Distinct expression and prognostic values of GATA transcription factor family in human ovarian cancer
Abstract Accumulated studies have provided controversial evidences of expression patterns and prognostic value of the GATA family in human ovarian cancer. In the present study, we accessed the distinct expression and prognostic roles of 7 individual members of GATA family in ovarian cancer (OC) pati...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | Journal of Ovarian Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13048-022-00974-6 |
| _version_ | 1828077006110064640 |
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| author | Quan Zhou Huai-jie Yang Man-zhen Zuo Ya-ling Tao |
| author_facet | Quan Zhou Huai-jie Yang Man-zhen Zuo Ya-ling Tao |
| author_sort | Quan Zhou |
| collection | DOAJ |
| description | Abstract Accumulated studies have provided controversial evidences of expression patterns and prognostic value of the GATA family in human ovarian cancer. In the present study, we accessed the distinct expression and prognostic roles of 7 individual members of GATA family in ovarian cancer (OC) patients through Oncomine analysis, CCLE analysis, Human Protein Atlas (HPA), Kaplan–Meier plotter (KM plotter) database, cBioPortal and Metascape. Our results indicated that GATA1, GATA3, GATA4 and TRPS1 mRNA and protein expression was significantly higher in OC than normal samples. High expression of GATA1, GATA2, and GATA4 were significantly correlated with better overall survival (OS), while increased GATA3 and GATA6 expression were associated with worse prognosis in OC patients. GATA1, GATA2, GATA3 and GATA6 were closely related to the different pathological histology, pathological grade, clinical stage and TP53 mutation status of OC. The genetic variation and interaction of the GATA family may be closely related to the pathogenesis and prognosis of OC, and the regulatory network composed of GATA family genes and their neighboring genes are mainly involved in Notch signaling pathway, Th1 and Th2 cell differentiation and Hippo signaling pathway. Transcriptional GATA1/2/3/4/6 could be prognostic markers and potential therapeutic target for OC patients. |
| first_indexed | 2024-04-11T02:23:19Z |
| format | Article |
| id | doaj.art-0d586c0a282b4ff78586738bedbb9c68 |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-11T02:23:19Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-0d586c0a282b4ff78586738bedbb9c682023-01-02T22:57:42ZengBMCJournal of Ovarian Research1757-22152022-04-0115111410.1186/s13048-022-00974-6Distinct expression and prognostic values of GATA transcription factor family in human ovarian cancerQuan Zhou0Huai-jie Yang1Man-zhen Zuo2Ya-ling Tao3Department of Gynecology and Obstetrics, the People’s Hospital of China Three Gorges University/the First People’s Hospital of YichangDepartment of Gynecology and Obstetrics, the People’s Hospital of China Three Gorges University/the First People’s Hospital of YichangDepartment of Gynecology and Obstetrics, the People’s Hospital of China Three Gorges University/the First People’s Hospital of YichangDepartment of Gynecology and Obstetrics, the People’s Hospital of China Three Gorges University/the First People’s Hospital of YichangAbstract Accumulated studies have provided controversial evidences of expression patterns and prognostic value of the GATA family in human ovarian cancer. In the present study, we accessed the distinct expression and prognostic roles of 7 individual members of GATA family in ovarian cancer (OC) patients through Oncomine analysis, CCLE analysis, Human Protein Atlas (HPA), Kaplan–Meier plotter (KM plotter) database, cBioPortal and Metascape. Our results indicated that GATA1, GATA3, GATA4 and TRPS1 mRNA and protein expression was significantly higher in OC than normal samples. High expression of GATA1, GATA2, and GATA4 were significantly correlated with better overall survival (OS), while increased GATA3 and GATA6 expression were associated with worse prognosis in OC patients. GATA1, GATA2, GATA3 and GATA6 were closely related to the different pathological histology, pathological grade, clinical stage and TP53 mutation status of OC. The genetic variation and interaction of the GATA family may be closely related to the pathogenesis and prognosis of OC, and the regulatory network composed of GATA family genes and their neighboring genes are mainly involved in Notch signaling pathway, Th1 and Th2 cell differentiation and Hippo signaling pathway. Transcriptional GATA1/2/3/4/6 could be prognostic markers and potential therapeutic target for OC patients.https://doi.org/10.1186/s13048-022-00974-6GATAOvarian cancerPrognosisKM plotter |
| spellingShingle | Quan Zhou Huai-jie Yang Man-zhen Zuo Ya-ling Tao Distinct expression and prognostic values of GATA transcription factor family in human ovarian cancer Journal of Ovarian Research GATA Ovarian cancer Prognosis KM plotter |
| title | Distinct expression and prognostic values of GATA transcription factor family in human ovarian cancer |
| title_full | Distinct expression and prognostic values of GATA transcription factor family in human ovarian cancer |
| title_fullStr | Distinct expression and prognostic values of GATA transcription factor family in human ovarian cancer |
| title_full_unstemmed | Distinct expression and prognostic values of GATA transcription factor family in human ovarian cancer |
| title_short | Distinct expression and prognostic values of GATA transcription factor family in human ovarian cancer |
| title_sort | distinct expression and prognostic values of gata transcription factor family in human ovarian cancer |
| topic | GATA Ovarian cancer Prognosis KM plotter |
| url | https://doi.org/10.1186/s13048-022-00974-6 |
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