Predictive Value of Free Triiodothyronine in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention
Background: Homeostasis of thyroid hormones has significant effects on the cardiovascular system. The aim of this study was to investigate the association between free triiodothyronine (FT3) and adverse cardiovascular events in patients with acute coronary syndrome (ACS) who were undergoing percutan...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2022-06-01
|
| Series: | Reviews in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/RCM/23/7/10.31083/j.rcm2307230 |
| _version_ | 1818465735637204992 |
|---|---|
| author | Zhi Qiang Yang Xiao Teng Ma Qiao Yu Shao Qiu Xuan Li Yu Fei Wang Jing Liang Hua Shen Xiao Li Liu Dong Mei Shi Yu Jie Zhou Zhe Fang Zhi Jian Wang |
| author_facet | Zhi Qiang Yang Xiao Teng Ma Qiao Yu Shao Qiu Xuan Li Yu Fei Wang Jing Liang Hua Shen Xiao Li Liu Dong Mei Shi Yu Jie Zhou Zhe Fang Zhi Jian Wang |
| author_sort | Zhi Qiang Yang |
| collection | DOAJ |
| description | Background: Homeostasis of thyroid hormones has significant effects on the cardiovascular system. The aim of this study was to investigate the association between free triiodothyronine (FT3) and adverse cardiovascular events in patients with acute coronary syndrome (ACS) who were undergoing percutaneous coronary intervention (PCI). Methods: A total of 1701 patients with ACS undergoing PCI were included in this study. All patients were divided into three groups according to the tertiles of FT3 level: the lowest tertile (FT3 <4.51 pmol/L), the middle tertile (4.51 pmol/L ≤ FT3 < 4.89 pmol/L) and the highest tertile group (FT3 ≥4.89 pmol/L). The primary study endpoint was a composite of major adverse cardiovascular events (MACE), which included all-cause death, ischemic stroke, myocardial infarction, or unplanned repeat revascularization. Results: During a median follow-up period of 927 days, 349 patients had at least one event. Compared with patients with the highest tertile, those with the lowest tertile had a significantly higher incidence of MACE, all-cause death, MI, ischemic stroke and repeat revascularization (all p values < 0.05). In the multivariate Cox regression analysis, the middle tertile had similar risk of MACE (HR = 0.986, 95% CI 0.728–1.336, p = 0.929) as the highest tertile, but the patients with the lowest tertile had a 92.9% higher risk of MACE (HR = 1.929, 95% CI 1.467–2.535, p < 0.001). There was a non-linear relationship between FT3 and MACE and unplanned repeat revascularization (all p values for non-linear association <0.001). Adding the tertiles of FT3 level into the baseline model yielded a significant improvement in discrimination for predicting MACE (ΔAUC = 0.013, p = 0.025). Conclusions: A significantly reduced FT3 level was independently associated with a worse prognosis in patients with ACS undergoing PCI. |
| first_indexed | 2024-04-13T20:48:40Z |
| format | Article |
| id | doaj.art-0d500c66088641a481d7ac4dd80387f2 |
| institution | Directory Open Access Journal |
| issn | 1530-6550 |
| language | English |
| last_indexed | 2024-04-13T20:48:40Z |
| publishDate | 2022-06-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj.art-0d500c66088641a481d7ac4dd80387f22022-12-22T02:30:35ZengIMR PressReviews in Cardiovascular Medicine1530-65502022-06-0123723010.31083/j.rcm2307230S1530-6550(22)00602-0Predictive Value of Free Triiodothyronine in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary InterventionZhi Qiang Yang0Xiao Teng Ma1Qiao Yu Shao2Qiu Xuan Li3Yu Fei Wang4Jing Liang5Hua Shen6Xiao Li Liu7Dong Mei Shi8Yu Jie Zhou9Zhe Fang10Zhi Jian Wang11Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical Center for Coronary Heart Disease, Capital Medical University, 100029 Beijing, ChinaDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical Center for Coronary Heart Disease, Capital Medical University, 100029 Beijing, ChinaDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical Center for Coronary Heart Disease, Capital Medical University, 100029 Beijing, ChinaDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical Center for Coronary Heart Disease, Capital Medical University, 100029 Beijing, ChinaDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical Center for Coronary Heart Disease, Capital Medical University, 100029 Beijing, ChinaDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical Center for Coronary Heart Disease, Capital Medical University, 100029 Beijing, ChinaDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical Center for Coronary Heart Disease, Capital Medical University, 100029 Beijing, ChinaDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical Center for Coronary Heart Disease, Capital Medical University, 100029 Beijing, ChinaDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical Center for Coronary Heart Disease, Capital Medical University, 100029 Beijing, ChinaDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical Center for Coronary Heart Disease, Capital Medical University, 100029 Beijing, ChinaDepartment of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, 330006 Nanchang, Jiangxi, ChinaDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical Center for Coronary Heart Disease, Capital Medical University, 100029 Beijing, ChinaBackground: Homeostasis of thyroid hormones has significant effects on the cardiovascular system. The aim of this study was to investigate the association between free triiodothyronine (FT3) and adverse cardiovascular events in patients with acute coronary syndrome (ACS) who were undergoing percutaneous coronary intervention (PCI). Methods: A total of 1701 patients with ACS undergoing PCI were included in this study. All patients were divided into three groups according to the tertiles of FT3 level: the lowest tertile (FT3 <4.51 pmol/L), the middle tertile (4.51 pmol/L ≤ FT3 < 4.89 pmol/L) and the highest tertile group (FT3 ≥4.89 pmol/L). The primary study endpoint was a composite of major adverse cardiovascular events (MACE), which included all-cause death, ischemic stroke, myocardial infarction, or unplanned repeat revascularization. Results: During a median follow-up period of 927 days, 349 patients had at least one event. Compared with patients with the highest tertile, those with the lowest tertile had a significantly higher incidence of MACE, all-cause death, MI, ischemic stroke and repeat revascularization (all p values < 0.05). In the multivariate Cox regression analysis, the middle tertile had similar risk of MACE (HR = 0.986, 95% CI 0.728–1.336, p = 0.929) as the highest tertile, but the patients with the lowest tertile had a 92.9% higher risk of MACE (HR = 1.929, 95% CI 1.467–2.535, p < 0.001). There was a non-linear relationship between FT3 and MACE and unplanned repeat revascularization (all p values for non-linear association <0.001). Adding the tertiles of FT3 level into the baseline model yielded a significant improvement in discrimination for predicting MACE (ΔAUC = 0.013, p = 0.025). Conclusions: A significantly reduced FT3 level was independently associated with a worse prognosis in patients with ACS undergoing PCI.https://www.imrpress.com/journal/RCM/23/7/10.31083/j.rcm2307230free triiodothyronineacute coronary syndromepercutaneous coronary interventionadverse cardiovascular events |
| spellingShingle | Zhi Qiang Yang Xiao Teng Ma Qiao Yu Shao Qiu Xuan Li Yu Fei Wang Jing Liang Hua Shen Xiao Li Liu Dong Mei Shi Yu Jie Zhou Zhe Fang Zhi Jian Wang Predictive Value of Free Triiodothyronine in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention Reviews in Cardiovascular Medicine free triiodothyronine acute coronary syndrome percutaneous coronary intervention adverse cardiovascular events |
| title | Predictive Value of Free Triiodothyronine in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention |
| title_full | Predictive Value of Free Triiodothyronine in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention |
| title_fullStr | Predictive Value of Free Triiodothyronine in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention |
| title_full_unstemmed | Predictive Value of Free Triiodothyronine in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention |
| title_short | Predictive Value of Free Triiodothyronine in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention |
| title_sort | predictive value of free triiodothyronine in patients with acute coronary syndrome undergoing percutaneous coronary intervention |
| topic | free triiodothyronine acute coronary syndrome percutaneous coronary intervention adverse cardiovascular events |
| url | https://www.imrpress.com/journal/RCM/23/7/10.31083/j.rcm2307230 |
| work_keys_str_mv | AT zhiqiangyang predictivevalueoffreetriiodothyronineinpatientswithacutecoronarysyndromeundergoingpercutaneouscoronaryintervention AT xiaotengma predictivevalueoffreetriiodothyronineinpatientswithacutecoronarysyndromeundergoingpercutaneouscoronaryintervention AT qiaoyushao predictivevalueoffreetriiodothyronineinpatientswithacutecoronarysyndromeundergoingpercutaneouscoronaryintervention AT qiuxuanli predictivevalueoffreetriiodothyronineinpatientswithacutecoronarysyndromeundergoingpercutaneouscoronaryintervention AT yufeiwang predictivevalueoffreetriiodothyronineinpatientswithacutecoronarysyndromeundergoingpercutaneouscoronaryintervention AT jingliang predictivevalueoffreetriiodothyronineinpatientswithacutecoronarysyndromeundergoingpercutaneouscoronaryintervention AT huashen predictivevalueoffreetriiodothyronineinpatientswithacutecoronarysyndromeundergoingpercutaneouscoronaryintervention AT xiaoliliu predictivevalueoffreetriiodothyronineinpatientswithacutecoronarysyndromeundergoingpercutaneouscoronaryintervention AT dongmeishi predictivevalueoffreetriiodothyronineinpatientswithacutecoronarysyndromeundergoingpercutaneouscoronaryintervention AT yujiezhou predictivevalueoffreetriiodothyronineinpatientswithacutecoronarysyndromeundergoingpercutaneouscoronaryintervention AT zhefang predictivevalueoffreetriiodothyronineinpatientswithacutecoronarysyndromeundergoingpercutaneouscoronaryintervention AT zhijianwang predictivevalueoffreetriiodothyronineinpatientswithacutecoronarysyndromeundergoingpercutaneouscoronaryintervention |