Surface electromyography to quantify neuro-respiratory drive and neuro-mechanical coupling in mechanically ventilated children
Abstract Background The patient’s neuro-respiratory drive, measured as electrical activity of the diaphragm (EAdi), quantifies the mechanical load on the respiratory muscles. It correlates with respiratory effort but requires a dedicated esophageal catheter. Transcutaneous (surface) monitoring of re...
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12931-023-02374-w |
| _version_ | 1797863782992576512 |
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| author | Alette A. Koopman Jefta van Dijk Eline Oppersma Robert G. T. Blokpoel Martin C. J. Kneyber |
| author_facet | Alette A. Koopman Jefta van Dijk Eline Oppersma Robert G. T. Blokpoel Martin C. J. Kneyber |
| author_sort | Alette A. Koopman |
| collection | DOAJ |
| description | Abstract Background The patient’s neuro-respiratory drive, measured as electrical activity of the diaphragm (EAdi), quantifies the mechanical load on the respiratory muscles. It correlates with respiratory effort but requires a dedicated esophageal catheter. Transcutaneous (surface) monitoring of respiratory muscle electromyographic (sEMG) signals may be considered a suitable alternative to EAdi because of its non-invasive character, with the additional benefit that it allows for simultaneously monitoring of other respiratory muscles. We therefore sought to study the neuro-respiratory drive and timing of inspiratory muscles using sEMG in a cohort of children enrolled in a pediatric ventilation liberation trial. The neuro-mechanical coupling, relating the pressure generated by the inspiratory muscles to the sEMG signals of these muscles, was also calculated. Methods This is a secondary analysis of data from a randomized cross-over trial in ventilated patients aged < 5 years. sEMG recordings of the diaphragm and parasternal intercostal muscles (ICM), esophageal pressure tracings and ventilator scalars were simultaneously recorded during continuous spontaneous ventilation and pressure controlled-intermittent mandatory ventilation, and at three levels of pressure support. Neuro-respiratory drive, timing of diaphragm and ICM relative to the mechanical ventilator’s inspiration and neuro-mechanical coupling were quantified. Results Twenty-nine patients were included (median age: 5.9 months). In response to decreasing pressure support, both amplitude of sEMG (diaphragm: p = 0.001 and ICM: p = 0.002) and neuro-mechanical efficiency indices increased (diaphragm: p = 0.05 and ICM: p < 0.001). Poor correlations between neuro-respiratory drive and respiratory effort were found, with R2: 0.088 [0.021–0.152]. Conclusions sEMG allows for the quantification of the electrical activity of the diaphragm and ICM in mechanically ventilated children. Both neuro-respiratory drive and neuro-mechanical efficiency increased in response to lower inspiratory assistance. There was poor correlation between neuro-respiratory drive and respiratory effort. Trial registration ClinicalTrials.gov ID NCT05254691. Registered 24 February 2022, registered retrospectively. |
| first_indexed | 2024-04-09T22:41:09Z |
| format | Article |
| id | doaj.art-0d512e20bc9948b0ae1c76bcd6674080 |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-04-09T22:41:09Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-0d512e20bc9948b0ae1c76bcd66740802023-03-22T12:07:57ZengBMCRespiratory Research1465-993X2023-03-0124111010.1186/s12931-023-02374-wSurface electromyography to quantify neuro-respiratory drive and neuro-mechanical coupling in mechanically ventilated childrenAlette A. Koopman0Jefta van Dijk1Eline Oppersma2Robert G. T. Blokpoel3Martin C. J. Kneyber4Division of Paediatric Critical Care Medicine, Department of Paediatrics, Beatrix Children’s Hospital, University Medical Center Groningen, University of GroningenDivision of Paediatric Critical Care Medicine, Department of Paediatrics, Beatrix Children’s Hospital, University Medical Center Groningen, University of GroningenCardiovascular and Respiratory Physiology Group, TechMed Centre, University of TwenteDivision of Paediatric Critical Care Medicine, Department of Paediatrics, Beatrix Children’s Hospital, University Medical Center Groningen, University of GroningenDivision of Paediatric Critical Care Medicine, Department of Paediatrics, Beatrix Children’s Hospital, University Medical Center Groningen, University of GroningenAbstract Background The patient’s neuro-respiratory drive, measured as electrical activity of the diaphragm (EAdi), quantifies the mechanical load on the respiratory muscles. It correlates with respiratory effort but requires a dedicated esophageal catheter. Transcutaneous (surface) monitoring of respiratory muscle electromyographic (sEMG) signals may be considered a suitable alternative to EAdi because of its non-invasive character, with the additional benefit that it allows for simultaneously monitoring of other respiratory muscles. We therefore sought to study the neuro-respiratory drive and timing of inspiratory muscles using sEMG in a cohort of children enrolled in a pediatric ventilation liberation trial. The neuro-mechanical coupling, relating the pressure generated by the inspiratory muscles to the sEMG signals of these muscles, was also calculated. Methods This is a secondary analysis of data from a randomized cross-over trial in ventilated patients aged < 5 years. sEMG recordings of the diaphragm and parasternal intercostal muscles (ICM), esophageal pressure tracings and ventilator scalars were simultaneously recorded during continuous spontaneous ventilation and pressure controlled-intermittent mandatory ventilation, and at three levels of pressure support. Neuro-respiratory drive, timing of diaphragm and ICM relative to the mechanical ventilator’s inspiration and neuro-mechanical coupling were quantified. Results Twenty-nine patients were included (median age: 5.9 months). In response to decreasing pressure support, both amplitude of sEMG (diaphragm: p = 0.001 and ICM: p = 0.002) and neuro-mechanical efficiency indices increased (diaphragm: p = 0.05 and ICM: p < 0.001). Poor correlations between neuro-respiratory drive and respiratory effort were found, with R2: 0.088 [0.021–0.152]. Conclusions sEMG allows for the quantification of the electrical activity of the diaphragm and ICM in mechanically ventilated children. Both neuro-respiratory drive and neuro-mechanical efficiency increased in response to lower inspiratory assistance. There was poor correlation between neuro-respiratory drive and respiratory effort. Trial registration ClinicalTrials.gov ID NCT05254691. Registered 24 February 2022, registered retrospectively.https://doi.org/10.1186/s12931-023-02374-wChildrenMechanical ventilationNeuro-respiratory driveNeuro-mechanical couplingSurface electromyographyPressure support |
| spellingShingle | Alette A. Koopman Jefta van Dijk Eline Oppersma Robert G. T. Blokpoel Martin C. J. Kneyber Surface electromyography to quantify neuro-respiratory drive and neuro-mechanical coupling in mechanically ventilated children Respiratory Research Children Mechanical ventilation Neuro-respiratory drive Neuro-mechanical coupling Surface electromyography Pressure support |
| title | Surface electromyography to quantify neuro-respiratory drive and neuro-mechanical coupling in mechanically ventilated children |
| title_full | Surface electromyography to quantify neuro-respiratory drive and neuro-mechanical coupling in mechanically ventilated children |
| title_fullStr | Surface electromyography to quantify neuro-respiratory drive and neuro-mechanical coupling in mechanically ventilated children |
| title_full_unstemmed | Surface electromyography to quantify neuro-respiratory drive and neuro-mechanical coupling in mechanically ventilated children |
| title_short | Surface electromyography to quantify neuro-respiratory drive and neuro-mechanical coupling in mechanically ventilated children |
| title_sort | surface electromyography to quantify neuro respiratory drive and neuro mechanical coupling in mechanically ventilated children |
| topic | Children Mechanical ventilation Neuro-respiratory drive Neuro-mechanical coupling Surface electromyography Pressure support |
| url | https://doi.org/10.1186/s12931-023-02374-w |
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