Ferroptosis and its Role in Gastric Cancer
Gastric cancer (GC) is the fifth most common cancer and the third leading cause of cancer-related deaths worldwide. Currently, surgery is the treatment of choice for GC. However, the associated expenses and post-surgical pain impose a huge burden on these patients. Furthermore, disease recurrence is...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.860344/full |
| _version_ | 1811330000621666304 |
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| author | Renjun Gu Renjun Gu Yawen Xia Yawen Xia Pengfei Li Defang Zou Defang Zou Keqin Lu Keqin Lu Lang Ren Lang Ren Hongru Zhang Zhiguang Sun Zhiguang Sun |
| author_facet | Renjun Gu Renjun Gu Yawen Xia Yawen Xia Pengfei Li Defang Zou Defang Zou Keqin Lu Keqin Lu Lang Ren Lang Ren Hongru Zhang Zhiguang Sun Zhiguang Sun |
| author_sort | Renjun Gu |
| collection | DOAJ |
| description | Gastric cancer (GC) is the fifth most common cancer and the third leading cause of cancer-related deaths worldwide. Currently, surgery is the treatment of choice for GC. However, the associated expenses and post-surgical pain impose a huge burden on these patients. Furthermore, disease recurrence is also very common in GC patients, thus necessitating the discovery and development of other potential treatment options. A growing body of knowledge about ferroptosis in different cancer types provides a new perspective in cancer therapeutics. Ferroptosis is an iron-dependent form of cell death. It is characterized by intracellular lipid peroxide accumulation and redox imbalance. In this review, we summarized the current findings of ferroptosis regulation in GC. We also tackled on the action of different potential drugs and genes in inducing ferroptosis for treating GC and solving drug resistance. Furthermore, we also explored the relationship between ferroptosis and the tumor microenvironment in GC. Finally, we discussed areas for future studies on the role of ferroptosis in GC to accelerate the clinical utility of ferroptosis induction as a treatment strategy for GC. |
| first_indexed | 2024-04-13T15:53:44Z |
| format | Article |
| id | doaj.art-0d4cf3dea96642b481d6885bc119d34f |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-13T15:53:44Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-0d4cf3dea96642b481d6885bc119d34f2022-12-22T02:40:45ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-06-011010.3389/fcell.2022.860344860344Ferroptosis and its Role in Gastric CancerRenjun Gu0Renjun Gu1Yawen Xia2Yawen Xia3Pengfei Li4Defang Zou5Defang Zou6Keqin Lu7Keqin Lu8Lang Ren9Lang Ren10Hongru Zhang11Zhiguang Sun12Zhiguang Sun13Nanjing University of Chinese Medicine, Nanjing, ChinaJiangsu Provincial Second Chinese Medicine Hospital, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaJiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, ChinaJiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Clinical Laboratory, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaJiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, ChinaJiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing, ChinaJiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, ChinaJiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing, ChinaNanjing University of Chinese Medicine, Nanjing, ChinaJiangsu Provincial Second Chinese Medicine Hospital, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaSchool of Basic Medical Sciences, Nanjing University of Chinese Medicine, Nanjing, ChinaNanjing University of Chinese Medicine, Nanjing, ChinaJiangsu Provincial Second Chinese Medicine Hospital, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaGastric cancer (GC) is the fifth most common cancer and the third leading cause of cancer-related deaths worldwide. Currently, surgery is the treatment of choice for GC. However, the associated expenses and post-surgical pain impose a huge burden on these patients. Furthermore, disease recurrence is also very common in GC patients, thus necessitating the discovery and development of other potential treatment options. A growing body of knowledge about ferroptosis in different cancer types provides a new perspective in cancer therapeutics. Ferroptosis is an iron-dependent form of cell death. It is characterized by intracellular lipid peroxide accumulation and redox imbalance. In this review, we summarized the current findings of ferroptosis regulation in GC. We also tackled on the action of different potential drugs and genes in inducing ferroptosis for treating GC and solving drug resistance. Furthermore, we also explored the relationship between ferroptosis and the tumor microenvironment in GC. Finally, we discussed areas for future studies on the role of ferroptosis in GC to accelerate the clinical utility of ferroptosis induction as a treatment strategy for GC.https://www.frontiersin.org/articles/10.3389/fcell.2022.860344/fullferroptosisirongastric cancerROSmicroenvironmentdrug resistance |
| spellingShingle | Renjun Gu Renjun Gu Yawen Xia Yawen Xia Pengfei Li Defang Zou Defang Zou Keqin Lu Keqin Lu Lang Ren Lang Ren Hongru Zhang Zhiguang Sun Zhiguang Sun Ferroptosis and its Role in Gastric Cancer Frontiers in Cell and Developmental Biology ferroptosis iron gastric cancer ROS microenvironment drug resistance |
| title | Ferroptosis and its Role in Gastric Cancer |
| title_full | Ferroptosis and its Role in Gastric Cancer |
| title_fullStr | Ferroptosis and its Role in Gastric Cancer |
| title_full_unstemmed | Ferroptosis and its Role in Gastric Cancer |
| title_short | Ferroptosis and its Role in Gastric Cancer |
| title_sort | ferroptosis and its role in gastric cancer |
| topic | ferroptosis iron gastric cancer ROS microenvironment drug resistance |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.860344/full |
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