A conserved glutathione binding site in poliovirus is a target for antivirals and vaccine stabilisation
Cryo-EM structures reveal the role of glutathione (GSH) in poliovirus (PV) serotype 3 virus-like particle (VLP) stability, suggesting GSH or an analogous tight-binding antiviral offers potential for stabilizing VLP vaccines against PV.
Bibliographic Details
Main Authors: |
Mohammad W. Bahar,
Veronica Nasta,
Helen Fox,
Lee Sherry,
Keith Grehan,
Claudine Porta,
Andrew J. Macadam,
Nicola J. Stonehouse,
David J. Rowlands,
Elizabeth E. Fry,
David I. Stuart |
Format: | Article
|
Language: | English |
Published: |
Nature Portfolio
2022-11-01
|
Series: | Communications Biology
|
Online Access: | https://doi.org/10.1038/s42003-022-04252-5
|