Perovskite quantum dots modulating upconversion nanomaterials for cancer early detections
Abstract The accurate diagnosis and treatment of cancer cell lesions need a high standard of detection technology. Fluorescent probes to perform cancer biomarker detection have become a popular research issue. However, fluorescent probes still face enormous challenges of complex design and difficult...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | Cancer Nanotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12645-023-00206-6 |
| _version_ | 1797827685763776512 |
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| author | Yue He Hongtao Rao JingJing Wang Ying Wu Caiqin Han Changchun Yan Hunter Temple Le Zhang Wei Chen Ying Liu |
| author_facet | Yue He Hongtao Rao JingJing Wang Ying Wu Caiqin Han Changchun Yan Hunter Temple Le Zhang Wei Chen Ying Liu |
| author_sort | Yue He |
| collection | DOAJ |
| description | Abstract The accurate diagnosis and treatment of cancer cell lesions need a high standard of detection technology. Fluorescent probes to perform cancer biomarker detection have become a popular research issue. However, fluorescent probes still face enormous challenges of complex design and difficult detection. In this work, we propose a novel composite material UCNP@SiO2 + QDs based on the combination of rare earth upconversion (UCNPs) and perovskite quantum dots (QDs) and design a new fluorescent probe MB-UCNP@SiO2 + QDs with molecular beacon (MB) as the carrier, that can be excited by near-infrared light, emitted in the visible wavelength, specifically identified and highly sensitive. Under the excitation of 980 nm near-infrared light, the UCNPs and QDs in the composite produced the maximum efficiency of energy transfer through fluorescence resonance, and the multi-emission light of UCNPs synergistically excited the re-emission of QDs, and the energy transfer efficiency is 70.6%. By changing the doping ratio of QDs halogen elements in UCNP@SiO2 + QDs, it is possible to modulate the precise luminescence of UCNP@SiO2 + QDs in the entire wavelength range of visible light at different positions. The novel fluorescent probe is obtained using UCNP@SiO2 + QDs and Black Hole Quencher-1 (BHQ1) quenching groups linked to the two respective sides of MB, selecting as the target of detection the myeloma cancer biomarker miRNA-155, a difficult diagnostic and complex developmental type, and have achieved specific recognition and low concentration of miRNA-155 and a detection limit of 73.5 pM. This fluorescent probe design can provide new ideas for the early diagnosis and treatment of cancer, tumors, and cardiovascular diseases. Graphical Abstract |
| first_indexed | 2024-04-09T12:52:19Z |
| format | Article |
| id | doaj.art-0d581746801b4c62b80f1c06cbd8d1bf |
| institution | Directory Open Access Journal |
| issn | 1868-6958 1868-6966 |
| language | English |
| last_indexed | 2024-04-09T12:52:19Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Nanotechnology |
| spelling | doaj.art-0d581746801b4c62b80f1c06cbd8d1bf2023-05-14T11:08:14ZengBMCCancer Nanotechnology1868-69581868-69662023-05-0114111910.1186/s12645-023-00206-6Perovskite quantum dots modulating upconversion nanomaterials for cancer early detectionsYue He0Hongtao Rao1JingJing Wang2Ying Wu3Caiqin Han4Changchun Yan5Hunter Temple6Le Zhang7Wei Chen8Ying Liu9Jiangsu Key Laboratory of Advanced Laser Materials and Devices, School of Physics and Electronic Engineering, Jiangsu Normal UniversityJiangsu Key Laboratory of Advanced Laser Materials and Devices, School of Physics and Electronic Engineering, Jiangsu Normal UniversityJiangsu Key Laboratory of Advanced Laser Materials and Devices, School of Physics and Electronic Engineering, Jiangsu Normal UniversityJiangsu Key Laboratory of Advanced Laser Materials and Devices, School of Physics and Electronic Engineering, Jiangsu Normal UniversityJiangsu Key Laboratory of Advanced Laser Materials and Devices, School of Physics and Electronic Engineering, Jiangsu Normal UniversityJiangsu Key Laboratory of Advanced Laser Materials and Devices, School of Physics and Electronic Engineering, Jiangsu Normal UniversityDepartment of Physics, The University of Texas at ArlingtonJiangsu Key Laboratory of Advanced Laser Materials and Devices, School of Physics and Electronic Engineering, Jiangsu Normal UniversityDepartment of Physics, The University of Texas at ArlingtonJiangsu Key Laboratory of Advanced Laser Materials and Devices, School of Physics and Electronic Engineering, Jiangsu Normal UniversityAbstract The accurate diagnosis and treatment of cancer cell lesions need a high standard of detection technology. Fluorescent probes to perform cancer biomarker detection have become a popular research issue. However, fluorescent probes still face enormous challenges of complex design and difficult detection. In this work, we propose a novel composite material UCNP@SiO2 + QDs based on the combination of rare earth upconversion (UCNPs) and perovskite quantum dots (QDs) and design a new fluorescent probe MB-UCNP@SiO2 + QDs with molecular beacon (MB) as the carrier, that can be excited by near-infrared light, emitted in the visible wavelength, specifically identified and highly sensitive. Under the excitation of 980 nm near-infrared light, the UCNPs and QDs in the composite produced the maximum efficiency of energy transfer through fluorescence resonance, and the multi-emission light of UCNPs synergistically excited the re-emission of QDs, and the energy transfer efficiency is 70.6%. By changing the doping ratio of QDs halogen elements in UCNP@SiO2 + QDs, it is possible to modulate the precise luminescence of UCNP@SiO2 + QDs in the entire wavelength range of visible light at different positions. The novel fluorescent probe is obtained using UCNP@SiO2 + QDs and Black Hole Quencher-1 (BHQ1) quenching groups linked to the two respective sides of MB, selecting as the target of detection the myeloma cancer biomarker miRNA-155, a difficult diagnostic and complex developmental type, and have achieved specific recognition and low concentration of miRNA-155 and a detection limit of 73.5 pM. This fluorescent probe design can provide new ideas for the early diagnosis and treatment of cancer, tumors, and cardiovascular diseases. Graphical Abstracthttps://doi.org/10.1186/s12645-023-00206-6UpconversionPerovskite quantum dotsFluorescence resonanceMiRNA-155 |
| spellingShingle | Yue He Hongtao Rao JingJing Wang Ying Wu Caiqin Han Changchun Yan Hunter Temple Le Zhang Wei Chen Ying Liu Perovskite quantum dots modulating upconversion nanomaterials for cancer early detections Cancer Nanotechnology Upconversion Perovskite quantum dots Fluorescence resonance MiRNA-155 |
| title | Perovskite quantum dots modulating upconversion nanomaterials for cancer early detections |
| title_full | Perovskite quantum dots modulating upconversion nanomaterials for cancer early detections |
| title_fullStr | Perovskite quantum dots modulating upconversion nanomaterials for cancer early detections |
| title_full_unstemmed | Perovskite quantum dots modulating upconversion nanomaterials for cancer early detections |
| title_short | Perovskite quantum dots modulating upconversion nanomaterials for cancer early detections |
| title_sort | perovskite quantum dots modulating upconversion nanomaterials for cancer early detections |
| topic | Upconversion Perovskite quantum dots Fluorescence resonance MiRNA-155 |
| url | https://doi.org/10.1186/s12645-023-00206-6 |
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