regulation, there is an enormous, and yet, uncovered potential for cannabinoids as treatment options for several neurological disorders, specifically when combined with stem cell therapy. In this manuscript, we review in detail how cannabinoids act as potent regulators of NSC biology and their potential to modulate several neurogenic features in the context of pathophysiology.https://www.mdpi.com/1420-3049/24/7/1350cannabinoidsneural stem cellsneurogenesisregenerationpathophysiology |
| spellingShingle | Rui S. Rodrigues Diogo M. Lourenço Sara L. Paulo Joana M. Mateus Miguel F. Ferreira Francisco M. Mouro João B. Moreira Filipa F. Ribeiro Ana M. Sebastião Sara Xapelli Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology Molecules cannabinoids neural stem cells neurogenesis regeneration pathophysiology |
| title | Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology |
| title_full | Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology |
| title_fullStr | Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology |
| title_full_unstemmed | Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology |
| title_short | Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology |
| title_sort | cannabinoid actions on neural stem cells implications for pathophysiology |
| topic | cannabinoids neural stem cells neurogenesis regeneration pathophysiology |
| url | https://www.mdpi.com/1420-3049/24/7/1350 |
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