Potential role of chitosan, PLGA and iron oxide nanoparticles in Parkinson’s disease therapy
Abstract Background Parkinson's disease (PD) is a debilitating disease that alters an individual's functionality. Parkinsonism is a complex symptom consisting of numerous motor and non-motor features, and although several disorders are responsible, PD remains the most important. Several th...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-06-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41983-022-00503-8 |
| _version_ | 1811240055154409472 |
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| author | Ahmed Hafez Mousa Salwa Agha Mohammad |
| author_facet | Ahmed Hafez Mousa Salwa Agha Mohammad |
| author_sort | Ahmed Hafez Mousa |
| collection | DOAJ |
| description | Abstract Background Parkinson's disease (PD) is a debilitating disease that alters an individual's functionality. Parkinsonism is a complex symptom consisting of numerous motor and non-motor features, and although several disorders are responsible, PD remains the most important. Several theories have been proposed for the characteristic pathological changes, the most important of which is the loss of dopaminergic neurons associated with a reduced ability to perform voluntary movements. Many drugs have been developed over the years to treat the condition and prevent its progression, but drug delivery is still a challenge due to the blood–brain barrier, which prevents the passage of drugs into the central nervous system. However, with the advances in nanotechnology in the medical field, there is growing hope of overcoming this challenge. Summary Our review highlights the potential role of three commonly studied nanoparticles in laboratory-induced animal models of PD: chitosan, PLGA, and iron oxide nanoparticles as potential PD therapy in humans. |
| first_indexed | 2024-04-12T13:13:41Z |
| format | Article |
| id | doaj.art-0d5c60b932674d3ab66e3ff7fa7a26a5 |
| institution | Directory Open Access Journal |
| issn | 1687-8329 |
| language | English |
| last_indexed | 2024-04-12T13:13:41Z |
| publishDate | 2022-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj.art-0d5c60b932674d3ab66e3ff7fa7a26a52022-12-22T03:31:47ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292022-06-015811810.1186/s41983-022-00503-8Potential role of chitosan, PLGA and iron oxide nanoparticles in Parkinson’s disease therapyAhmed Hafez Mousa0Salwa Agha Mohammad1College of Medicine, Batterjee Medical CollegeCollege of Medicine, Batterjee Medical CollegeAbstract Background Parkinson's disease (PD) is a debilitating disease that alters an individual's functionality. Parkinsonism is a complex symptom consisting of numerous motor and non-motor features, and although several disorders are responsible, PD remains the most important. Several theories have been proposed for the characteristic pathological changes, the most important of which is the loss of dopaminergic neurons associated with a reduced ability to perform voluntary movements. Many drugs have been developed over the years to treat the condition and prevent its progression, but drug delivery is still a challenge due to the blood–brain barrier, which prevents the passage of drugs into the central nervous system. However, with the advances in nanotechnology in the medical field, there is growing hope of overcoming this challenge. Summary Our review highlights the potential role of three commonly studied nanoparticles in laboratory-induced animal models of PD: chitosan, PLGA, and iron oxide nanoparticles as potential PD therapy in humans.https://doi.org/10.1186/s41983-022-00503-8Parkinson’s diseaseNanotechnologyNanoparticlesChitosanPLGAIron oxide |
| spellingShingle | Ahmed Hafez Mousa Salwa Agha Mohammad Potential role of chitosan, PLGA and iron oxide nanoparticles in Parkinson’s disease therapy The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Parkinson’s disease Nanotechnology Nanoparticles Chitosan PLGA Iron oxide |
| title | Potential role of chitosan, PLGA and iron oxide nanoparticles in Parkinson’s disease therapy |
| title_full | Potential role of chitosan, PLGA and iron oxide nanoparticles in Parkinson’s disease therapy |
| title_fullStr | Potential role of chitosan, PLGA and iron oxide nanoparticles in Parkinson’s disease therapy |
| title_full_unstemmed | Potential role of chitosan, PLGA and iron oxide nanoparticles in Parkinson’s disease therapy |
| title_short | Potential role of chitosan, PLGA and iron oxide nanoparticles in Parkinson’s disease therapy |
| title_sort | potential role of chitosan plga and iron oxide nanoparticles in parkinson s disease therapy |
| topic | Parkinson’s disease Nanotechnology Nanoparticles Chitosan PLGA Iron oxide |
| url | https://doi.org/10.1186/s41983-022-00503-8 |
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