Structure, function and mechanistic aspects of scorpion venom peptides - A boon for the development of novel therapeutics
Venom of scorpions is very expensive and lethal, yet with innumerable and exciting potential as a source for the development of biotherapeutics. One of the chief components of scorpion venom is the ‘peptides’ which have shown diverse array of biological activities, promising site specificity and are...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | European Journal of Medicinal Chemistry Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772417422000401 |
| _version_ | 1811294966278782976 |
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| author | R. Suhas |
| author_facet | R. Suhas |
| author_sort | R. Suhas |
| collection | DOAJ |
| description | Venom of scorpions is very expensive and lethal, yet with innumerable and exciting potential as a source for the development of biotherapeutics. One of the chief components of scorpion venom is the ‘peptides’ which have shown diverse array of biological activities, promising site specificity and are also involved in the regulation of biological mechanisms. These peptides have especially gained more attention in the development of cardiovascular and other immune disorders due to the structural and functional specificity. This review is the compilation of the recent developments of therapeutic applications of scorpion peptides including the latest inventions (till 2020). In most of the cases, primary sequence of the peptides as well as the mechanism of action have been given and hence finds suitable in search of lead molecules for further development. Thus, the relevant findings presented here would serve as a valuable source either for improving the pharmacological profile or for new drugs development. |
| first_indexed | 2024-04-13T05:26:19Z |
| format | Article |
| id | doaj.art-0d61939db8fe41a5a4dfb6dc57af4372 |
| institution | Directory Open Access Journal |
| issn | 2772-4174 |
| language | English |
| last_indexed | 2024-04-13T05:26:19Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Medicinal Chemistry Reports |
| spelling | doaj.art-0d61939db8fe41a5a4dfb6dc57af43722022-12-22T03:00:35ZengElsevierEuropean Journal of Medicinal Chemistry Reports2772-41742022-12-016100068Structure, function and mechanistic aspects of scorpion venom peptides - A boon for the development of novel therapeuticsR. Suhas0Postgraduate Department of Chemistry, JSS College of Arts, Commerce and Science (A Recognized Research Centre of University of Mysore), Ooty Road, Mysuru, 25, Karnataka, IndiaVenom of scorpions is very expensive and lethal, yet with innumerable and exciting potential as a source for the development of biotherapeutics. One of the chief components of scorpion venom is the ‘peptides’ which have shown diverse array of biological activities, promising site specificity and are also involved in the regulation of biological mechanisms. These peptides have especially gained more attention in the development of cardiovascular and other immune disorders due to the structural and functional specificity. This review is the compilation of the recent developments of therapeutic applications of scorpion peptides including the latest inventions (till 2020). In most of the cases, primary sequence of the peptides as well as the mechanism of action have been given and hence finds suitable in search of lead molecules for further development. Thus, the relevant findings presented here would serve as a valuable source either for improving the pharmacological profile or for new drugs development.http://www.sciencedirect.com/science/article/pii/S2772417422000401Scorpion venomPeptidesTherapeuticsMedicinal chemistry |
| spellingShingle | R. Suhas Structure, function and mechanistic aspects of scorpion venom peptides - A boon for the development of novel therapeutics European Journal of Medicinal Chemistry Reports Scorpion venom Peptides Therapeutics Medicinal chemistry |
| title | Structure, function and mechanistic aspects of scorpion venom peptides - A boon for the development of novel therapeutics |
| title_full | Structure, function and mechanistic aspects of scorpion venom peptides - A boon for the development of novel therapeutics |
| title_fullStr | Structure, function and mechanistic aspects of scorpion venom peptides - A boon for the development of novel therapeutics |
| title_full_unstemmed | Structure, function and mechanistic aspects of scorpion venom peptides - A boon for the development of novel therapeutics |
| title_short | Structure, function and mechanistic aspects of scorpion venom peptides - A boon for the development of novel therapeutics |
| title_sort | structure function and mechanistic aspects of scorpion venom peptides a boon for the development of novel therapeutics |
| topic | Scorpion venom Peptides Therapeutics Medicinal chemistry |
| url | http://www.sciencedirect.com/science/article/pii/S2772417422000401 |
| work_keys_str_mv | AT rsuhas structurefunctionandmechanisticaspectsofscorpionvenompeptidesaboonforthedevelopmentofnoveltherapeutics |