Research Progress of Epithelial-mesenchymal Transition Treatment and Drug Resistance in Colorectal Cancer
Colorectal cancer (CRC) is one of the most common malignancies in the world that seriously affects human health. Activation of epithelial-mesenchymal transition (EMT) is a physiological phenomenon during embryonic development that is essential for cell metastasis. EMT participates in various biologi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-04-01
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| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/15330338221081219 |
| _version_ | 1828275348017512448 |
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| author | Qianyang Ni MD Meng Li PhD Suyang Yu PhD |
| author_facet | Qianyang Ni MD Meng Li PhD Suyang Yu PhD |
| author_sort | Qianyang Ni MD |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is one of the most common malignancies in the world that seriously affects human health. Activation of epithelial-mesenchymal transition (EMT) is a physiological phenomenon during embryonic development that is essential for cell metastasis. EMT participates in various biological processes associated with trauma repair, organ fibrosis, migration, metastasis, and infiltration of tumor cells. EMT is a new therapeutic target for CRC; however, some patients with CRC develop resistance to some drugs due to EMT. This review focuses specifically on the status of treatments that target the EMT process and its role in the therapeutic resistance observed in patients with CRC. |
| first_indexed | 2024-04-13T06:47:13Z |
| format | Article |
| id | doaj.art-0d4e6dc4c745453cb7e07eba3a05650e |
| institution | Directory Open Access Journal |
| issn | 1533-0338 |
| language | English |
| last_indexed | 2024-04-13T06:47:13Z |
| publishDate | 2022-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj.art-0d4e6dc4c745453cb7e07eba3a05650e2022-12-22T02:57:32ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382022-04-012110.1177/15330338221081219Research Progress of Epithelial-mesenchymal Transition Treatment and Drug Resistance in Colorectal CancerQianyang Ni MD0Meng Li PhD1Suyang Yu PhD2 Department of Gastrointestinal Surgery, , Shijiazhuang, China Meng Li has become the co-first author due to his outstanding contribution Department of Gastrointestinal Surgery, , Shijiazhuang, China Colorectal cancer (CRC) is one of the most common malignancies in the world that seriously affects human health. Activation of epithelial-mesenchymal transition (EMT) is a physiological phenomenon during embryonic development that is essential for cell metastasis. EMT participates in various biological processes associated with trauma repair, organ fibrosis, migration, metastasis, and infiltration of tumor cells. EMT is a new therapeutic target for CRC; however, some patients with CRC develop resistance to some drugs due to EMT. This review focuses specifically on the status of treatments that target the EMT process and its role in the therapeutic resistance observed in patients with CRC.https://doi.org/10.1177/15330338221081219 |
| spellingShingle | Qianyang Ni MD Meng Li PhD Suyang Yu PhD Research Progress of Epithelial-mesenchymal Transition Treatment and Drug Resistance in Colorectal Cancer Technology in Cancer Research & Treatment |
| title | Research Progress of Epithelial-mesenchymal Transition Treatment and Drug Resistance in Colorectal Cancer |
| title_full | Research Progress of Epithelial-mesenchymal Transition Treatment and Drug Resistance in Colorectal Cancer |
| title_fullStr | Research Progress of Epithelial-mesenchymal Transition Treatment and Drug Resistance in Colorectal Cancer |
| title_full_unstemmed | Research Progress of Epithelial-mesenchymal Transition Treatment and Drug Resistance in Colorectal Cancer |
| title_short | Research Progress of Epithelial-mesenchymal Transition Treatment and Drug Resistance in Colorectal Cancer |
| title_sort | research progress of epithelial mesenchymal transition treatment and drug resistance in colorectal cancer |
| url | https://doi.org/10.1177/15330338221081219 |
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