Immune regulation during chronic visceral leishmaniasis.
Visceral leishmaniasis is a chronic parasitic disease associated with severe immune dysfunction. Treatment options are limited to relatively toxic drugs, and there is no vaccine for humans available. Hence, there is an urgent need to better understand immune responses following infection with Leishm...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-07-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | http://europepmc.org/articles/PMC4091888?pdf=render |
| _version_ | 1819021548907921408 |
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| author | Rebecca J Faleiro Rajiv Kumar Louise M Hafner Christian R Engwerda |
| author_facet | Rebecca J Faleiro Rajiv Kumar Louise M Hafner Christian R Engwerda |
| author_sort | Rebecca J Faleiro |
| collection | DOAJ |
| description | Visceral leishmaniasis is a chronic parasitic disease associated with severe immune dysfunction. Treatment options are limited to relatively toxic drugs, and there is no vaccine for humans available. Hence, there is an urgent need to better understand immune responses following infection with Leishmania species by studying animal models of disease and clinical samples from patients. Here, we review recent discoveries in these areas and highlight shortcomings in our knowledge that need to be addressed if better treatment options are to be developed and effective vaccines designed. |
| first_indexed | 2024-12-21T04:08:52Z |
| format | Article |
| id | doaj.art-0d5dc2a5687544f6ba10ae24288b0cfa |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-12-21T04:08:52Z |
| publishDate | 2014-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-0d5dc2a5687544f6ba10ae24288b0cfa2022-12-21T19:16:31ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352014-07-0187e291410.1371/journal.pntd.0002914Immune regulation during chronic visceral leishmaniasis.Rebecca J FaleiroRajiv KumarLouise M HafnerChristian R EngwerdaVisceral leishmaniasis is a chronic parasitic disease associated with severe immune dysfunction. Treatment options are limited to relatively toxic drugs, and there is no vaccine for humans available. Hence, there is an urgent need to better understand immune responses following infection with Leishmania species by studying animal models of disease and clinical samples from patients. Here, we review recent discoveries in these areas and highlight shortcomings in our knowledge that need to be addressed if better treatment options are to be developed and effective vaccines designed.http://europepmc.org/articles/PMC4091888?pdf=render |
| spellingShingle | Rebecca J Faleiro Rajiv Kumar Louise M Hafner Christian R Engwerda Immune regulation during chronic visceral leishmaniasis. PLoS Neglected Tropical Diseases |
| title | Immune regulation during chronic visceral leishmaniasis. |
| title_full | Immune regulation during chronic visceral leishmaniasis. |
| title_fullStr | Immune regulation during chronic visceral leishmaniasis. |
| title_full_unstemmed | Immune regulation during chronic visceral leishmaniasis. |
| title_short | Immune regulation during chronic visceral leishmaniasis. |
| title_sort | immune regulation during chronic visceral leishmaniasis |
| url | http://europepmc.org/articles/PMC4091888?pdf=render |
| work_keys_str_mv | AT rebeccajfaleiro immuneregulationduringchronicvisceralleishmaniasis AT rajivkumar immuneregulationduringchronicvisceralleishmaniasis AT louisemhafner immuneregulationduringchronicvisceralleishmaniasis AT christianrengwerda immuneregulationduringchronicvisceralleishmaniasis |