Elevated Neopterin Levels Predict Fatal Outcome in SARS-CoV-2-Infected Patients
HighlightsInnate immune activation during Covid-19 infection is associated with pernicious clinical outcome.BackgroundCoronavirus disease 2019 (Covid-19) is a worldwide threat that has already caused more than 3 000 000 deaths. It is characterized by different patterns of disease evolution depending...
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| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2021.709893/full |
| _version_ | 1819139837196763136 |
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| author | Manon Chauvin Martin Larsen Bibiana Quirant Bibiana Quirant Paul Quentric Karim Dorgham Luca Royer Hélène Vallet Hélène Vallet Amelie Guihot Amelie Guihot Béhazine Combadière Christophe Combadière Jaume Barallat Julien Mayaux Charles-Edouard Luyt Alexis Mathian Alexis Mathian Zahir Amoura Zahir Amoura Jacques Boddaert Jacques Boddaert Fernando Armestar Fernando Armestar Guy Gorochov Guy Gorochov Eva Martinez-Caceres Eva Martinez-Caceres Delphine Sauce |
| author_facet | Manon Chauvin Martin Larsen Bibiana Quirant Bibiana Quirant Paul Quentric Karim Dorgham Luca Royer Hélène Vallet Hélène Vallet Amelie Guihot Amelie Guihot Béhazine Combadière Christophe Combadière Jaume Barallat Julien Mayaux Charles-Edouard Luyt Alexis Mathian Alexis Mathian Zahir Amoura Zahir Amoura Jacques Boddaert Jacques Boddaert Fernando Armestar Fernando Armestar Guy Gorochov Guy Gorochov Eva Martinez-Caceres Eva Martinez-Caceres Delphine Sauce |
| author_sort | Manon Chauvin |
| collection | DOAJ |
| description | HighlightsInnate immune activation during Covid-19 infection is associated with pernicious clinical outcome.BackgroundCoronavirus disease 2019 (Covid-19) is a worldwide threat that has already caused more than 3 000 000 deaths. It is characterized by different patterns of disease evolution depending on host factors among which old-age and pre-existing comorbidities play a detrimental role. Previous coronavirus epidemics, notably SARS-CoV, were associated with increased serum neopterin levels, which can be interpreted as a sign of acute innate immunity in response to viral infection. Here we hypothesize that neopterin may serve as a biomarker of SARS-CoV-2 viral infection and Covid-19 disease severity.MethodsWe measured neopterin blood levels by ELISA. Seric concentration was quantified from 256 healthy donors and 374 Covid-19 patients at hospital admission. Enrolled Covid-19 patients were all symptomatic and displayed a large spectrum of comorbidities. Patients were followed until disease resolution or death.ResultsSevere and critically ill SARS-CoV-2 infected patients were characterized by a profound exacerbation of immune activation characterized by elevated neopterin blood levels. Systemic neopterin levels above 19nM stratified healthy individuals from Covid-19 patients with 87% specificity and 100% sensitivity. Moreover, systemic neopterin levels above 53nM differentiated non-survivors from survivors with 64% specificity and 100% sensitivity.ConclusionWe propose that neopterin concentration measured at arrival to hospital is a hallmark of severe Covid-19 and identifies a high-risk population of pernicious clinical outcome with a need for special medical care. |
| first_indexed | 2024-12-22T11:29:00Z |
| format | Article |
| id | doaj.art-0d56510dfa394fddb3e0d10f4d9e8ef4 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-22T11:29:00Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-0d56510dfa394fddb3e0d10f4d9e8ef42022-12-21T18:27:39ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882021-08-011110.3389/fcimb.2021.709893709893Elevated Neopterin Levels Predict Fatal Outcome in SARS-CoV-2-Infected PatientsManon Chauvin0Martin Larsen1Bibiana Quirant2Bibiana Quirant3Paul Quentric4Karim Dorgham5Luca Royer6Hélène Vallet7Hélène Vallet8Amelie Guihot9Amelie Guihot10Béhazine Combadière11Christophe Combadière12Jaume Barallat13Julien Mayaux14Charles-Edouard Luyt15Alexis Mathian16Alexis Mathian17Zahir Amoura18Zahir Amoura19Jacques Boddaert20Jacques Boddaert21Fernando Armestar22Fernando Armestar23Guy Gorochov24Guy Gorochov25Eva Martinez-Caceres26Eva Martinez-Caceres27Delphine Sauce28Sorbonne Université, Inserm, Centre d’Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, FranceSorbonne Université, Inserm, Centre d’Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, FranceDivision of Immunology, Germans Trias i Pujol University Hospital and Research Institute, Badalona, SpainDepartment of Cellular Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), SpainSorbonne Université, Inserm, Centre d’Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, FranceSorbonne Université, Inserm, Centre d’Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, FranceSorbonne Université, Inserm, Centre d’Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, FranceSorbonne Université, Inserm, Centre d’Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, FranceAssistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Antoine, Unité de Gériatrie Aigue, Paris, FranceSorbonne Université, Inserm, Centre d’Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, FranceAssistance Publique-Hôpitaux de Paris (AP-HP), Groupement Hospitalier Pitié-Salpêtrière, Département d’Immunologie, Paris, FranceSorbonne Université, Inserm, Centre d’Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, FranceSorbonne Université, Inserm, Centre d’Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, FranceBiochemistry Department, Germans Trias i Pujol University Hospital, Badalona, SpainAssistance Publique-Hôpitaux de Paris (AP-HP), Groupement Hospitalier Pitié-Salpêtrière, Service de Médecine Intensive–Réanimation et Pneumologie, Paris, FranceService de Médecine Intensive Réanimation, Institut de Cardiologie, Assistance Publique–Hôpitaux de Paris (APHP), Sorbonne-Université, Service de Médecine Intensive–Réanimation et Pneumologie, Paris, FranceSorbonne Université, Inserm, Centre d’Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, FranceService de Médecine Interne 2, Institut E3M, Assistance Publique Hôpitaux de Paris (AP-HP), Hôpital Pitié-Salpêtrière, Paris, FranceSorbonne Université, Inserm, Centre d’Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, FranceService de Médecine Interne 2, Institut E3M, Assistance Publique Hôpitaux de Paris (AP-HP), Hôpital Pitié-Salpêtrière, Paris, FranceSorbonne Université, Inserm, Centre d’Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, France0Assistance Publique–Hôpitaux de Paris (APHP), Sorbonne-Université, Hôpital Pitié–Salpêtrière, Département de Gériatrie, Paris, France1Critical Care Department, Germans Trias i Pujol University Hospital, Badalona, Spain2Department of Medicine Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), SpainSorbonne Université, Inserm, Centre d’Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, FranceAssistance Publique-Hôpitaux de Paris (AP-HP), Groupement Hospitalier Pitié-Salpêtrière, Département d’Immunologie, Paris, FranceDivision of Immunology, Germans Trias i Pujol University Hospital and Research Institute, Badalona, SpainDepartment of Cellular Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), SpainSorbonne Université, Inserm, Centre d’Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, FranceHighlightsInnate immune activation during Covid-19 infection is associated with pernicious clinical outcome.BackgroundCoronavirus disease 2019 (Covid-19) is a worldwide threat that has already caused more than 3 000 000 deaths. It is characterized by different patterns of disease evolution depending on host factors among which old-age and pre-existing comorbidities play a detrimental role. Previous coronavirus epidemics, notably SARS-CoV, were associated with increased serum neopterin levels, which can be interpreted as a sign of acute innate immunity in response to viral infection. Here we hypothesize that neopterin may serve as a biomarker of SARS-CoV-2 viral infection and Covid-19 disease severity.MethodsWe measured neopterin blood levels by ELISA. Seric concentration was quantified from 256 healthy donors and 374 Covid-19 patients at hospital admission. Enrolled Covid-19 patients were all symptomatic and displayed a large spectrum of comorbidities. Patients were followed until disease resolution or death.ResultsSevere and critically ill SARS-CoV-2 infected patients were characterized by a profound exacerbation of immune activation characterized by elevated neopterin blood levels. Systemic neopterin levels above 19nM stratified healthy individuals from Covid-19 patients with 87% specificity and 100% sensitivity. Moreover, systemic neopterin levels above 53nM differentiated non-survivors from survivors with 64% specificity and 100% sensitivity.ConclusionWe propose that neopterin concentration measured at arrival to hospital is a hallmark of severe Covid-19 and identifies a high-risk population of pernicious clinical outcome with a need for special medical care.https://www.frontiersin.org/articles/10.3389/fcimb.2021.709893/fullSARS-CoV-2biomarkerneopterinclinical outcomedeath |
| spellingShingle | Manon Chauvin Martin Larsen Bibiana Quirant Bibiana Quirant Paul Quentric Karim Dorgham Luca Royer Hélène Vallet Hélène Vallet Amelie Guihot Amelie Guihot Béhazine Combadière Christophe Combadière Jaume Barallat Julien Mayaux Charles-Edouard Luyt Alexis Mathian Alexis Mathian Zahir Amoura Zahir Amoura Jacques Boddaert Jacques Boddaert Fernando Armestar Fernando Armestar Guy Gorochov Guy Gorochov Eva Martinez-Caceres Eva Martinez-Caceres Delphine Sauce Elevated Neopterin Levels Predict Fatal Outcome in SARS-CoV-2-Infected Patients Frontiers in Cellular and Infection Microbiology SARS-CoV-2 biomarker neopterin clinical outcome death |
| title | Elevated Neopterin Levels Predict Fatal Outcome in SARS-CoV-2-Infected Patients |
| title_full | Elevated Neopterin Levels Predict Fatal Outcome in SARS-CoV-2-Infected Patients |
| title_fullStr | Elevated Neopterin Levels Predict Fatal Outcome in SARS-CoV-2-Infected Patients |
| title_full_unstemmed | Elevated Neopterin Levels Predict Fatal Outcome in SARS-CoV-2-Infected Patients |
| title_short | Elevated Neopterin Levels Predict Fatal Outcome in SARS-CoV-2-Infected Patients |
| title_sort | elevated neopterin levels predict fatal outcome in sars cov 2 infected patients |
| topic | SARS-CoV-2 biomarker neopterin clinical outcome death |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2021.709893/full |
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