Role of the Rhamnosyl Residue of Ouabain in the Activation of the Na,K-ATPase Signaling Function

Role of the Rhamnosyl Residue of Ouabain in the Activation of the Na,K-ATPase Signaling Function

The signaling or non-pumping Na,K-ATPase function was first observed by us in the nociceptive neuron; Na,K-ATPase transduced the signals from the opioid-like receptors to Na<sub>V</sub>1.8 channels. This study elucidates the role of the rhamnosyl residue of ouabain in the activation of t...

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Main Authors: Ilya V. Rogachevskii, Dmitriy M. Samosvat, Valentina A. Penniyaynen, Vera B. Plakhova, Svetlana A. Podzorova, Ke Ma, Georgy G. Zegrya, Boris V. Krylov
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Life
Subjects:
ouabagenin
ouabain
rhamnosyl residue
Na,K-ATPase
Na<sub>V</sub>1.8 channel
patch-clamp method
Online Access:https://www.mdpi.com/2075-1729/13/7/1500

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