The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics
MicroRNAs are small noncoding transcripts that posttranscriptionally regulate gene expression via base-pairing complementarity. Their role in cancer can be related to tumor suppression or oncogenic function. Moreover, they have been linked to processes recognized as hallmarks of cancer, such as apop...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | Molecular Therapy: Nucleic Acids |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2162253120300949 |
| _version_ | 1819182043464990720 |
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| author | Diana Bautista-Sánchez Cristian Arriaga-Canon Abraham Pedroza-Torres Inti Alberto De La Rosa-Velázquez Rodrigo González-Barrios Laura Contreras-Espinosa Rogelio Montiel-Manríquez Clementina Castro-Hernández Verónica Fragoso-Ontiveros Rosa María Álvarez-Gómez Luis A. Herrera |
| author_facet | Diana Bautista-Sánchez Cristian Arriaga-Canon Abraham Pedroza-Torres Inti Alberto De La Rosa-Velázquez Rodrigo González-Barrios Laura Contreras-Espinosa Rogelio Montiel-Manríquez Clementina Castro-Hernández Verónica Fragoso-Ontiveros Rosa María Álvarez-Gómez Luis A. Herrera |
| author_sort | Diana Bautista-Sánchez |
| collection | DOAJ |
| description | MicroRNAs are small noncoding transcripts that posttranscriptionally regulate gene expression via base-pairing complementarity. Their role in cancer can be related to tumor suppression or oncogenic function. Moreover, they have been linked to processes recognized as hallmarks of cancer, such as apoptosis, invasion, metastasis, and proliferation. Particularly, one of the first oncomiRs found upregulated in a variety of cancers, such as gliomas, breast cancer, and colorectal cancer, was microRNA-21 (miR-21). Some of its target genes associated with cancer are PTEN (phosphatase and tensin homolog), PDCD4 (programmed cell death protein 4), RECK (reversion-inducing cysteine-rich protein with Kazal motifs), and STAT3 (signal transducer activator of transcription 3). As a result, miR-21 has been proposed as a plausible diagnostic and prognostic biomarker, as well as a therapeutic target for several types of cancer. Currently, research and clinical trials to inhibit miR-21 through anti-miR-21 oligonucleotides and ADM-21 are being conducted. As all of the evidence suggests, miR-21 is involved in carcinogenic processes; therefore, inhibiting it could have effects on more than one type of cancer. However, whether miR-21 can be used as a tissue-specific biomarker should be analyzed with caution. Consequently, the purpose of this review is to outline the available information and recent advances regarding miR-21 as a potential biomarker in the clinical setting and as a therapeutic target in cancer to highlight its importance in the era of precision medicine. |
| first_indexed | 2024-12-22T22:39:51Z |
| format | Article |
| id | doaj.art-0d5efdb5ce6a4e16ba0dcaaba9e07b87 |
| institution | Directory Open Access Journal |
| issn | 2162-2531 |
| language | English |
| last_indexed | 2024-12-22T22:39:51Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Nucleic Acids |
| spelling | doaj.art-0d5efdb5ce6a4e16ba0dcaaba9e07b872022-12-21T18:10:13ZengElsevierMolecular Therapy: Nucleic Acids2162-25312020-06-0120409420The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based TherapeuticsDiana Bautista-Sánchez0Cristian Arriaga-Canon1Abraham Pedroza-Torres2Inti Alberto De La Rosa-Velázquez3Rodrigo González-Barrios4Laura Contreras-Espinosa5Rogelio Montiel-Manríquez6Clementina Castro-Hernández7Verónica Fragoso-Ontiveros8Rosa María Álvarez-Gómez9Luis A. Herrera10Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, UNAM, Avenida San Fernando No. 22, Colonia Sección XVI, Tlalpan, CP 14080, Mexico City, MexicoUnidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, UNAM, Avenida San Fernando No. 22, Colonia Sección XVI, Tlalpan, CP 14080, Mexico City, MexicoCONACYT-Instituto Nacional de Cancerología, Avenida San Fernando No. 22, Colonia Sección XVI, Tlalpan, CP 14080, Mexico City, MexicoDepartment of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Stübeweg 51, 79108 Freiburg, GermanyUnidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, UNAM, Avenida San Fernando No. 22, Colonia Sección XVI, Tlalpan, CP 14080, Mexico City, MexicoUnidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, UNAM, Avenida San Fernando No. 22, Colonia Sección XVI, Tlalpan, CP 14080, Mexico City, MexicoUnidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, UNAM, Avenida San Fernando No. 22, Colonia Sección XVI, Tlalpan, CP 14080, Mexico City, MexicoUnidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, UNAM, Avenida San Fernando No. 22, Colonia Sección XVI, Tlalpan, CP 14080, Mexico City, MexicoClínica de Cáncer Hereditario, Instituto Nacional de Cancerología, Avenida San Fernando No. 22, Colonia Sección XVI, Tlalpan, CP 14080, Mexico City, MexicoClínica de Cáncer Hereditario, Instituto Nacional de Cancerología, Avenida San Fernando No. 22, Colonia Sección XVI, Tlalpan, CP 14080, Mexico City, MexicoUnidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, UNAM, Avenida San Fernando No. 22, Colonia Sección XVI, Tlalpan, CP 14080, Mexico City, Mexico; Instituto Nacional de Medicina Genómica, Periferico Sur 4809, Arenal Tepepan, Tlalpan, CP 14610, Mexico City, Mexico; Corresponding author: Luis A. Herrera, Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, UNAM, Avenida San Fernando No. 22, Colonia Sección XVI, Tlalpan. CP 14080, Mexico City, Mexico.MicroRNAs are small noncoding transcripts that posttranscriptionally regulate gene expression via base-pairing complementarity. Their role in cancer can be related to tumor suppression or oncogenic function. Moreover, they have been linked to processes recognized as hallmarks of cancer, such as apoptosis, invasion, metastasis, and proliferation. Particularly, one of the first oncomiRs found upregulated in a variety of cancers, such as gliomas, breast cancer, and colorectal cancer, was microRNA-21 (miR-21). Some of its target genes associated with cancer are PTEN (phosphatase and tensin homolog), PDCD4 (programmed cell death protein 4), RECK (reversion-inducing cysteine-rich protein with Kazal motifs), and STAT3 (signal transducer activator of transcription 3). As a result, miR-21 has been proposed as a plausible diagnostic and prognostic biomarker, as well as a therapeutic target for several types of cancer. Currently, research and clinical trials to inhibit miR-21 through anti-miR-21 oligonucleotides and ADM-21 are being conducted. As all of the evidence suggests, miR-21 is involved in carcinogenic processes; therefore, inhibiting it could have effects on more than one type of cancer. However, whether miR-21 can be used as a tissue-specific biomarker should be analyzed with caution. Consequently, the purpose of this review is to outline the available information and recent advances regarding miR-21 as a potential biomarker in the clinical setting and as a therapeutic target in cancer to highlight its importance in the era of precision medicine.http://www.sciencedirect.com/science/article/pii/S2162253120300949 |
| spellingShingle | Diana Bautista-Sánchez Cristian Arriaga-Canon Abraham Pedroza-Torres Inti Alberto De La Rosa-Velázquez Rodrigo González-Barrios Laura Contreras-Espinosa Rogelio Montiel-Manríquez Clementina Castro-Hernández Verónica Fragoso-Ontiveros Rosa María Álvarez-Gómez Luis A. Herrera The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics Molecular Therapy: Nucleic Acids |
| title | The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics |
| title_full | The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics |
| title_fullStr | The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics |
| title_full_unstemmed | The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics |
| title_short | The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics |
| title_sort | promising role of mir 21 as a cancer biomarker and its importance in rna based therapeutics |
| url | http://www.sciencedirect.com/science/article/pii/S2162253120300949 |
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