miRNAs and Substances Abuse: Clinical and Forensic Pathological Implications: A Systematic Review
Substance addiction is a chronic and relapsing brain disorder characterized by compulsive seeking and continued substance use, despite adverse consequences. The high prevalence and social burden of addiction are indisputable; however, the available intervention is insufficient. The modulation of gen...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/23/17122 |
| _version_ | 1797399950794948608 |
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| author | Carla Occhipinti Raffaele La Russa Naomi Iacoponi Julia Lazzari Andrea Costantino Nicola Di Fazio Fabio Del Duca Aniello Maiese Vittorio Fineschi |
| author_facet | Carla Occhipinti Raffaele La Russa Naomi Iacoponi Julia Lazzari Andrea Costantino Nicola Di Fazio Fabio Del Duca Aniello Maiese Vittorio Fineschi |
| author_sort | Carla Occhipinti |
| collection | DOAJ |
| description | Substance addiction is a chronic and relapsing brain disorder characterized by compulsive seeking and continued substance use, despite adverse consequences. The high prevalence and social burden of addiction are indisputable; however, the available intervention is insufficient. The modulation of gene expression and aberrant adaptation of neural networks are attributed to the changes in brain functions under repeated exposure to addictive substances. Considerable studies have demonstrated that miRNAs are strong modulators of post-transcriptional gene expression in substance addiction. The emerging role of microRNA (miRNA) provides new insights into many biological and pathological processes in the central nervous system: their variable expression in different regions of the brain and tissues may play a key role in regulating the pathophysiological events of addiction. This work provides an overview of the current literature on miRNAs involved in addiction, evaluating their impaired expression and regulatory role in neuroadaptation and synaptic plasticity. Clinical implications of such modulatory capacities will be estimated. Specifically, it will evaluate the potential diagnostic role of miRNAs in the various stages of drug and substance addiction. Future perspectives about miRNAs as potential novel therapeutic targets for substance addiction and abuse will also be provided. |
| first_indexed | 2024-03-09T01:48:33Z |
| format | Article |
| id | doaj.art-0d6691eb701c47d89595862bd77d9b88 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T01:48:33Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0d6691eb701c47d89595862bd77d9b882023-12-08T15:18:30ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-12-0124231712210.3390/ijms242317122miRNAs and Substances Abuse: Clinical and Forensic Pathological Implications: A Systematic ReviewCarla Occhipinti0Raffaele La Russa1Naomi Iacoponi2Julia Lazzari3Andrea Costantino4Nicola Di Fazio5Fabio Del Duca6Aniello Maiese7Vittorio Fineschi8Department of Surgical Pathology, Medical, Molecular and Critical Area, Institute of Legal Medicine, University of Pisa, 56126 Pisa, ItalyDepartment of Clinical Medicine, Public Health, Life Sciences, and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Surgical Pathology, Medical, Molecular and Critical Area, Institute of Legal Medicine, University of Pisa, 56126 Pisa, ItalyDepartment of Surgical Pathology, Medical, Molecular and Critical Area, Institute of Legal Medicine, University of Pisa, 56126 Pisa, ItalyDepartment of Surgical Pathology, Medical, Molecular and Critical Area, Institute of Legal Medicine, University of Pisa, 56126 Pisa, ItalyDepartment of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Viale Regina Elena 336, 00161 Rome, ItalyDepartment of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Viale Regina Elena 336, 00161 Rome, ItalyDepartment of Surgical Pathology, Medical, Molecular and Critical Area, Institute of Legal Medicine, University of Pisa, 56126 Pisa, ItalyDepartment of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Viale Regina Elena 336, 00161 Rome, ItalySubstance addiction is a chronic and relapsing brain disorder characterized by compulsive seeking and continued substance use, despite adverse consequences. The high prevalence and social burden of addiction are indisputable; however, the available intervention is insufficient. The modulation of gene expression and aberrant adaptation of neural networks are attributed to the changes in brain functions under repeated exposure to addictive substances. Considerable studies have demonstrated that miRNAs are strong modulators of post-transcriptional gene expression in substance addiction. The emerging role of microRNA (miRNA) provides new insights into many biological and pathological processes in the central nervous system: their variable expression in different regions of the brain and tissues may play a key role in regulating the pathophysiological events of addiction. This work provides an overview of the current literature on miRNAs involved in addiction, evaluating their impaired expression and regulatory role in neuroadaptation and synaptic plasticity. Clinical implications of such modulatory capacities will be estimated. Specifically, it will evaluate the potential diagnostic role of miRNAs in the various stages of drug and substance addiction. Future perspectives about miRNAs as potential novel therapeutic targets for substance addiction and abuse will also be provided.https://www.mdpi.com/1422-0067/24/23/17122substance abuseaddictionalcohol addictioncocaine addictionopioids addictionmethamphetamine addiction |
| spellingShingle | Carla Occhipinti Raffaele La Russa Naomi Iacoponi Julia Lazzari Andrea Costantino Nicola Di Fazio Fabio Del Duca Aniello Maiese Vittorio Fineschi miRNAs and Substances Abuse: Clinical and Forensic Pathological Implications: A Systematic Review International Journal of Molecular Sciences substance abuse addiction alcohol addiction cocaine addiction opioids addiction methamphetamine addiction |
| title | miRNAs and Substances Abuse: Clinical and Forensic Pathological Implications: A Systematic Review |
| title_full | miRNAs and Substances Abuse: Clinical and Forensic Pathological Implications: A Systematic Review |
| title_fullStr | miRNAs and Substances Abuse: Clinical and Forensic Pathological Implications: A Systematic Review |
| title_full_unstemmed | miRNAs and Substances Abuse: Clinical and Forensic Pathological Implications: A Systematic Review |
| title_short | miRNAs and Substances Abuse: Clinical and Forensic Pathological Implications: A Systematic Review |
| title_sort | mirnas and substances abuse clinical and forensic pathological implications a systematic review |
| topic | substance abuse addiction alcohol addiction cocaine addiction opioids addiction methamphetamine addiction |
| url | https://www.mdpi.com/1422-0067/24/23/17122 |
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