Co (II) Complexes Based on the <i>Bis</i>-Pyrazol<i>-S</i>-Triazine Pincer Ligand: Synthesis, X-ray Structure Studies, and Cytotoxic Evaluation
Four pincer-type Co (II) complexes of the 2,4-<i>bis</i> (3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-6-methoxy-1,3,5-triazine ligand (<b>L</b>) were evaluated for their cytotoxic activities against lung and breast cancer cell lines using cell viability assay. The X-ray...
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MDPI AG
2022-05-01
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| author | Heba M. Refaat Atallh A. M. Alotaibi Necmi Dege Ayman El-Faham Saied M. Soliman |
| author_facet | Heba M. Refaat Atallh A. M. Alotaibi Necmi Dege Ayman El-Faham Saied M. Soliman |
| author_sort | Heba M. Refaat |
| collection | DOAJ |
| description | Four pincer-type Co (II) complexes of the 2,4-<i>bis</i> (3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-6-methoxy-1,3,5-triazine ligand (<b>L</b>) were evaluated for their cytotoxic activities against lung and breast cancer cell lines using cell viability assay. The X-ray single crystal structure of [Co(L)(H<sub>2</sub>O)<sub>2</sub>Br]Br (<b>1</b>) confirmed the pincer coordination behavior of the ligand <b>L</b> as an <i>N</i>-tridentate chelate. The hexa-coordination environment of Co (II) is completed by one bromide ion completing the equatorial plane of the octahedral structure and two <i>trans</i> water molecules at the axial positions. It crystallized in the monoclinic crystal system and <i>P2<sub>1</sub>/m</i> space group with crystal parameters of a = 11.3170(10) Å, b = 7.4613(7) Å, c = 12.6917(12) Å and β = 95.927(3)°. Based on Hirshfeld analysis, the most dominant contacts are H…H (48.8%), Br…H (17.6%), H…C (11.2%) and O…H (10.1%), where the Br…H interactions are the most significant. The cytotoxic evaluation of the studied systems indicated that complex [Co(L)(NO<sub>3</sub>)<sub>2</sub>] (<b>4</b>) has the highest activity against lung (A-549) and breast (MCF-7) cell lines. In contrast, complex [Co(L)(H<sub>2</sub>O)<sub>3</sub>](ClO<sub>4</sub>)<sub>2</sub>.H<sub>2</sub>O(<b>3</b>) has the lowest cytotoxic activity against both cell lines. |
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| issn | 2073-4352 |
| language | English |
| last_indexed | 2024-03-10T03:04:27Z |
| publishDate | 2022-05-01 |
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| spelling | doaj.art-0d5100f791964b6196e660a84d275db12023-11-23T10:36:21ZengMDPI AGCrystals2073-43522022-05-0112574110.3390/cryst12050741Co (II) Complexes Based on the <i>Bis</i>-Pyrazol<i>-S</i>-Triazine Pincer Ligand: Synthesis, X-ray Structure Studies, and Cytotoxic EvaluationHeba M. Refaat0Atallh A. M. Alotaibi1Necmi Dege2Ayman El-Faham3Saied M. Soliman4Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, EgyptDepartment of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, EgyptDepartment of Physics, Faculty of Arts and Sciences, Ondokuz Mayıs University, Samsun 55139, TurkeyDepartment of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, EgyptDepartment of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, EgyptFour pincer-type Co (II) complexes of the 2,4-<i>bis</i> (3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-6-methoxy-1,3,5-triazine ligand (<b>L</b>) were evaluated for their cytotoxic activities against lung and breast cancer cell lines using cell viability assay. The X-ray single crystal structure of [Co(L)(H<sub>2</sub>O)<sub>2</sub>Br]Br (<b>1</b>) confirmed the pincer coordination behavior of the ligand <b>L</b> as an <i>N</i>-tridentate chelate. The hexa-coordination environment of Co (II) is completed by one bromide ion completing the equatorial plane of the octahedral structure and two <i>trans</i> water molecules at the axial positions. It crystallized in the monoclinic crystal system and <i>P2<sub>1</sub>/m</i> space group with crystal parameters of a = 11.3170(10) Å, b = 7.4613(7) Å, c = 12.6917(12) Å and β = 95.927(3)°. Based on Hirshfeld analysis, the most dominant contacts are H…H (48.8%), Br…H (17.6%), H…C (11.2%) and O…H (10.1%), where the Br…H interactions are the most significant. The cytotoxic evaluation of the studied systems indicated that complex [Co(L)(NO<sub>3</sub>)<sub>2</sub>] (<b>4</b>) has the highest activity against lung (A-549) and breast (MCF-7) cell lines. In contrast, complex [Co(L)(H<sub>2</sub>O)<sub>3</sub>](ClO<sub>4</sub>)<sub>2</sub>.H<sub>2</sub>O(<b>3</b>) has the lowest cytotoxic activity against both cell lines.https://www.mdpi.com/2073-4352/12/5/741cobalt (II)pincer<i>bis</i>-pyrazol<i>-s</i>-triazineHirshfeldcytotoxicitybreast and lung carcinoma |
| spellingShingle | Heba M. Refaat Atallh A. M. Alotaibi Necmi Dege Ayman El-Faham Saied M. Soliman Co (II) Complexes Based on the <i>Bis</i>-Pyrazol<i>-S</i>-Triazine Pincer Ligand: Synthesis, X-ray Structure Studies, and Cytotoxic Evaluation Crystals cobalt (II) pincer <i>bis</i>-pyrazol<i>-s</i>-triazine Hirshfeld cytotoxicity breast and lung carcinoma |
| title | Co (II) Complexes Based on the <i>Bis</i>-Pyrazol<i>-S</i>-Triazine Pincer Ligand: Synthesis, X-ray Structure Studies, and Cytotoxic Evaluation |
| title_full | Co (II) Complexes Based on the <i>Bis</i>-Pyrazol<i>-S</i>-Triazine Pincer Ligand: Synthesis, X-ray Structure Studies, and Cytotoxic Evaluation |
| title_fullStr | Co (II) Complexes Based on the <i>Bis</i>-Pyrazol<i>-S</i>-Triazine Pincer Ligand: Synthesis, X-ray Structure Studies, and Cytotoxic Evaluation |
| title_full_unstemmed | Co (II) Complexes Based on the <i>Bis</i>-Pyrazol<i>-S</i>-Triazine Pincer Ligand: Synthesis, X-ray Structure Studies, and Cytotoxic Evaluation |
| title_short | Co (II) Complexes Based on the <i>Bis</i>-Pyrazol<i>-S</i>-Triazine Pincer Ligand: Synthesis, X-ray Structure Studies, and Cytotoxic Evaluation |
| title_sort | co ii complexes based on the i bis i pyrazol i s i triazine pincer ligand synthesis x ray structure studies and cytotoxic evaluation |
| topic | cobalt (II) pincer <i>bis</i>-pyrazol<i>-s</i>-triazine Hirshfeld cytotoxicity breast and lung carcinoma |
| url | https://www.mdpi.com/2073-4352/12/5/741 |
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