Central sleep apnoea and periodic breathing in heart failure: prognostic significance and treatment options
Central sleep apnoea (CSA) including periodic breathing is prevalent in more than one-third of patients with heart failure and is highly and independently associated with poor outcomes. Optimal treatment is still debated and well-conducted studies regarding efficacy and impact on outcomes of availab...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2019-10-01
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| Series: | European Respiratory Review |
| Online Access: | http://err.ersjournals.com/content/28/153/190084.full |
| _version_ | 1818526352247095296 |
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| author | Winfried Randerath Oana Deleanu Sofia Schiza Jean-Louis Pepin |
| author_facet | Winfried Randerath Oana Deleanu Sofia Schiza Jean-Louis Pepin |
| author_sort | Winfried Randerath |
| collection | DOAJ |
| description | Central sleep apnoea (CSA) including periodic breathing is prevalent in more than one-third of patients with heart failure and is highly and independently associated with poor outcomes. Optimal treatment is still debated and well-conducted studies regarding efficacy and impact on outcomes of available treatment options are limited, particularly in cardiac failure with preserved ejection fraction. While continuous positive airway pressure and oxygen reduce breathing disturbances by 50%, adaptive servoventilation (ASV) normalises breathing disturbances by to controlling the underlying mechanism of CSA. Results are contradictory regarding impact of ASV on hard outcomes. Cohorts and registry studies show survival improvement under ASV, while secondary analyses of the large SERVE-HF randomised trial showed an excess mortality in cardiac failure with reduced ejection fraction. The current priority is to understand which phenotypes of cardiac failure patients may benefit from treatment guiding individualised and personalised management. |
| first_indexed | 2024-12-11T06:21:48Z |
| format | Article |
| id | doaj.art-0d592a2e982b44f9aa83a7c89ead4556 |
| institution | Directory Open Access Journal |
| issn | 0905-9180 1600-0617 |
| language | English |
| last_indexed | 2024-12-11T06:21:48Z |
| publishDate | 2019-10-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | European Respiratory Review |
| spelling | doaj.art-0d592a2e982b44f9aa83a7c89ead45562022-12-22T01:17:47ZengEuropean Respiratory SocietyEuropean Respiratory Review0905-91801600-06172019-10-012815310.1183/16000617.0084-20190084-2019Central sleep apnoea and periodic breathing in heart failure: prognostic significance and treatment optionsWinfried Randerath0Oana Deleanu1Sofia Schiza2Jean-Louis Pepin3 Institute of Pneumology at the University of Cologne, Bethanien Hospital, Clinic for Pneumology and Allergology, Centre of Sleep Medicine and Respiratory Care, Solingen, Germany University of Medicine and Pharmacy “Carol Davila” and Institute of Pneumology “Marius Nasta” Bucharest, Bucharest, Romania Sofia Schiza, University of Crete, Heraklion, Greece Laboratoire du sommeil explorations fonctionnelle Respire, Centre Hospitalier Universitaire Grenoble, Grenoble, France Central sleep apnoea (CSA) including periodic breathing is prevalent in more than one-third of patients with heart failure and is highly and independently associated with poor outcomes. Optimal treatment is still debated and well-conducted studies regarding efficacy and impact on outcomes of available treatment options are limited, particularly in cardiac failure with preserved ejection fraction. While continuous positive airway pressure and oxygen reduce breathing disturbances by 50%, adaptive servoventilation (ASV) normalises breathing disturbances by to controlling the underlying mechanism of CSA. Results are contradictory regarding impact of ASV on hard outcomes. Cohorts and registry studies show survival improvement under ASV, while secondary analyses of the large SERVE-HF randomised trial showed an excess mortality in cardiac failure with reduced ejection fraction. The current priority is to understand which phenotypes of cardiac failure patients may benefit from treatment guiding individualised and personalised management.http://err.ersjournals.com/content/28/153/190084.full |
| spellingShingle | Winfried Randerath Oana Deleanu Sofia Schiza Jean-Louis Pepin Central sleep apnoea and periodic breathing in heart failure: prognostic significance and treatment options European Respiratory Review |
| title | Central sleep apnoea and periodic breathing in heart failure: prognostic significance and treatment options |
| title_full | Central sleep apnoea and periodic breathing in heart failure: prognostic significance and treatment options |
| title_fullStr | Central sleep apnoea and periodic breathing in heart failure: prognostic significance and treatment options |
| title_full_unstemmed | Central sleep apnoea and periodic breathing in heart failure: prognostic significance and treatment options |
| title_short | Central sleep apnoea and periodic breathing in heart failure: prognostic significance and treatment options |
| title_sort | central sleep apnoea and periodic breathing in heart failure prognostic significance and treatment options |
| url | http://err.ersjournals.com/content/28/153/190084.full |
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