<b>Development and validation of analytical methodology for quantification of propranolol hydrochloride in a multiparticulate biphasic system by UV-vis spectrophotometry
Hypertension is one of the most important mortality risks in the world and is considered the leading cause of deaths associated with cardiovascular disease. In an attempt to improve the treatments and apply them to a large number of disorders, a propranolol hydrochloride (Prop) based medicine it was...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Universidade Estadual de Maringá
2018-01-01
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| Series: | Acta Scientiarum: Technology |
| Subjects: | |
| Online Access: | http://periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/30754 |
| _version_ | 1818568128351698944 |
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| author | Sarah Moherdaui Martins Mauricio Ferreira da Rosa Fábio Souza Vanderson Galan Vinícius Muller Itamar Francisco Andreazza |
| author_facet | Sarah Moherdaui Martins Mauricio Ferreira da Rosa Fábio Souza Vanderson Galan Vinícius Muller Itamar Francisco Andreazza |
| author_sort | Sarah Moherdaui Martins |
| collection | DOAJ |
| description | Hypertension is one of the most important mortality risks in the world and is considered the leading cause of deaths associated with cardiovascular disease. In an attempt to improve the treatments and apply them to a large number of disorders, a propranolol hydrochloride (Prop) based medicine it was developed in our laboratory, employing a multiparticulate system which operates in a biphasic manner, one portion of immediate and other of modified release. This study aimed at developing and validating a suitable method to quantify this new version of the drug using UV spectrophotometry, following what is recommended in RE 899/2003. The results showed that the method employed was linear, accurate, precise and robust in the range of 0.8 to 96.0 μg mL-1, which allows it for routine use in quality control laboratories. |
| first_indexed | 2024-12-14T06:32:01Z |
| format | Article |
| id | doaj.art-0d4f23f66be94156a2af0176576e5f40 |
| institution | Directory Open Access Journal |
| issn | 1807-8664 |
| language | English |
| last_indexed | 2024-12-14T06:32:01Z |
| publishDate | 2018-01-01 |
| publisher | Universidade Estadual de Maringá |
| record_format | Article |
| series | Acta Scientiarum: Technology |
| spelling | doaj.art-0d4f23f66be94156a2af0176576e5f402022-12-21T23:13:29ZengUniversidade Estadual de MaringáActa Scientiarum: Technology1807-86642018-01-01401e30754e3075410.4025/actascitechnol.v40i1.3075417456<b>Development and validation of analytical methodology for quantification of propranolol hydrochloride in a multiparticulate biphasic system by UV-vis spectrophotometrySarah Moherdaui Martins0Mauricio Ferreira da Rosa1Fábio Souza2Vanderson Galan3Vinícius Muller4Itamar Francisco Andreazza5EMS Indústria FarmacêuticaUniversidade Estadual do Oeste do ParanáPrati, Donaduzzi & Cia Ltda. Medicamentos GenéricosPrati, Donaduzzi & Cia Ltda. Medicamentos GenéricosPrati, Donaduzzi & Cia Ltda. Medicamentos GenéricosUniversidade Federal do ParanáHypertension is one of the most important mortality risks in the world and is considered the leading cause of deaths associated with cardiovascular disease. In an attempt to improve the treatments and apply them to a large number of disorders, a propranolol hydrochloride (Prop) based medicine it was developed in our laboratory, employing a multiparticulate system which operates in a biphasic manner, one portion of immediate and other of modified release. This study aimed at developing and validating a suitable method to quantify this new version of the drug using UV spectrophotometry, following what is recommended in RE 899/2003. The results showed that the method employed was linear, accurate, precise and robust in the range of 0.8 to 96.0 μg mL-1, which allows it for routine use in quality control laboratories.http://periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/30754biphasic releasemultiparticulate systempellets. |
| spellingShingle | Sarah Moherdaui Martins Mauricio Ferreira da Rosa Fábio Souza Vanderson Galan Vinícius Muller Itamar Francisco Andreazza <b>Development and validation of analytical methodology for quantification of propranolol hydrochloride in a multiparticulate biphasic system by UV-vis spectrophotometry Acta Scientiarum: Technology biphasic release multiparticulate system pellets. |
| title | <b>Development and validation of analytical methodology for quantification of propranolol hydrochloride in a multiparticulate biphasic system by UV-vis spectrophotometry |
| title_full | <b>Development and validation of analytical methodology for quantification of propranolol hydrochloride in a multiparticulate biphasic system by UV-vis spectrophotometry |
| title_fullStr | <b>Development and validation of analytical methodology for quantification of propranolol hydrochloride in a multiparticulate biphasic system by UV-vis spectrophotometry |
| title_full_unstemmed | <b>Development and validation of analytical methodology for quantification of propranolol hydrochloride in a multiparticulate biphasic system by UV-vis spectrophotometry |
| title_short | <b>Development and validation of analytical methodology for quantification of propranolol hydrochloride in a multiparticulate biphasic system by UV-vis spectrophotometry |
| title_sort | b development and validation of analytical methodology for quantification of propranolol hydrochloride in a multiparticulate biphasic system by uv vis spectrophotometry |
| topic | biphasic release multiparticulate system pellets. |
| url | http://periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/30754 |
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