Instrumental and laboratory assessment of stressful remodelling processes in bone tissue at total hip replacement
Research objective is to estimate stressful remodelling features of bone tissue according to the densitometry data and to the level of biochemical markers of bone resorption and formation in total hip replacement (THR). Bone tissue mineral density (BTMD), condition of calcium-phosphoric metabolism a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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Saratov State Medical University
2010-06-01
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| Series: | Саратовский научно-медицинский журнал |
| Subjects: | |
| Online Access: | http://www.ssmj.ru/system/files/201002_423_428.pdf |
| _version_ | 1819279928592433152 |
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| author | E.V. Karjakina E.A. Persova E.V. Gladkova |
| author_facet | E.V. Karjakina E.A. Persova E.V. Gladkova |
| author_sort | E.V. Karjakina |
| collection | DOAJ |
| description | Research objective is to estimate stressful remodelling features of bone tissue according to the densitometry data and to the level of biochemical markers of bone resorption and formation in total hip replacement (THR). Bone tissue mineral density (BTMD), condition of calcium-phosphoric metabolism and biochemical markers of bone formation (osteocalcin and bone isoenzyme of alkaline phosphatase) and resorption (С-terminal bodypeptide of the I type collagen) have been determined in 52 patients with coxarthrosis of ll-lll stages with marked joint dysfunction before and after THR. The control group included 24 donors. The data were considered to be reliable when the probability index was р<0,05. The reliable (р<0,05) change of BTMD was determined only in 3-6 months after the operation, whereas the change of biochemical markers of remodeling had already been done after 1,5-3 months, allowing to define the group of patients with obvious negative bone balance: strong predominance of resorption processes without compensation of the subsequent adequate osteogenesis, that subsequently could lead to significant bone tissue deficiency in the area adjacent to the endoprosthesis. Changes of indices of calcium-phosphoric metabolism were not certain during the investigation term. ln conclusion it is to state that biochemical markers of remodeling in comparison with BTMD allow to estimate objectively features of adaptive bone tissue remodeling after THR in earlier periods and to define group of patients with sharp intensification of metabolism and obvious negative bone balance |
| first_indexed | 2024-12-24T00:35:42Z |
| format | Article |
| id | doaj.art-0d5e832918214339bbeac9a978cc80ab |
| institution | Directory Open Access Journal |
| issn | 1995-0039 2076-2518 |
| language | Russian |
| last_indexed | 2024-12-24T00:35:42Z |
| publishDate | 2010-06-01 |
| publisher | Saratov State Medical University |
| record_format | Article |
| series | Саратовский научно-медицинский журнал |
| spelling | doaj.art-0d5e832918214339bbeac9a978cc80ab2022-12-21T17:24:05ZrusSaratov State Medical UniversityСаратовский научно-медицинский журнал1995-00392076-25182010-06-0162423428Instrumental and laboratory assessment of stressful remodelling processes in bone tissue at total hip replacementE.V. KarjakinaE.A. PersovaE.V. GladkovaResearch objective is to estimate stressful remodelling features of bone tissue according to the densitometry data and to the level of biochemical markers of bone resorption and formation in total hip replacement (THR). Bone tissue mineral density (BTMD), condition of calcium-phosphoric metabolism and biochemical markers of bone formation (osteocalcin and bone isoenzyme of alkaline phosphatase) and resorption (С-terminal bodypeptide of the I type collagen) have been determined in 52 patients with coxarthrosis of ll-lll stages with marked joint dysfunction before and after THR. The control group included 24 donors. The data were considered to be reliable when the probability index was р<0,05. The reliable (р<0,05) change of BTMD was determined only in 3-6 months after the operation, whereas the change of biochemical markers of remodeling had already been done after 1,5-3 months, allowing to define the group of patients with obvious negative bone balance: strong predominance of resorption processes without compensation of the subsequent adequate osteogenesis, that subsequently could lead to significant bone tissue deficiency in the area adjacent to the endoprosthesis. Changes of indices of calcium-phosphoric metabolism were not certain during the investigation term. ln conclusion it is to state that biochemical markers of remodeling in comparison with BTMD allow to estimate objectively features of adaptive bone tissue remodeling after THR in earlier periods and to define group of patients with sharp intensification of metabolism and obvious negative bone balancehttp://www.ssmj.ru/system/files/201002_423_428.pdfbiochemical markersbone tissue remodellingcoxarthrosiship joint |
| spellingShingle | E.V. Karjakina E.A. Persova E.V. Gladkova Instrumental and laboratory assessment of stressful remodelling processes in bone tissue at total hip replacement Саратовский научно-медицинский журнал biochemical markers bone tissue remodelling coxarthrosis hip joint |
| title | Instrumental and laboratory assessment of stressful remodelling processes in bone tissue at total hip replacement |
| title_full | Instrumental and laboratory assessment of stressful remodelling processes in bone tissue at total hip replacement |
| title_fullStr | Instrumental and laboratory assessment of stressful remodelling processes in bone tissue at total hip replacement |
| title_full_unstemmed | Instrumental and laboratory assessment of stressful remodelling processes in bone tissue at total hip replacement |
| title_short | Instrumental and laboratory assessment of stressful remodelling processes in bone tissue at total hip replacement |
| title_sort | instrumental and laboratory assessment of stressful remodelling processes in bone tissue at total hip replacement |
| topic | biochemical markers bone tissue remodelling coxarthrosis hip joint |
| url | http://www.ssmj.ru/system/files/201002_423_428.pdf |
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