The effect of opioid receptor blockade on the neural processing of thermal stimuli.
The endogenous opioid system represents one of the principal systems in the modulation of pain. This has been demonstrated in studies of placebo analgesia and stress-induced analgesia, where anti-nociceptive activity triggered by pain itself or by cognitive states is blocked by opioid antagonists. T...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2010-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2930255?pdf=render |
| _version_ | 1811286475882364928 |
|---|---|
| author | Eszter D Schoell Ulrike Bingel Falk Eippert Juliana Yacubian Kerrin Christiansen Hilke Andresen Arne May Christian Buechel |
| author_facet | Eszter D Schoell Ulrike Bingel Falk Eippert Juliana Yacubian Kerrin Christiansen Hilke Andresen Arne May Christian Buechel |
| author_sort | Eszter D Schoell |
| collection | DOAJ |
| description | The endogenous opioid system represents one of the principal systems in the modulation of pain. This has been demonstrated in studies of placebo analgesia and stress-induced analgesia, where anti-nociceptive activity triggered by pain itself or by cognitive states is blocked by opioid antagonists. The aim of this study was to characterize the effect of opioid receptor blockade on the physiological processing of painful thermal stimulation in the absence of cognitive manipulation. We therefore measured BOLD (blood oxygen level dependent) signal responses and intensity ratings to non-painful and painful thermal stimuli in a double-blind, cross-over design using the opioid receptor antagonist naloxone. On the behavioral level, we observed an increase in intensity ratings under naloxone due mainly to a difference in the non-painful stimuli. On the neural level, painful thermal stimulation was associated with a negative BOLD signal within the pregenual anterior cingulate cortex, and this deactivation was abolished by naloxone. |
| first_indexed | 2024-04-13T03:00:34Z |
| format | Article |
| id | doaj.art-0d4c6b1c98f640a1a90ba7e38a481f77 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T03:00:34Z |
| publishDate | 2010-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0d4c6b1c98f640a1a90ba7e38a481f772022-12-22T03:05:26ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-01-0158e1234410.1371/journal.pone.0012344The effect of opioid receptor blockade on the neural processing of thermal stimuli.Eszter D SchoellUlrike BingelFalk EippertJuliana YacubianKerrin ChristiansenHilke AndresenArne MayChristian BuechelThe endogenous opioid system represents one of the principal systems in the modulation of pain. This has been demonstrated in studies of placebo analgesia and stress-induced analgesia, where anti-nociceptive activity triggered by pain itself or by cognitive states is blocked by opioid antagonists. The aim of this study was to characterize the effect of opioid receptor blockade on the physiological processing of painful thermal stimulation in the absence of cognitive manipulation. We therefore measured BOLD (blood oxygen level dependent) signal responses and intensity ratings to non-painful and painful thermal stimuli in a double-blind, cross-over design using the opioid receptor antagonist naloxone. On the behavioral level, we observed an increase in intensity ratings under naloxone due mainly to a difference in the non-painful stimuli. On the neural level, painful thermal stimulation was associated with a negative BOLD signal within the pregenual anterior cingulate cortex, and this deactivation was abolished by naloxone.http://europepmc.org/articles/PMC2930255?pdf=render |
| spellingShingle | Eszter D Schoell Ulrike Bingel Falk Eippert Juliana Yacubian Kerrin Christiansen Hilke Andresen Arne May Christian Buechel The effect of opioid receptor blockade on the neural processing of thermal stimuli. PLoS ONE |
| title | The effect of opioid receptor blockade on the neural processing of thermal stimuli. |
| title_full | The effect of opioid receptor blockade on the neural processing of thermal stimuli. |
| title_fullStr | The effect of opioid receptor blockade on the neural processing of thermal stimuli. |
| title_full_unstemmed | The effect of opioid receptor blockade on the neural processing of thermal stimuli. |
| title_short | The effect of opioid receptor blockade on the neural processing of thermal stimuli. |
| title_sort | effect of opioid receptor blockade on the neural processing of thermal stimuli |
| url | http://europepmc.org/articles/PMC2930255?pdf=render |
| work_keys_str_mv | AT eszterdschoell theeffectofopioidreceptorblockadeontheneuralprocessingofthermalstimuli AT ulrikebingel theeffectofopioidreceptorblockadeontheneuralprocessingofthermalstimuli AT falkeippert theeffectofopioidreceptorblockadeontheneuralprocessingofthermalstimuli AT julianayacubian theeffectofopioidreceptorblockadeontheneuralprocessingofthermalstimuli AT kerrinchristiansen theeffectofopioidreceptorblockadeontheneuralprocessingofthermalstimuli AT hilkeandresen theeffectofopioidreceptorblockadeontheneuralprocessingofthermalstimuli AT arnemay theeffectofopioidreceptorblockadeontheneuralprocessingofthermalstimuli AT christianbuechel theeffectofopioidreceptorblockadeontheneuralprocessingofthermalstimuli AT eszterdschoell effectofopioidreceptorblockadeontheneuralprocessingofthermalstimuli AT ulrikebingel effectofopioidreceptorblockadeontheneuralprocessingofthermalstimuli AT falkeippert effectofopioidreceptorblockadeontheneuralprocessingofthermalstimuli AT julianayacubian effectofopioidreceptorblockadeontheneuralprocessingofthermalstimuli AT kerrinchristiansen effectofopioidreceptorblockadeontheneuralprocessingofthermalstimuli AT hilkeandresen effectofopioidreceptorblockadeontheneuralprocessingofthermalstimuli AT arnemay effectofopioidreceptorblockadeontheneuralprocessingofthermalstimuli AT christianbuechel effectofopioidreceptorblockadeontheneuralprocessingofthermalstimuli |