An Analysis of the Infections and Determination of Empiric Antibiotic Therapy in Cats and Dogs with Cancer-Associated Infections
Cancer patients commonly develop infectious complications over the course of the disease. One thousand patients receiving treatment for an oncologic disease at a single veterinary teaching hospital were retrospectively reviewed for concurrent infections. A total of 153 confirmed bacterial infections...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/10/6/700 |
| _version_ | 1797530437708414976 |
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| author | Katie Curran Haley Leeper Kathy O’Reilly Joelle Jacob Luiz E. Bermudez |
| author_facet | Katie Curran Haley Leeper Kathy O’Reilly Joelle Jacob Luiz E. Bermudez |
| author_sort | Katie Curran |
| collection | DOAJ |
| description | Cancer patients commonly develop infectious complications over the course of the disease. One thousand patients receiving treatment for an oncologic disease at a single veterinary teaching hospital were retrospectively reviewed for concurrent infections. A total of 153 confirmed bacterial infections were identified, 82 of which were abscesses or wounds, 13 of which were respiratory infections, 3 of which were ear infections, and 55 of which were urinary tract infections. It was observed that the majority of the infections were caused by bacteria that are normally associated with that specific site location. <i>Escherichia coli</i> was the most common pathogen linked to infections in general, but <i>Staphylococcus pseudintermedius</i> was a frequently identified pathogen associated with wound infections. The susceptibility to diverse antimicrobials varied with the site of infection. Eleven cases (7.1%) were caused by opportunistic infections of the site, and <i>E. coli</i> and <i>Pseudomonas aeruginosa</i> were the pathogens isolated. Those bacteria were resistant to many antibiotics but showed susceptibility to aminoglycosides, imipenem, quinolones, and polymyxin B. In conclusion, veterinary patients with cancer or those under treatment for tumors develop infections by commonly encountered bacteria in the different sites of the body, with a susceptibility to antibiotics that is not out of line from what is expected. A small subset of cases developed opportunistic infections, with microbes that were more resistant to many classes of antibiotics. |
| first_indexed | 2024-03-10T10:28:57Z |
| format | Article |
| id | doaj.art-0d4bcc94f75b43b5bf9a66ebf06ce464 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T10:28:57Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-0d4bcc94f75b43b5bf9a66ebf06ce4642023-11-21T23:44:28ZengMDPI AGAntibiotics2079-63822021-06-0110670010.3390/antibiotics10060700An Analysis of the Infections and Determination of Empiric Antibiotic Therapy in Cats and Dogs with Cancer-Associated InfectionsKatie Curran0Haley Leeper1Kathy O’Reilly2Joelle Jacob3Luiz E. Bermudez4Department of Clinical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USADepartment of Clinical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USADepartment of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USAOregon Veterinary Diagnostic Laboratory, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USADepartment of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USACancer patients commonly develop infectious complications over the course of the disease. One thousand patients receiving treatment for an oncologic disease at a single veterinary teaching hospital were retrospectively reviewed for concurrent infections. A total of 153 confirmed bacterial infections were identified, 82 of which were abscesses or wounds, 13 of which were respiratory infections, 3 of which were ear infections, and 55 of which were urinary tract infections. It was observed that the majority of the infections were caused by bacteria that are normally associated with that specific site location. <i>Escherichia coli</i> was the most common pathogen linked to infections in general, but <i>Staphylococcus pseudintermedius</i> was a frequently identified pathogen associated with wound infections. The susceptibility to diverse antimicrobials varied with the site of infection. Eleven cases (7.1%) were caused by opportunistic infections of the site, and <i>E. coli</i> and <i>Pseudomonas aeruginosa</i> were the pathogens isolated. Those bacteria were resistant to many antibiotics but showed susceptibility to aminoglycosides, imipenem, quinolones, and polymyxin B. In conclusion, veterinary patients with cancer or those under treatment for tumors develop infections by commonly encountered bacteria in the different sites of the body, with a susceptibility to antibiotics that is not out of line from what is expected. A small subset of cases developed opportunistic infections, with microbes that were more resistant to many classes of antibiotics.https://www.mdpi.com/2079-6382/10/6/700antibioticsinfectionpatientscancertreatmentempiric |
| spellingShingle | Katie Curran Haley Leeper Kathy O’Reilly Joelle Jacob Luiz E. Bermudez An Analysis of the Infections and Determination of Empiric Antibiotic Therapy in Cats and Dogs with Cancer-Associated Infections Antibiotics antibiotics infection patients cancer treatment empiric |
| title | An Analysis of the Infections and Determination of Empiric Antibiotic Therapy in Cats and Dogs with Cancer-Associated Infections |
| title_full | An Analysis of the Infections and Determination of Empiric Antibiotic Therapy in Cats and Dogs with Cancer-Associated Infections |
| title_fullStr | An Analysis of the Infections and Determination of Empiric Antibiotic Therapy in Cats and Dogs with Cancer-Associated Infections |
| title_full_unstemmed | An Analysis of the Infections and Determination of Empiric Antibiotic Therapy in Cats and Dogs with Cancer-Associated Infections |
| title_short | An Analysis of the Infections and Determination of Empiric Antibiotic Therapy in Cats and Dogs with Cancer-Associated Infections |
| title_sort | analysis of the infections and determination of empiric antibiotic therapy in cats and dogs with cancer associated infections |
| topic | antibiotics infection patients cancer treatment empiric |
| url | https://www.mdpi.com/2079-6382/10/6/700 |
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