Health concerns associated to tropane alkaloids in maize food products in Serbia
Following the implementation of the European regulation limiting the presence of tropane alkaloids in certain foods, a survey was conducted in Serbia on 103 maize products (grits, polenta and semolina) to determine atropine and scopolamine content using liquid chromatography with tandem-mass spectro...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023066124 |
| _version_ | 1797669879618207744 |
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| author | Ljilja Torović Vojislava Bursić Gorica Vuković |
| author_facet | Ljilja Torović Vojislava Bursić Gorica Vuković |
| author_sort | Ljilja Torović |
| collection | DOAJ |
| description | Following the implementation of the European regulation limiting the presence of tropane alkaloids in certain foods, a survey was conducted in Serbia on 103 maize products (grits, polenta and semolina) to determine atropine and scopolamine content using liquid chromatography with tandem-mass spectrometry analysis (LC-MS/MS). The probability of exceeding the Acute Reference Dose (ARfD; 0.016 μg/kg bw/day) of the sum of atropine and scopolamine by consuming these products was tested. Overall, across age categories - children, younger and older adolescents, and adults, the group ARfD was exceeded by 21.4%, 17.5%, 11.7% and 11.7% of the samples, with maximum exposure reaching as much as 19-, 13-, 9- and 9-fold the group ARfD, respectively. Nevertheless, polenta could be the most favorable dietary option (17.9% of positive samples, 7.7% resulting in excessive exposure in children, reaching a maximum of 1.4-fold the group ARfD). According to the reported findings, adverse health effects of tropane alkaloids cannot be ruled out. The Margin of Exposure, founded on a clinically significant acute effects dose established by FAO/WHO, ranged from 1194 to 2381 (mean) and from 28 to 56 (95th percentile) across age categories. These estimates should certainly draw the attention of food authorities and nutritionist, particularly in the case of highly sensitive populations with contraindications and high consumers of corn products, such as coeliac patients. |
| first_indexed | 2024-03-11T20:51:12Z |
| format | Article |
| id | doaj.art-0d66b208c4964c0f84610dc3145ba76d |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-11T20:51:12Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-0d66b208c4964c0f84610dc3145ba76d2023-10-01T05:59:29ZengElsevierHeliyon2405-84402023-09-0199e19404Health concerns associated to tropane alkaloids in maize food products in SerbiaLjilja Torović0Vojislava Bursić1Gorica Vuković2University of Novi Sad, Faculty of Medicine, Department of Pharmacy, Hajduk Veljkova 3, 21000, Novi Sad, Serbia; University of Novi Sad, Faculty of Medicine, Center for Medical and Pharmaceutical Investigations and Quality Control, Hajduk Veljkova 3, 21000, Novi Sad, Serbia; Corresponding author. University of Novi Sad, Faculty of Medicine, Department of Pharmacy, Hajduk Veljkova 3, 21000, Novi Sad, Serbia.University of Novi Sad, Faculty of Agriculture, Trg Dositeja Obradovića 8, 21000, Novi Sad, SerbiaUniversity of Belgrade, Faculty of Agriculture, Nemanjina 6, 11000, Belgrade, SerbiaFollowing the implementation of the European regulation limiting the presence of tropane alkaloids in certain foods, a survey was conducted in Serbia on 103 maize products (grits, polenta and semolina) to determine atropine and scopolamine content using liquid chromatography with tandem-mass spectrometry analysis (LC-MS/MS). The probability of exceeding the Acute Reference Dose (ARfD; 0.016 μg/kg bw/day) of the sum of atropine and scopolamine by consuming these products was tested. Overall, across age categories - children, younger and older adolescents, and adults, the group ARfD was exceeded by 21.4%, 17.5%, 11.7% and 11.7% of the samples, with maximum exposure reaching as much as 19-, 13-, 9- and 9-fold the group ARfD, respectively. Nevertheless, polenta could be the most favorable dietary option (17.9% of positive samples, 7.7% resulting in excessive exposure in children, reaching a maximum of 1.4-fold the group ARfD). According to the reported findings, adverse health effects of tropane alkaloids cannot be ruled out. The Margin of Exposure, founded on a clinically significant acute effects dose established by FAO/WHO, ranged from 1194 to 2381 (mean) and from 28 to 56 (95th percentile) across age categories. These estimates should certainly draw the attention of food authorities and nutritionist, particularly in the case of highly sensitive populations with contraindications and high consumers of corn products, such as coeliac patients.http://www.sciencedirect.com/science/article/pii/S2405844023066124AtropineScopolamineAcute effectRisk assessmentMargin of exposure |
| spellingShingle | Ljilja Torović Vojislava Bursić Gorica Vuković Health concerns associated to tropane alkaloids in maize food products in Serbia Heliyon Atropine Scopolamine Acute effect Risk assessment Margin of exposure |
| title | Health concerns associated to tropane alkaloids in maize food products in Serbia |
| title_full | Health concerns associated to tropane alkaloids in maize food products in Serbia |
| title_fullStr | Health concerns associated to tropane alkaloids in maize food products in Serbia |
| title_full_unstemmed | Health concerns associated to tropane alkaloids in maize food products in Serbia |
| title_short | Health concerns associated to tropane alkaloids in maize food products in Serbia |
| title_sort | health concerns associated to tropane alkaloids in maize food products in serbia |
| topic | Atropine Scopolamine Acute effect Risk assessment Margin of exposure |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023066124 |
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