HLA-G 14bp Ins/Del Polymorphism in the 3′UTR Region and Acute Rejection in Kidney Transplant Recipients: An Updated Meta-Analysis
<i>Background and Objectives:</i> Acute kidney injury (AKI) affects the survival rate of kidney transplant organs and patients. Acute rejection (AR) due to AKI may lead to kidney transplantation failure. It is known that there is a relationship between human leukocyte antigen-G (HLA-G),...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/10/1007 |
| _version_ | 1797513939694649344 |
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| author | Sang Wook Kang Eunkyung Oh Wonwoo Cho Minseok Kim Eo Jin Park Kyu Hwan Kwack Kang Chung Ok Hyung Nam Yong Kwon Chae Ju Yeon Ban |
| author_facet | Sang Wook Kang Eunkyung Oh Wonwoo Cho Minseok Kim Eo Jin Park Kyu Hwan Kwack Kang Chung Ok Hyung Nam Yong Kwon Chae Ju Yeon Ban |
| author_sort | Sang Wook Kang |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> Acute kidney injury (AKI) affects the survival rate of kidney transplant organs and patients. Acute rejection (AR) due to AKI may lead to kidney transplantation failure. It is known that there is a relationship between human leukocyte antigen-G (HLA-G), which is involved in immune regulation, and AR in transplant patients. Moreover, 14-bp insertion/deletion polymorphism in the 3′ untranslated region (UTR) region of the HLA-G gene is known to affect HLA-G expression. However, its relationship to AR is still controversial. The aim of this study was to investigate whether HLA-G 14-bp insertion/deletion polymorphism contributed to the development of AR in kidney transplant patients using a meta-analysis. <i>Materials and Methods:</i> To perform our meta-analysis, eligible studies about HLA-G 14-bp insertion/deletion polymorphism and AR were searched in electronic databases until 1 June 2021. Finally, a total of 336 patients with AR and 952 patients without AR in relation to kidney transplantation were analyzed from a total of nine studies. <i>Results:</i> In our results, the Del allele and Ins/Del+Del/Del and Del/Del genotypes significantly increased susceptibility of AR in Asian populations [odds ratio (OR) = 2.359, 95% confidence interval (CI) = 1.568–3.550, <i>p</i> = 3.8 × 10<sup>−5</sup>; OR = 3.357, 95% CI = 1.769–6.370, <i>p</i> = 0.002; OR = 2.750, 95% CI = 1.354–5.587, <i>p</i> = 0.0052 in each model, respectively]. <i>Conclusions:</i> Evidence of the present results indicate that HLA-G 14-bp insertion/deletion polymorphism is associated with susceptibility to AR in the Asian population. |
| first_indexed | 2024-03-10T06:24:38Z |
| format | Article |
| id | doaj.art-0d5f891c609e4956979425c42075444b |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T06:24:38Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-0d5f891c609e4956979425c42075444b2023-11-22T19:03:17ZengMDPI AGMedicina1010-660X1648-91442021-09-015710100710.3390/medicina57101007HLA-G 14bp Ins/Del Polymorphism in the 3′UTR Region and Acute Rejection in Kidney Transplant Recipients: An Updated Meta-AnalysisSang Wook Kang0Eunkyung Oh1Wonwoo Cho2Minseok Kim3Eo Jin Park4Kyu Hwan Kwack5Kang Chung6Ok Hyung Nam7Yong Kwon Chae8Ju Yeon Ban9Department of Oral and Maxillofacial Pathology, School of Dentistry, Kyung Hee University, Seoul 02453, KoreaDepartment of Medicine, Graduate School, Kyung Hee University, Seoul 02453, KoreaDepartment of Medicine, Graduate School, Kyung Hee University, Seoul 02453, KoreaDepartment of Medicine, Graduate School, Kyung Hee University, Seoul 02453, KoreaDepartment of Physical Medicine and Rehabilitation, Graduate School, Kyung Hee University, Seoul 02453, KoreaDepartment of Oral Biology, University at Buffalo, Buffalo, NY 14214, USADepartment of Oral Anatomy and Developmental Biology, Graduate School of Dentistry, Kyung Hee University, Seoul 02453, KoreaDepartment of Pediatric Dentistry, School of Dentistry, Kyung Hee University, Seoul 02453, KoreaDepartment of Pediatric Dentistry, School of Dentistry, Kyung Hee University, Seoul 02453, KoreaDepartment of Dental Pharmacology, School of Dentistry, Dankook University, Cheonan 16890, Korea<i>Background and Objectives:</i> Acute kidney injury (AKI) affects the survival rate of kidney transplant organs and patients. Acute rejection (AR) due to AKI may lead to kidney transplantation failure. It is known that there is a relationship between human leukocyte antigen-G (HLA-G), which is involved in immune regulation, and AR in transplant patients. Moreover, 14-bp insertion/deletion polymorphism in the 3′ untranslated region (UTR) region of the HLA-G gene is known to affect HLA-G expression. However, its relationship to AR is still controversial. The aim of this study was to investigate whether HLA-G 14-bp insertion/deletion polymorphism contributed to the development of AR in kidney transplant patients using a meta-analysis. <i>Materials and Methods:</i> To perform our meta-analysis, eligible studies about HLA-G 14-bp insertion/deletion polymorphism and AR were searched in electronic databases until 1 June 2021. Finally, a total of 336 patients with AR and 952 patients without AR in relation to kidney transplantation were analyzed from a total of nine studies. <i>Results:</i> In our results, the Del allele and Ins/Del+Del/Del and Del/Del genotypes significantly increased susceptibility of AR in Asian populations [odds ratio (OR) = 2.359, 95% confidence interval (CI) = 1.568–3.550, <i>p</i> = 3.8 × 10<sup>−5</sup>; OR = 3.357, 95% CI = 1.769–6.370, <i>p</i> = 0.002; OR = 2.750, 95% CI = 1.354–5.587, <i>p</i> = 0.0052 in each model, respectively]. <i>Conclusions:</i> Evidence of the present results indicate that HLA-G 14-bp insertion/deletion polymorphism is associated with susceptibility to AR in the Asian population.https://www.mdpi.com/1648-9144/57/10/1007human leukocyte antigen GHLA-Gpolymorphismacute kidney injuryacute rejectionmeta-analysis |
| spellingShingle | Sang Wook Kang Eunkyung Oh Wonwoo Cho Minseok Kim Eo Jin Park Kyu Hwan Kwack Kang Chung Ok Hyung Nam Yong Kwon Chae Ju Yeon Ban HLA-G 14bp Ins/Del Polymorphism in the 3′UTR Region and Acute Rejection in Kidney Transplant Recipients: An Updated Meta-Analysis Medicina human leukocyte antigen G HLA-G polymorphism acute kidney injury acute rejection meta-analysis |
| title | HLA-G 14bp Ins/Del Polymorphism in the 3′UTR Region and Acute Rejection in Kidney Transplant Recipients: An Updated Meta-Analysis |
| title_full | HLA-G 14bp Ins/Del Polymorphism in the 3′UTR Region and Acute Rejection in Kidney Transplant Recipients: An Updated Meta-Analysis |
| title_fullStr | HLA-G 14bp Ins/Del Polymorphism in the 3′UTR Region and Acute Rejection in Kidney Transplant Recipients: An Updated Meta-Analysis |
| title_full_unstemmed | HLA-G 14bp Ins/Del Polymorphism in the 3′UTR Region and Acute Rejection in Kidney Transplant Recipients: An Updated Meta-Analysis |
| title_short | HLA-G 14bp Ins/Del Polymorphism in the 3′UTR Region and Acute Rejection in Kidney Transplant Recipients: An Updated Meta-Analysis |
| title_sort | hla g 14bp ins del polymorphism in the 3 utr region and acute rejection in kidney transplant recipients an updated meta analysis |
| topic | human leukocyte antigen G HLA-G polymorphism acute kidney injury acute rejection meta-analysis |
| url | https://www.mdpi.com/1648-9144/57/10/1007 |
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