Serum miR-210 Contributes to Tumor Detection, Stage Prediction and Dynamic Surveillance in Patients with Bladder Cancer.
MiR-210 is the master hypoxamir that generally exhibits oncogenic properties in most human solid tumors including bladder cancer (BC). However, it remains unknown about the clinical significance of circulating miR-210 levels in BC. In this study, we found that serum miR-210 was up-regulated in patie...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4529273?pdf=render |
| _version_ | 1828407941704712192 |
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| author | Yongmei Yang Ailin Qu Jingkang Liu Rui Wang Yingjie Liu Gang Li Weili Duan Qian Fang Xiumei Jiang Lili Wang Guixi Zheng Lutao Du Xin Zhang Chuanxin Wang |
| author_facet | Yongmei Yang Ailin Qu Jingkang Liu Rui Wang Yingjie Liu Gang Li Weili Duan Qian Fang Xiumei Jiang Lili Wang Guixi Zheng Lutao Du Xin Zhang Chuanxin Wang |
| author_sort | Yongmei Yang |
| collection | DOAJ |
| description | MiR-210 is the master hypoxamir that generally exhibits oncogenic properties in most human solid tumors including bladder cancer (BC). However, it remains unknown about the clinical significance of circulating miR-210 levels in BC. In this study, we found that serum miR-210 was up-regulated in patients with BC, and serum levels of miR-210 increased with advancing stage and grade. Moreover, serum miR-210 expression was found to be significantly reduced in paired post-operative samples and elevated in most patients with relapsed BC. Taken together, our data suggest that serum miR-210 could be a potential noninvasive biomarker for screening, predicting and monitoring BC. |
| first_indexed | 2024-12-10T11:31:22Z |
| format | Article |
| id | doaj.art-0d554de206e24558a622fdc448e82605 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T11:31:22Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0d554de206e24558a622fdc448e826052022-12-22T01:50:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01108e013516810.1371/journal.pone.0135168Serum miR-210 Contributes to Tumor Detection, Stage Prediction and Dynamic Surveillance in Patients with Bladder Cancer.Yongmei YangAilin QuJingkang LiuRui WangYingjie LiuGang LiWeili DuanQian FangXiumei JiangLili WangGuixi ZhengLutao DuXin ZhangChuanxin WangMiR-210 is the master hypoxamir that generally exhibits oncogenic properties in most human solid tumors including bladder cancer (BC). However, it remains unknown about the clinical significance of circulating miR-210 levels in BC. In this study, we found that serum miR-210 was up-regulated in patients with BC, and serum levels of miR-210 increased with advancing stage and grade. Moreover, serum miR-210 expression was found to be significantly reduced in paired post-operative samples and elevated in most patients with relapsed BC. Taken together, our data suggest that serum miR-210 could be a potential noninvasive biomarker for screening, predicting and monitoring BC.http://europepmc.org/articles/PMC4529273?pdf=render |
| spellingShingle | Yongmei Yang Ailin Qu Jingkang Liu Rui Wang Yingjie Liu Gang Li Weili Duan Qian Fang Xiumei Jiang Lili Wang Guixi Zheng Lutao Du Xin Zhang Chuanxin Wang Serum miR-210 Contributes to Tumor Detection, Stage Prediction and Dynamic Surveillance in Patients with Bladder Cancer. PLoS ONE |
| title | Serum miR-210 Contributes to Tumor Detection, Stage Prediction and Dynamic Surveillance in Patients with Bladder Cancer. |
| title_full | Serum miR-210 Contributes to Tumor Detection, Stage Prediction and Dynamic Surveillance in Patients with Bladder Cancer. |
| title_fullStr | Serum miR-210 Contributes to Tumor Detection, Stage Prediction and Dynamic Surveillance in Patients with Bladder Cancer. |
| title_full_unstemmed | Serum miR-210 Contributes to Tumor Detection, Stage Prediction and Dynamic Surveillance in Patients with Bladder Cancer. |
| title_short | Serum miR-210 Contributes to Tumor Detection, Stage Prediction and Dynamic Surveillance in Patients with Bladder Cancer. |
| title_sort | serum mir 210 contributes to tumor detection stage prediction and dynamic surveillance in patients with bladder cancer |
| url | http://europepmc.org/articles/PMC4529273?pdf=render |
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